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In this review we discuss different mathematical models of gene regulatory networks as relevant to the onset and development of cancer. After discussion of alternative modelling approaches, we use a paradigmatic two-gene network to focus on…

Molecular Networks · Quantitative Biology 2015-10-30 K. Parmar , K. B. Blyuss , Y. N. Kyrychko , S. J. Hogan

The problem of synchronization in heterogeneous networks of linear systems with nonlinear delayed diffusive coupling is considered. The network is presented in new coordinates mean-field dynamics and synchronization errors. Thus the problem…

Adaptation and Self-Organizing Systems · Physics 2022-05-11 Sergei A. Plotnikov

We study the synchronization of chaotic units connected through time-delayed fluctuating interactions. We focus on small-world networks of Bernoulli and Logistic units with a fixed chiral backbone. Comparing the synchronization properties…

Robustness to mutations and noise has been shown to evolve through stabilizing selection for optimal phenotypes in model gene regulatory networks. The ability to evolve robust mutants is known to depend on the network architecture. How do…

Molecular Networks · Quantitative Biology 2008-07-07 Volkan Sevim , Per Arne Rikvold

This paper deals with the global stability of time-delayed dynamical networks. We show that for a time-delayed dynamical network with non-distributed delays the network and the corresponding non-delayed network are both either globally…

Dynamical Systems · Mathematics 2015-06-05 Lenonid Bunimovich , Benjamin Webb

In this manuscript, we study the problem of robust synchronization in networks of diffusively time-delayed coupled nonlinear systems. In particular, we prove that, under some mild conditions on the input-output dynamics of the systems and…

Systems and Control · Computer Science 2017-11-01 Carlos Murguia , Henk Nijmeijer , Justin Ruths

Living organisms must respond to environmental changes. Generally, accurate and rapid responses are provided by simple, unidirectional networks that connect inputs with outputs. Besides accuracy and speed, biological responses should also…

Molecular Networks · Quantitative Biology 2021-09-01 Masayo Inoue , Kunihiko Kaneko

We study delay-induced transitions in consensus dynamics on signed networks with a ring topology. The proposed model is formulated as a system of delay differential equations incorporating both cooperative and antagonistic interactions, as…

Dynamical Systems · Mathematics 2026-04-20 Hui Wu

Rhythmic activities that alternate between coherent and incoherent phases are ubiquitous in chemical, ecological, climate, or neural systems. Despite their importance, general mechanisms for their emergence are little understood. In order…

Adaptation and Self-Organizing Systems · Physics 2022-06-01 Max Thiele , Rico Berner , Peter A. Tass , Eckehard Schöll , Serhiy Yanchuk

The problem of reliability of the dynamics in biological regulatory networks is studied in the framework of a generalized Boolean network model with continuous timing and noise. Using well-known artificial genetic networks such as the…

Molecular Networks · Quantitative Biology 2008-05-28 Stefan Braunewell , Stefan Bornholdt

We study systems of identical coupled oscillators introducing a distribution of delay times in the coupling. For arbitrary network topologies, we show that the frequency and stability of the fully synchronized states depend only on the mean…

Chaotic Dynamics · Physics 2016-07-04 Lucas Wetzel , Luis G. Morelli , Andrew C. Oates , Frank Julicher , Saul Ares

Phase transitions constitute fundamental mechanisms underlying abrupt or qualitative changes in the collective dynamics of interacting units across a wide range of natural and engineered systems. In dynamical networks, such transitions lead…

Adaptation and Self-Organizing Systems · Physics 2026-04-07 R. Anand , Jan Fialkowski , V. K. Chandrasekar , R. Suresh

We investigate the stability of synchronization in networks of delay-coupled excitable neural oscillators. On the basis of the master stability function formalism, we demonstrate that synchronization is always stable for excitatory coupling…

Disordered Systems and Neural Networks · Physics 2016-08-10 Judith Lehnert , Thomas Dahms , Philipp Hövel , Eckehard Schöll

Coupled map lattices are paradigmatic models of many collective phenomena. However, quite different patterns can emerge depending on the updating scheme. While in early versions, maps were updated synchronously, there has been in recent…

Chaotic Dynamics · Physics 2016-06-15 Juan Carlos González-Avella , Celia Anteneodo

We consider networks of coupled maps where the connections between units involve time delays. We show that, similar to the undelayed case, the synchronization of the network depends on the connection topology, characterized by the spectrum…

Disordered Systems and Neural Networks · Physics 2007-05-23 Fatihcan M. Atay , Jürgen Jost , Andreas Wende

Delays and stochasticity have both served as crucially valuable ingredients in mathematical descriptions of control, physical, and biological systems. In this work, we investigate how explicitly dynamical stochasticity in delays modulates…

Molecular Networks · Quantitative Biology 2023-07-10 Bhargav R. Karamched , Christopher E. Miles

Precise timing of spikes and temporal locking are key elements of neural computation. Here we demonstrate how even strongly heterogeneous, deterministic neural networks with delayed interactions and complex topology can exhibit periodic…

Neurons and Cognition · Quantitative Biology 2009-11-13 Raoul-Martin Memmesheimer , Marc Timme

We present the $\delta$-Synchronizer, which works in non-synchronous dynamic networks under minimal assumptions. Our model allows for arbitrary topological changes without any guarantee of eventual global or partial stabilization and…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-10-30 Rida Bazzi , Cameron Bickley , Anya Chaturvedi , Andréa W. Richa , Peter Vargas

Being fundamentally a non-equilibrium process, synchronization comes with unavoidable energy costs and has to be maintained under the constraint of limited resources. Such resource constraints are often reflected as a finite coupling budget…

Adaptation and Self-Organizing Systems · Physics 2021-06-02 Yuanzhao Zhang , Steven H. Strogatz

In this article, we study algorithms for dynamic networks with asynchronous start, i.e., each node may start running the algorithm in a different round. Inactive nodes transmit only heartbeats, which contain no information but can be…

Distributed, Parallel, and Cluster Computing · Computer Science 2017-06-27 Bernadette Charron-Bost , Shlomo Moran