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Epilepsy is a dynamic and complex neurological disease affecting about 1% of the worldwide population, among which 30% of the patients are drug-resistant. Epilepsy is characterized by recurrent episodes of paroxysmal neural discharges (the…

Neurons and Cognition · Quantitative Biology 2021-01-27 Elif Köksal Ersöz , Julien Modolo , Fabrice Bartolomei , Fabrice Wendling

The dynamics underlying epileptic seizures are well understood. We present a novel analysis of seizure-like events (SLEs) in an \textit{ex vivo} whole hippocampus, as well as a modeling study that sheds light on the underlying network…

Biological Physics · Physics 2007-05-23 Benjamin H. Singer , Miron Derchansky , Peter L. Carlen , Michal Zochowski

We propose a convolutional neural network (CNN) aided factor graphs assisted by mutual information features estimated by a neural network for seizure detection. Specifically, we use neural mutual information estimation to evaluate the…

Signal Processing · Electrical Eng. & Systems 2022-03-14 Bahareh Salafian , Eyal Fishel Ben-Knaan , Nir Shlezinger , Sandrine de Ribaupierre , Nariman Farsad

Epileptic seizure detection from EEG signals remains challenging due to the high dimensionality and nonlinear, potentially stochastic, dynamics of neural activity. In this work, we investigate whether features derived from topological data…

Machine Learning · Computer Science 2026-04-15 Sunia Tanweer , Narayan Puthanmadam Subramaniyam , Firas A. Khasawneh

Topological data analysis (TDA) approaches are becoming increasingly popular for studying the dependence patterns in multivariate time series data. In particular, various dependence patterns in brain networks may be linked to specific tasks…

Methodology · Statistics 2023-12-04 Anass B. El-Yaagoubi , Hernando Ombao

Low-dimensional yet rich dynamics often emerge in the brain. Examples include oscillations and chaotic dynamics during sleep, epilepsy, and voluntary movement. However, a general mechanism for the emergence of low dimensional dynamics…

Neurons and Cognition · Quantitative Biology 2018-08-29 Wilten Nicola , Peter Hellyer , Sue Ann Campbell , Claudia Clopath

Objective: The aim of this study is to develop an efficient and reliable epileptic seizure prediction system using intracranial EEG (iEEG) data, especially for people with drug-resistant epilepsy. The prediction procedure should yield…

Neural and Evolutionary Computing · Computer Science 2019-04-09 Ramy Hussein , Mohamed Osama Ahmed , Rabab Ward , Z. Jane Wang , Levin Kuhlmann , Yi Guo

A brain wide association study (BWAS) based on the logistic regression was first developed and applied to a large population of epilepsy patients (168) and healthy controls (136). It was found that the most significant links associated with…

Medical Physics · Physics 2012-09-26 Wei Cheng , Xuejuan Zhang , Ge Tian , Jianfeng Feng , Zhengge Wang , Zhiqiang Zhang , GuangMing Lu

Predicting future system behaviour from past observed behaviour (time series) is fundamental to science and engineering. In computational neuroscience, the prediction of future epileptic seizures from brain activity measurements, using EEG…

In this paper, we propose a time-series stochastic model based on a scale mixture distribution with Markov transitions to detect epileptic seizures in electroencephalography (EEG). In the proposed model, an EEG signal at each time point is…

Signal Processing · Electrical Eng. & Systems 2021-11-15 Akira Furui , Tomoyuki Akiyama , Toshio Tsuji

Objective: This work presents a new computational framework to assist neurophysiologists in Stereoelectroencephalography (SEEG) analysis, with the goal of improving the definition of the Epileptogenic Zone (EZ) in patients with…

We study the dynamics of $N$-dimensional lattices of nonchaotic Rulkov neurons coupled with a flow of electrical current. We consider both nearest-neighbor and next-nearest-neighbor couplings, homogeneous and heterogeneous neurons, and…

Chaotic Dynamics · Physics 2025-07-14 Brandon B. Le , Dima Watkins

Electroencephalography (EEG) is essential for the diagnosis of epilepsy, but it requires expertise and experience to identify abnormalities. It is thus crucial to develop automated models for the detection of abnormalities in EEGs related…

Signal Processing · Electrical Eng. & Systems 2021-11-23 Taku Shoji , Noboru Yoshida , Toshihisa Tanaka

The identification of abnormal electrographic activity is important in a wide range of neurological disorders, including epilepsy for localising epileptogenic tissue. However, this identification may be challenging during non-seizure…

Recurrent Neural Network models have elucidated the interplay between structure and dynamics in biological neural networks, particularly the emergence of irregular and rhythmic activities in cortex. However, most studies have focused on…

Neurons and Cognition · Quantitative Biology 2025-09-04 Nimrod Sherf , Xaq Pitkow , Krešimir Josić , Kevin E. Bassler

Automated epileptic seizure detection from electroencephalogram (EEG) remains challenging due to significant individual differences in EEG patterns across patients. While existing studies achieve high accuracy with patient-specific…

Signal Processing · Electrical Eng. & Systems 2025-05-22 Rina Tazaki , Tomoyuki Akiyama , Akira Furui

Epilepsy represents the most prevalent neurological disease in the world. One-third of people suffering from mesial temporal lobe epilepsy (MTLE) exhibit drug resistance, urging the need to develop new treatments. A key part in anti-seizure…

Objective: Epilepsy is a chronic neurological disorder characterized by the occurrence of spontaneous seizures, which affects about one percent of the world's population. Most of the current seizure detection approaches strongly rely on…

Signal Processing · Electrical Eng. & Systems 2020-02-04 Xiang Zhang , Lina Yao , Manqing Dong , Zhe Liu , Yu Zhang , Yong Li

Detecting seizure using brain neuroactivations recorded by intracranial electroencephalogram (iEEG) has been widely used for monitoring, diagnosing, and closed-loop therapy of epileptic patients, however, computational efficiency gains are…

Computer Vision and Pattern Recognition · Computer Science 2017-02-01 Nhan Truong , Levin Kuhlmann , Mohammad Reza Bonyadi , Jiawei Yang , Andrew Faulks , Omid Kavehei

Successful epilepsy surgery depends on localising and resecting cerebral abnormalities and networks that generate seizures. Abnormalities, however, may be widely distributed across multiple discontiguous areas. We propose spatially…

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