Related papers: Ultimate limit to human longevity
Motivated by the wide range of known self-replicating systems, some far from genetics, we study a system composed by individuals having an internal dynamics with many possible states that are partially stable, with varying mutation rates.…
At the physiological level, aging is neither rigid nor unchangeable. Instead, the molecular and mechanisms driving aging are sufficiently plastic that a variety of diverse interventions--dietary, pharmaceutical, and genetic--have been…
Predicting an individual's aging trajectory is a central challenge in preventative medicine and bioinformatics. While machine learning models can predict chronological age from biomarkers, they often fail to capture the dynamic,…
Large whole-genome sequencing projects have provided access to much of the rare variation in human populations, which is highly informative about population structure and recent demography. Here, we show how the age of rare variants can be…
In this work, we explore constraints on the emergence and longevity of technologically intelligent civilizations in our Galaxy, considering the Fermi paradox. We argue that under optimistic assumptions about the probability of life and…
Following our previous works on the health state of a population and the related health state function we proceed in developing a method to estimate the Healthy Life Expectancy in connection to the relative impact of the Mortality Area in…
Correlations between high life expectancy and low lifespan inequality are frequently observed. A recent article seeks to explain this phenomenon by proposing that a mortality improvement maps to life expectancy and relative lifespan…
Online genealogy datasets contain extensive information about millions of people and their past and present family connections. This vast amount of data can assist in identifying various patterns in human population. In this study, we…
We show that a simple nonlinear differential equation (originally studied in the physics of disordered systems) is able to mathematically describe the global population growth over the past 12000 years. Different regimes of population…
We analyze mathematical models of the global human population growth and compare them to actual dynamics of the world population and of the world surplus product. We consider a possibility that the so-called world's demographic transition…
In a general way at all ages and for almost all diseases, male death rates are higher than female death rates. Here we report a case in which the opposite holds, namely for tuberculosis (TB) mortality between the ages of 5 and 25, female…
The recent interest in human dynamics has led researchers to investigate the stochastic processes that explain human behaviour in various contexts. Here we propose a generative model to capture the dynamics of survival analysis,…
We estimate cumulative CO2 emissions during the period 2000 to 2050 from developed and developing countries based on the empirical relationship between CO2 per capita emissions (due to fossil fuel combustion and cement production) and…
Twenty years ago, after analysing palaeontological data, Raup and Sepkoski suggested that mass extinctions on Earth appear cyclically in time with a period of approximately 26 million years (My). To explain the 26My period, a number of…
Theoretical analysis proves that human survivability is dominated by an unusual physical, rather than biological, mechanism, which yields an exact law. The law agrees with all experimental data, but, contrary to existing theories, it is the…
In this paper we explore the very important case of finding a health measure in the lines of the survival curve but independent of the standard deviation parameter. This is done by estimating the health state curve and calculating the total…
Given a sufficiently large universe, numerous civilizations almost surely exist. Some of these civilizations will be short-lived and die out relatively early in their development, i.e., before having the chance to spread to other planets.…
Suitable assumptions for the Gompertz mortality law take into account the break in the time development observed recently by Wilmoth et al. They show how a drastic reduction in the birth rate and improved living conditions lead to a drastic…
We solve a lifecycle model in which the consumer's chronological age does not move in lockstep with calendar time. Instead, biological age increases at a stochastic non-linear rate in time like a broken clock that might occasionally move…
The analytic derivation of a more general model of survival-mortality and the estimation of a parameter bx related to the Healthy Life Years Lost (HLYL) is followed with the formulation of a computer program providing results similar to…