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Fixed points are fundamental states in any dynamical system. In the case of gene regulatory networks (GRNs) they correspond to stable genes profiles associated to the various cell types. We use Kauffman's approach to model GRNs with random…

Cell Behavior · Quantitative Biology 2012-03-08 Pablo Moisset de Espanés , Axel Osses , Iván Rapaport

We investigate the propagation of perturbations in Boolean networks by evaluating the Derrida plot and modifications of it. We show that even small Random Boolean Networks agree well with the predictions of the annealed approximation, but…

Statistical Mechanics · Physics 2009-05-06 Christoph Fretter , Agnes Szejka , Barbara Drossel

We investigate the dynamical properties of the transcriptional regulation of gene expression in the yeast Saccharomyces Cerevisiae within the framework of a synchronously and deterministically updated Boolean network model. By means of a…

Molecular Networks · Quantitative Biology 2015-05-13 Murat Tugrul , Alkan Kabakcioglu

This paper presents the foundation for a decomposition theory for Boolean networks, a type of discrete dynamical system that has found a wide range of applications in the life sciences, engineering, and physics. Given a Boolean network…

Dynamical Systems · Mathematics 2022-06-10 Claus Kadelka , Reinhard Laubenbacher , David Murrugarra , Alan Veliz-Cuba , Matthew Wheeler

Biological networks of interacting agents exhibit similar topological properties for a wide range of scales, from cellular to ecological levels, suggesting the existence of a common evolutionary origin. A general evolutionary mechanism…

Disordered Systems and Neural Networks · Physics 2010-10-25 Juan I. Perotti , Orlando V. Billoni , Francisco A. Tamarit , Sergio A. Cannas

Boolean networks have been used successfully in modeling biological networks and provide a good framework for theoretical analysis. However, the analysis of large networks is not trivial. In order to simplify the analysis of such networks,…

Molecular Networks · Quantitative Biology 2013-11-29 Alan Veliz-Cuba , Reinhard Laubenbacher , Boris Aguilar

We study a mathematical model of biological neuronal networks composed by any finite number $N \geq 2$ of non necessarily identical cells. The model is a deterministic dynamical system governed by finite-dimensional impulsive differential…

Biological Physics · Physics 2013-11-19 Eleonora Catsigeras

Despite their apparent simplicity, random Boolean networks display a rich variety of dynamical behaviors. Much work has been focused on the properties and abundance of attractors. The topologies of random Boolean networks with one input per…

Disordered Systems and Neural Networks · Physics 2009-11-11 Björn Samuelsson , Carl Troein

We study classes of dynamical systems that can be obtained by constructing recursive networks with monotone Boolean functions. Stack filters in nonlinear signal processing are special cases of such systems. We show an analytical connection…

Disordered Systems and Neural Networks · Physics 2009-07-28 Matti Nykter , Juha Kesseli , Ilya Shmulevich

This paper proposes and investigates a Boolean gossip model as a simplified but non-trivial probabilistic Boolean network. With positive node interactions, in view of standard theories from Markov chains, we prove that the node states…

Social and Information Networks · Computer Science 2017-05-23 Bo Li , Junfeng Wu , Hongsheng Qi , Alexandre Proutiere , Guodong Shi

Robustness of routing policies for networks is a central problem which is gaining increased attention with a growing awareness to safeguard critical infrastructure networks against natural and man-induced disruptions. Routing under limited…

Systems and Control · Computer Science 2012-05-02 Giacomo Como , Ketan Savla , Daron Acemoglu , Munther A. Dahleh , Emilio Frazzoli

Living organisms must respond to environmental changes. Generally, accurate and rapid responses are provided by simple, unidirectional networks that connect inputs with outputs. Besides accuracy and speed, biological responses should also…

Molecular Networks · Quantitative Biology 2021-09-01 Masayo Inoue , Kunihiko Kaneko

The response to a knockout of a node is a characteristic feature of a networked dynamical system. Knockout resilience in the dynamics of the remaining nodes is a sign of robustness. Here we study the effect of knockouts for binary state…

Molecular Networks · Quantitative Biology 2013-05-29 Gunnar Boldhaus , Nils Bertschinger , Johannes Rauh , Eckehard Olbrich , Konstantin Klemm

How do networks of relationships evolve over time? We analyse a dataset tracking the social interactions of 900 individuals over four years. Despite continuous shifts in individual relationships, the macroscopic structural properties of the…

Physics and Society · Physics 2025-06-04 Miguel A. González-Casado , Andreia Sofia Teixeira , Angel Sánchez

We present a renormalization-grouplike method performed in the state space for detecting the dynamical behaviors of large scale-free Boolean networks, especially for the chaotic regime as well as the edge of chaos. Numerical simulations…

Disordered Systems and Neural Networks · Physics 2007-05-23 Wen-Xu Wang , Gang Yan , Jie Ren , Bing-Hong Wang

Random Boolean networks (RBNs) have been a popular model of genetic regulatory networks for more than four decades. However, most RBN studies have been made with random topologies, while real regulatory networks have been found to be…

Cellular Automata and Lattice Gases · Physics 2015-03-17 Rodrigo Poblanno-Balp , Carlos Gershenson

We study the evolution of networks when the creation and decay of links are based on the position of nodes in the network measured by their centrality. We show that the same network dynamics arises under various centrality measures, and…

Physics and Society · Physics 2013-05-29 Michael D. Koenig , Claudio J. Tessone

Networks of interacting nodes connected by edges arise in almost every branch of scientific enquiry. The connectivity structure of the network can force the existence of invariant subspaces, which would not arise in generic dynamical…

Dynamical Systems · Mathematics 2022-02-23 Claire M. Postlethwaite , Rob Sturman

Boolean networks serve as discrete models of regulation and signaling in biological cells. Identifying the key controllers of such processes is important for understanding the dynamical systems and planning further analysis. Here we…

Molecular Networks · Quantitative Biology 2012-09-14 Fakhteh Ghanbarnejad , Konstantin Klemm

Cellular behavior is governed by gene regulatory processes that are intrinsically dynamic and nonlinear, and are subject to non-negligible amounts of random fluctuations. Such conditions are ubiquitous in physical systems, where they have…

Molecular Networks · Quantitative Biology 2011-09-21 Jordi Garcia-Ojalvo