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We study the electronic properties of DNA by way of a tight-binding model applied to four particular DNA sequences. The charge transfer properties are presented in terms of localisation lengths, crudely speaking the length over which…

Genomics · Quantitative Biology 2007-05-23 Daphne Klotsa , Rudolf A. Roemer , Matthew S. Turner

The precision of biochemical signaling is limited by randomness in the diffusive arrival of molecules at their targets. For proteins binding to the specific sites on the DNA and regulating transcription, the ability of the proteins to…

Molecular Networks · Quantitative Biology 2013-08-01 Gasper Tkacik , William Bialek

Synaptic connections in neuronal circuits are modulated by pre- and post-synaptic spiking activity. Heuristic models of this process of synaptic plasticity can provide excellent fits to results from in-vitro experiments in which pre- and…

Neurons and Cognition · Quantitative Biology 2022-07-14 Federico Devalle , Alex Roxin

The percentage and sequence of AT and GC base pairs and charges on the DNA backbone contribute significantly to the stiffness of DNA. This elastic property of DNA also changes with small interacting ligands. The single-molecule force…

Soft Condensed Matter · Physics 2017-02-02 Anurag Singh , Amar Nath Gupta

We investigate the electron (hole) transport through short double-stranded DNA wires in which the electrons are strongly coupled to the specific vibrational modes (vibrons) of the DNA. We analyze the problem starting from a tight-binding…

Mesoscale and Nanoscale Physics · Physics 2015-06-25 Benjamin B. Schmidt , Matthias H. Hettler , Gerd Schön

The spatial organization of DNA involves DNA loop extrusion and the formation of protein-DNA condensates. While the significance of each process is increasingly recognized, their interplay remains unexplored. Using molecular dynamics…

Biological Physics · Physics 2025-01-31 Ryota Takaki , Yahor Savich , Jan Brugués , Frank Jülicher

Collective dynamics result from interactions among noisy dynamical components. Examples include heartbeats, circadian rhythms, and various pattern formations. Because of noise in each component, collective dynamics inevitably involve…

Biological Physics · Physics 2010-09-09 Naoki Masuda , Yoji Kawamura , Hiroshi Kori

We study the diffusion of a tracer particle driven out-of-equilibrium by an external force and traveling in a dense environment of arbitrary density. The system evolves on a discrete lattice and its stochastic dynamics is described by a…

Statistical Mechanics · Physics 2018-05-23 Pierre Illien , Olivier Bénichou , Gleb Oshanin , Alessandro Sarracino , Raphaël Voituriez

Transposable elements, or transposons, are DNA sequences that can jump from site to site in the genome during the life cycle of a cell, usually encoding the very enzymes which perform their excision. However, some transposons are parasitic,…

Populations and Evolution · Quantitative Biology 2016-11-16 Chi Xue , Nigel Goldenfeld

We investigate diffusion of excitation in one- and two-dimensional lattices with random on-site energies and deterministic long-range couplings (hopping) inversely proportional to the distance. Three regimes of diffusion are observed in…

Disordered Systems and Neural Networks · Physics 2020-11-18 Karol Kawa , Paweł Machnikowski

This paper considers the propagation of excitons in linear chains of QDs with a side defect, located on a dielectric substrate. This configuration is suitable for spatially selective excitation of the system by pulsed optical radiation…

Mesoscale and Nanoscale Physics · Physics 2026-02-17 Aleksey Vlasov , Pavel Golovinski

By resorting to a model inspired to the standard Davydov and Holstein-Fr\"ohlich models, in the present paper we study the motion of an electron along a chain of heavy particles modelling a sequence of nucleotides proper to a DNA fragment.…

Biological Physics · Physics 2021-08-17 Elham Faraji , Roberto Franzosi , Stefano Mancini , Marco Pettini

We calculate the power spectrum of density fluctuations in the statistical non-equilibrium field theory for classical, microscopic degrees of freedom to first order in the interaction potential. We specialise our result to cosmology by…

Cosmology and Nongalactic Astrophysics · Physics 2014-11-07 Matthias Bartelmann , Felix Fabis , Daniel Berg , Elena Kozlikin , Robert Lilow , Celia Viermann

The telegraph model is the standard model of stochastic gene expression, which can be solved exactly to obtain the distribution of mature RNA numbers per cell. A modification of this model also leads to an analytical distribution of the…

Subcellular Processes · Quantitative Biology 2023-08-17 Juraj Szavits-Nossan , Ramon Grima

The effect of sequence heterogeneity on polynucleotide translocation across a pore and on simple models of molecular motors such as helicases, DNA polymerase/exonuclease and RNA polymerase is studied in detail. Pore translocation of RNA or…

Statistical Mechanics · Physics 2009-11-10 Yariv Kafri , David K. Lubensky , David R. Nelson

Droplet solitons are a strongly nonlinear, inherently dynamic structure in the magnetization of ferromagnets, balancing dispersion (exchange energy) with focusing nonlinearity (strong perpendicular anisotropy). Large droplet solitons have…

Pattern Formation and Solitons · Physics 2015-06-29 L. D. Bookman , M. A. Hoefer

We study the non-linear behavior of the baryon acoustic oscillation in the power spectrum and the correlation function by decomposing the dark matter perturbations into the short- and long-wavelength modes. The evolution of the dark matter…

Cosmology and Nongalactic Astrophysics · Physics 2014-02-27 Naonori S. Sugiyama , David N. Spergel

The development of new techniques to quantitatively measure gene expression in cells has shed light on a number of systems that display oscillations in protein concentration. Here we review the different mechanisms which can produce…

Molecular Networks · Quantitative Biology 2009-11-13 G. Tiana , S. Krishna , S. Pigolotti , M. H. Jensen , K. Sneppen

Recurrent networks of non-linear units display a variety of dynamical regimes depending on the structure of their synaptic connectivity. A particularly remarkable phenomenon is the appearance of strongly fluctuating, chaotic activity in…

Neurons and Cognition · Quantitative Biology 2017-05-10 Francesca Mastrogiuseppe , Srdjan Ostojic

We study statistical properties of DNA chains of thirteen microbial complete genomes. We find that the power spectrum of several of the sequences studied flattens off in the low frequency limit. This implies that the correlation length in…

Statistical Mechanics · Physics 2009-10-31 Maria de Sousa Vieira