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Mammalian cell polarization and motility are important processes involved in many physiological and pathological phenomena, such as embryonic development, wound healing, and cancer metastasis. The traditional view of mammalian cell motility…

Soft Condensed Matter · Physics 2025-03-11 Winfried Schmidt , Walter Zimmermann , Chaouqi Misbah , Alexander Farutin

Active motion of molecules along filamentous structures is a crucial feature of cell biology and is often modeled with the paradigmatic asymmetric simple exclusion process. Motivated by recent experimental studies that have addressed the…

Statistical Mechanics · Physics 2018-09-19 Patrick Wilke , Emanuel Reithmann , Erwin Frey

The phase behavior of charged rods in the presence of inter-rod linkers is studied theoretically as a model for the equilibrium behavior underlying the organization of actin filaments by linker proteins in the cytoskeleton. The presence of…

Soft Condensed Matter · Physics 2016-08-31 Itamar Borukhov , Robijn F. Bruinsma , William M. Gelbart , Andrea J. Liu

In active matter systems, self-propelled particles can self-organize to undergo collective motion, leading to persistent dynamical behavior out of equilibrium. In cells, cytoskeletal filaments and motor proteins self-organize into complex…

Soft Condensed Matter · Physics 2020-05-19 Jeffrey M. Moore , Tyler N. Thompson , Matthew A. Glaser , Meredith D. Betterton

The origin of biological motion can be traced back to the function of molecular motor proteins. Cytoplasmic dynein and kinesin transport organelles within our cells moving along a polymeric filament, the microtubule. The motion of the…

Statistical Mechanics · Physics 2015-06-25 Imre Derenyi , Tamas Vicsek

Self-propulsion and navigation due to the sensing of environmental conditions - such as durotaxis and chemotaxis - are remarkable properties of biological cells that cannot be reproduced by single-component self-propelled particles. We…

Soft Condensed Matter · Physics 2024-06-03 Clara Abaurrea-Velasco , Thorsten Auth , Gerhard Gompper

Activity can organize matter in unique configurations inaccessible to equilibrium systems, including a sundry of spiraling shapes seen in nature that range from galaxies to living tissues to fossilized stromatolites. How these dynamic yet…

Soft Condensed Matter · Physics 2023-05-23 Xingting Gong , Manu Prakash

Cilia are motile biological appendages that are driven to bend by internal shear stresses between tubulin filaments. A continuum model of ciliary material is constructed that incorporates the essential ciliary constraints: (1)…

Soft Condensed Matter · Physics 2013-05-29 Mark A. Peterson

Coordinated cilia are used throughout the natural world for micronscale fluid transport. They are often modelled with regular filament arrays on fixed, planar surfaces. Here, we simulate hundreds of interacting active filaments on spherical…

Fluid Dynamics · Physics 2021-12-01 Timothy A Westwood , Eric E Keaveny

In this paper we study crawling locomotion based on directional frictional interactions, namely, frictional forces that are sensitive to the sign of the sliding velocity. Surface interactions of this type are common in biology, where they…

Mathematical Physics · Physics 2015-03-31 Paolo Gidoni , Giovanni Noselli , Antonio DeSimone

We study the over-damped dynamics of individual one-dimensional elastic filaments subjected to a chiral active force which propels each point of the filament at a fixed angle relative to the tangent vector of the filament at that point.…

Soft Condensed Matter · Physics 2026-03-09 Chanania Steinbock , Daniel A. Beller

Active matter systems comprise self-propelled particles that move on a substrate while leaving chemical trails that influence other particles through chemotaxis (e.g., slime-depositing bacteria). Orientational chemotaxis manifests as a…

Soft Condensed Matter · Physics 2025-12-11 Aymeric Lutier , Frédéric van Wijland , Jean-Baptiste Fournier

Active matter agents consume internal energy or extract energy from the environment for locomotion and force generation. Already rather generic models, such as ensembles of active Brownian particles, exhibit phenomena, which are absent at…

Soft Condensed Matter · Physics 2020-07-27 Roland G. Winkler , Gerhard Gompper

Confinement and wall effects are known to affect the kinematics and propulsive characteristics of swimming microorganisms. When a solid body is dragged through a viscous fluid at constant velocity, the presence of a wall increases fluid…

Biological Physics · Physics 2010-10-29 Arthur A. Evans , Eric Lauga

Filopodia are actin-rich structures, present on the surface of practically every known eukaryotic cell. These structures play a pivotal role in specific cell-cell and cell-matrix interactions by allowing cells to explore their environment,…

Cell spreading and motility on an adhesive substrate are driven by the active physical forces generated by the actin cytoskeleton. We have recently shown that coupling curved membrane complexes to protrusive forces, exerted by the actin…

Soft Condensed Matter · Physics 2023-04-04 Shubhadeep Sadhukhan , Samo Penič , Aleš Iglič , Nir Gov

We propose a mechanism of cell motility which is based on contraction and does not require protrusion. The contraction driven translocation of a cell is due to internal flow of the cytoskeleton generated by molecular motors. Each motor…

Biological Physics · Physics 2013-02-19 Pierre Recho , Thibault Putelat , Lev Truskinovsky

Hydra, a centimeter long cylindrical-shaped freshwater organism, has emerged as an interesting model system for studying morphogenesis in animals. Recently, fluorescent imaging of cytoskeletal actin filaments on the outer surface of hydra…

Soft Condensed Matter · Physics 2025-09-11 Sabyasachi Mukherjee , Anirban Sain

Motivated by the motion of nematode sperm cells, we present a model for the motion of an adhesive gel on a solid substrate. The gel polymerizes at the leading edge and depolymerizes at the rear. The motion results from a competition between…

Biological Physics · Physics 2009-11-10 Jean-Francois Joanny , Frank Julicher , Jacques Prost

Within biological fluid dynamics, it is conventional to distinguish between "puller" and "pusher" microswimmers on the basis of the forward or aft location of the flagella relative to the cell body: typically, bacteria are pushers and algae…

Soft Condensed Matter · Physics 2024-07-02 Praneet Prakash , Marco Vona , Raymond E. Goldstein
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