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Recordings from neurons in the insects' olfactory primary processing center, the antennal lobe (AL), reveal that the AL is able to process the input from chemical receptors into distinct neural activity patterns, called olfactory neural…

Neurons and Cognition · Quantitative Biology 2014-08-27 Eli Shlizerman , Jeffrey A. Riffell , J. Nathan Kutz

This article provides a background and descriptive analysis of insect memory and the coding of olfactory sensation in Drosophila, presenting graphs and summary statistics from a large dataset of neurons and synapses that was recently made…

Neurons and Cognition · Quantitative Biology 2022-09-07 Chris Rohlfs

Advances in neural sensing technology are making it possible to observe the olfactory process in great detail. In this paper, we conceptualize smell from a Data Science and AI perspective, that relates the properties of odorants to how they…

Neurons and Cognition · Quantitative Biology 2024-04-09 Vivek Agarwal , Joshua Harvey , Dmitry Rinberg , Vasant Dhar

Understanding how molecular structure gives rise to odor perception remains a long-standing challenge, with ongoing debate over whether olfaction is primarily governed by molecular shape, vibrational properties, or their interplay at the…

Materials Science · Physics 2026-04-14 P. Zanineli , E. V. C. Lopes , G. R. Schleder , L. N. Lemos , F. Crasto de Lima , A. Fazzio

The olfactory system employs responses of an ensemble of odorant receptors (ORs) to sense molecules and to generate olfactory percepts. Here we hypothesized that ORs can be viewed as 3D spatial filters that extract molecular features…

Machine Learning · Computer Science 2024-12-13 Sergey Shuvaev , Khue Tran , Khristina Samoilova , Cyrille Mascart , Alexei Koulakov

Mitral cells, the principal neurons in the olfactory bulb, respond to odorants by firing bursts of action potentials called sharp events. A given cell produces a sharp event at a fixed phase during the sniff cycle in response to a given…

Neurons and Cognition · Quantitative Biology 2014-07-02 Honi Sanders , Brian Kolterman , Roman Shusterman , Dmitry Rinberg , Alexei A. Koulakov , John Lisman

Olfactory search in turbulent environments is a sensorimotor challenge solved with remarkable efficiency by many animals, yet replicating this ability in artificial systems remains difficult because detections are intermittent and wind…

Olfactory receptor usage is highly heterogeneous, with some receptor types being orders of magnitude more abundant than others. We propose an explanation for this striking fact: the receptor distribution is tuned to maximally represent…

Neurons and Cognition · Quantitative Biology 2019-01-23 Tiberiu Tesileanu , Simona Cocco , Remi Monasson , Vijay Balasubramanian

Animal behavior and neural recordings show that the brain is able to measure both the intensity of an odor and the timing of odor encounters. However, whether intensity or timing of odor detections is more informative for olfactory-driven…

Quantitative Methods · Quantitative Biology 2021-06-17 Nicola Rigolli , Nicodemo Magnoli , Lorenzo Rosasco , Agnese Seminara

Early olfactory pathway responses to the presentation of an odor exhibit remarkably similar dynamical behavior across phyla from insects to mammals, and frequently involve transitions among quiescence, collective network oscillations, and…

Neurons and Cognition · Quantitative Biology 2020-09-29 Pamela B Pyzza , Katherine A Newhall , Douglas Zhou , Gregor Kovacic , David Cai

We present a novel machine learning architecture for classification suggested by experiments on olfactory systems. The network separates input stimuli, represented as spatially distinct currents, via winnerless competition---a process based…

Biological Physics · Physics 2020-06-18 Jason A. Platt , Anna Miller , Lawson Fuller , Henry D. I. Abarbanel

Animals smelling in the real world use a small number of receptors to sense a vast number of natural molecular mixtures, and proceed to learn arbitrary associations between odors and valences. Here, we propose a new interpretation of how…

Neurons and Cognition · Quantitative Biology 2017-07-10 Kamesh Krishnamurthy , Ann M Hermundstad , Thierry Mora , Aleksandra M Walczak , Vijay Balasubramanian

The olfactory system removes correlations in natural odors using a network of inhibitory neurons in the olfactory bulb. It has been proposed that this network integrates the response from all olfactory receptors and inhibits them equally.…

Neurons and Cognition · Quantitative Biology 2022-01-31 David Zwicker

Advancing our knowledge of how the brain processes information remains a key challenge in neuroscience. This thesis combines three different approaches to the study of the dynamics of neural networks and their encoding representations: a…

Neurons and Cognition · Quantitative Biology 2024-02-21 Guillermo B. Morales

We present a generalized theoretical framework for olfactory representation and plasticity, using the theory of smooth manifolds and sheaves to depict categorical odor learning via distributed neural computation. Beginning with the space of…

Neurons and Cognition · Quantitative Biology 2023-10-13 Jack A. Cook , Thomas A. Cleland

In the olfactory system, odor percepts retain their identity despite substantial variations in concentration, timing, and background. We propose a novel strategy for encoding intensity-invariant stimuli identity that is based on…

Neurons and Cognition · Quantitative Biology 2016-09-09 Daniel Kepple , Hamza Giaffar , Dmitry Rinberg , Alexei Koulakov

Local computation in microcircuits is an essential feature of distributed information processing in vertebrate and invertebrate brains. The insect antennal lobe represents a spatially confined local network that processes high-dimensional…

Neurons and Cognition · Quantitative Biology 2012-12-27 Anneke Meyer , Giovanni Galizia , Martin P. Nawrot

This study investigates the dynamics of non-spatial specializations in hippocampal place cells during exposure to novel environments. Hippocampal place cells, known for their role in spatial mapping, exhibit multi-modal responses to sensory…

The prediction of odor characters is still impossible based on the odorant molecular structure. We designed a CNN-based regressor for computed parameters in molecular vibrations (CNN\_vib), in order to investigate the ability to predict…

Chemical Physics · Physics 2025-09-23 Yuki Harada , Shuichi Maeda , Junwei Shen , Taku Misonou , Hirokazu Hori , Shinichiro Nakamura

Competitive interactions represent one of the driving forces behind evolution and natural selection in biological and sociological systems. For example, animals in an ecosystem may vie for food or mates; in a market economy, firms may…

Physics and Society · Physics 2013-07-03 Jacobo Aguirre , David Papo , Javier M. Buldú
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