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While visual and auditory information conveyed by wavelength of light and frequency of sound have been decoded, predicting olfactory information encoded by the combination of odorants remains challenging due to the unknown and potentially…

Machine Learning · Computer Science 2023-05-23 Mengji Zhang , Yusuke Hiki , Akira Funahashi , Tetsuya J. Kobayashi

In this paper, we propose a novel concept for engineered molecular communication (MC) systems inspired by animal olfaction. We focus on a multi-user scenario where several transmitters wish to communicate with a central receiver. We assume…

Information Theory · Computer Science 2022-03-09 Vahid Jamali , Helene M. Loos , Andrea Buettner , Robert Schober , H. Vincent Poor

Fruit flies are established model systems for studying olfactory learning as they will readily learn to associate odors with both electric shock or sugar rewards. The mechanisms of the insect brain apparently responsible for odor learning…

Machine Learning · Computer Science 2025-01-09 Jinyung Hong , Theodore P. Pavlic

The integration of neural representations in the two hemispheres is an important problem in neuroscience. Recent experiments revealed that odor responses in cortical neurons driven by separate stimulation of the two nostrils are highly…

Neurons and Cognition · Quantitative Biology 2024-12-17 Bo Liu , Shanshan Qin , Venkatesh Murthy , Yuhai Tu

Natural odors typically consist of many molecules at different concentrations. It is unclear how the numerous odorant molecules and their possible mixtures are discriminated by relatively few olfactory receptors. Using an…

Biological Physics · Physics 2016-08-26 David Zwicker , Arvind Murugan , Michael P. Brenner

Associating multiple sensory cues with a single experience or object is a fundamental process that improves object recognition and memory performance. However, neural mechanisms that bind sensory features during learning and augment memory…

We analyze the psychophysical responses of human observers to an ensemble of monomolecular odorants. Each odorant is characterized by a set of 146 perceptual descriptors obtained from a database of odor character profiles. Each odorant is…

Neurons and Cognition · Quantitative Biology 2009-07-24 Alexei A. Koulakov , Armen G. Enikolopov , Dmitry Rinberg

Insects identify and evaluate behaviorally relevant odorants in complex natural scenes where odor concentrations and mixture composition can change rapidly. In the honeybee, a combinatorial code of activated and inactivated projection…

Biological Physics · Physics 2011-01-06 Martin Paul Nawrot , Sabine Krofczik , Farzad Farkhooi , Randolf Menzel

Sensory hair cells in auditory and vestibular organs rely on active mechanisms to achieve high sensitivity and frequency selectivity. Recent experimental studies have documented self-sustained oscillations in hair cells of lower vertebrates…

Biological Physics · Physics 2012-09-28 Rami Amro , Alexander B. Neiman

Molecular odor prediction has great potential across diverse fields such as chemistry, pharmaceuticals, and environmental science, enabling the rapid design of new materials and enhancing environmental monitoring. However, current methods…

Machine Learning · Computer Science 2025-02-04 HongXin Xie , JianDe Sun , Yi Shao , Shuai Li , Sujuan Hou , YuLong Sun , Yuxiang Liu

This research introduces a Machine Learning-centric approach to replicate olfactory experiences, validated through experimental quantification of perfume perception. Key contributions encompass a hybrid model connecting perfume molecular…

Most neurons in peripheral sensory pathways initially respond vigorously when a preferred stimulus is presented, but adapt as stimulation continues. It is unclear how this phenomenon affects stimulus representation in the later stages of…

Neurons and Cognition · Quantitative Biology 2012-10-29 Farzad Farkhooi , Anja Froese , Eilif Muller , Randolf Menzel , Martin P. Nawrot

Here we introduce the Olfactory Perception (OP) benchmark, designed to assess the capability of large language models (LLMs) to reason about smell. The benchmark contains 1,010 questions across eight task categories spanning odor…

Computation and Language · Computer Science 2026-04-02 Eftychia Makri , Nikolaos Nakis , Laura Sisson , Gigi Minsky , Leandros Tassiulas , Vahid Satarifard , Nicholas A. Christakis

Predicting odor's pleasantness simplifies the evaluation of odors and has the potential to be applied in perfumes and environmental monitoring industry. Classical algorithms for predicting odor's pleasantness generally use a manual feature…

Machine Learning · Computer Science 2019-03-20 Danli Wu , Yu Cheng , Dehan Luo , Kin-Yeung Wong , Kevin Hung , Zhijing Yang

Odor source localization is a fundamental challenge in molecular communication, environmental monitoring, disaster response, industrial safety, and robotics. In this study, we investigate three major approaches: Bayesian filtering, machine…

Signal Processing · Electrical Eng. & Systems 2025-02-12 Ayse Sila Okcu , Ozgur B. Akan

This study examines the modulatory effect of contextual hedonic olfactory stimuli on the visual processing of neutral faces using event-related potentials (ERPs) and effective connectivity analysis. The aim is to investigate how odors'…

One of the key challenges to predict odor from molecular structure is unarguably our limited understanding of the odor space and the complexity of the underlying structure-odor relationships. Here, we show that the predictive performance of…

Quantitative Methods · Quantitative Biology 2025-08-14 Akshay Sajan , Stijn Sluis , Reza Haydarlou , Sanne Abeln , Pasquale Lisena , Raphael Troncy , Caro Verbeek , Inger Leemans , Halima Mouhib

We introduce the concept of self-tuned criticality as a general mechanism for signal detection in sensory systems. In the case of hearing, we argue that active amplification of faint sounds is provided by a dynamical system which is…

Biological Physics · Physics 2009-11-06 Sebastien Camalet , Thomas Duke , Frank Julicher , Jacques Prost

Locating the source of odor in a turbulent environment - a common behavior for living organisms - is non-trivial because of the random nature of mixing. Here we analyze the statistical physics aspects of the problem and propose an efficient…

Chaotic Dynamics · Physics 2009-11-07 Eugene Balkovsky , Boris I. Shraiman

We numerically demonstrate a network of coupled oscillators that can learn to solve a classification task from a set of examples -- performing both training and inference through the nonlinear evolution of the system. We accomplish this by…

Mesoscale and Nanoscale Physics · Physics 2026-01-07 Daan de Bos , Marc Serra-Garcia
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