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The stochastic Eigen model proposed by Feng et al. (Journal of theoretical biology, 246 (2007) 28) showed that error threshold is no longer a phase transition point but a crossover region whose width depends on the strength of the random…

Populations and Evolution · Quantitative Biology 2015-06-02 Duo-Fang Li , Tian-Guang Cao , Jin-Peng Geng , Jian-Zhong Gu , Hai-Long An , Yong Zhan

In evolution theory the concept of a fitness landscape has played an important role, evolution itself being portrayed as a hill-climbing process on a rugged landscape. In this article it is shown that in general, in the presence of other…

Adaptation and Self-Organizing Systems · Physics 2016-11-17 C. R. Stephens

A population genetics formulation of Eigen's molecular quasispecies model is proposed and several simple replication landscapes are investigated analytically. Our results show a remarcable similarity to those obtained with the original…

Condensed Matter · Physics 2009-10-28 Domingos Alves , Jose Fernando Fontanari

In any ecosystem, the conditions of the environment and the characteristics of the species that inhabit it are entangled, co-evolving in space and time. We introduce a model that couples active agents with a dynamic environment, interpreted…

Populations and Evolution · Quantitative Biology 2025-12-10 G. Briozzo , G. J. Sibona , F. Peruani

Phenotypic evolution implies sequential fixations of new genomic sequences. The speed at which these mutations fixate depends, in part, on the relative fitness (selection coefficient) of the mutant vs. the ancestor. Using a simple…

Populations and Evolution · Quantitative Biology 2014-02-04 Sorin Tanase-Nicola , Ilya Nemenman

We consider a population of genotype sequences evolving on a rugged fitness landscape with many local fitness peaks. The population walks uphill until it encounters a local fitness maximum. We find that the statistical properties of the…

Populations and Evolution · Quantitative Biology 2015-05-30 Kavita Jain

When biological populations expand into new territory, the evolutionary outcomes can be strongly influenced by genetic drift, the random fluctuations in allele frequencies. Meanwhile, spatial variability in the environment can also…

Populations and Evolution · Quantitative Biology 2024-06-27 Jimmy Gonzalez Nuñez , Jayson Paulose , Wolfram Möbius , Daniel A. Beller

Evolution by Natural Selection is a process by which progeny inherit some properties from their progenitors with small variation. These properties are subject to Natural Selection and are called adaptive traits and carriers of the latter…

Analysis of PDEs · Mathematics 2024-01-29 Gonzalo Galiano , Yosef Cohen

We consider the quasispecies description of a population evolving in both the "master sequence" landscape (where a single sequence is evolutionarily preferred over all others) and the REM landscape (where the fitness of different sequences…

Disordered Systems and Neural Networks · Physics 2009-10-28 Silvio Franz , Luca Peliti

Eigen's quasi-species model describes viruses as ensembles of different mutants of a high fitness "master" genotype. Mutants are assumed to have lower fitness than the master type, yet they coexist with it forming the quasi-species. When…

Populations and Evolution · Quantitative Biology 2012-02-02 Jose A. Cuesta

We study the adaptation dynamics of an initially maladapted asexual population with genotypes represented by binary sequences of length $L$. The population evolves in a maximally rugged fitness landscape with a large number of local optima.…

Populations and Evolution · Quantitative Biology 2007-05-23 Kavita Jain , Joachim Krug

We review the major progress in the rigorous analysis of the classical quasispecies model that usually comes in two related but different forms: the Eigen model and the Crow--Kimura model. The model itself was formulated almost 50 years…

Populations and Evolution · Quantitative Biology 2017-12-12 Alexander S. Bratus , Artem S. Novozhilov , Yuri S. Semenov

World record setting has long attracted public interest and scientific investigation. Extremal records summarize the limits of the space explored by a process, and the historical progression of a record sheds light on the underlying…

Quasispecies theory provides the conceptual and theoretical bases for describing the dynamics of biological information of replicators subject to large mutation rates. This theory, initially conceived within the framework of prebiotic…

Populations and Evolution · Quantitative Biology 2025-06-26 Edward A. Turner , Francisco Crespo , Josep Sardanyés , Nolbert Morales

For taxonomic levels higher than species, the abundance distributions of number of subtaxa per taxon tend to approximate power laws, but often show strong deviationns from such a law. Previously, these deviations were attributed to…

Biological Physics · Physics 2009-11-06 Johan Chu , Chris Adami

We consider how transfer of genetic information between individuals influences the phase diagram and mean fitness of both the Eigen and the parallel, or Crow-Kimura, models of evolution. In the absence of genetic transfer, these physical…

Populations and Evolution · Quantitative Biology 2009-11-13 Jeong-Man Park , Michael W. Deem

How fast does a population evolve from one fitness peak to another? We study the dynamics of evolving, asexually reproducing populations in which a certain number of mutations jointly confer a fitness advantage. We consider the time until a…

Populations and Evolution · Quantitative Biology 2010-03-31 Chaitanya S. Gokhale , Yoh Iwasa , Martin A. Nowak , Arne Traulsen

We study a class of evolution models, where the breeding process involves an arbitrary exchangeable process, allowing for mutations to appear. The population size $n$ is fixed, hence after breeding, selection is applied. Individuals are…

Probability · Mathematics 2022-05-03 Daniela Bertacchi , Juri Lember , Fabio Zucca

In many models of genotypic evolution, the vector of genotype populations satisfies a system of linear ordinary differential equations. This system of equations models a competition between differential replication rates (fitness) and…

Populations and Evolution · Quantitative Biology 2009-11-13 Charles L. Epstein

We introduce a generalization of the parallel, or Crow-Kimura, and Eigen models of molecular evolution to represent the exchange of genetic information between individuals in a population. We study the effect of different schemes of genetic…

Populations and Evolution · Quantitative Biology 2009-11-13 Enrique Munoz , Jeong-Man Park , Michael W. Deem