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In this paper, we consider the parameter estimation problem over sensor networks in the presence of quantized data and directed communication links. We propose a two-stage algorithm aiming at achieving the centralized sample mean estimate…

Systems and Control · Computer Science 2015-07-27 Shanying Zhu , Yeng Chai Soh , Lihua Xie

RNA molecules are known to form complex secondary structures including pseudoknots. A systematic framework for the enumeration, classification and prediction of secondary structures is critical to determine the biological significance of…

Biomolecules · Quantitative Biology 2025-12-24 Rayan Ibrahim , Allison H. Moore

We consider the inverse-folding problem for RNA secondary structures: for a given (pseudo-knot-free) secondary structure find a sequence that has that structure as its ground state. If such a sequence exists, the structure is called…

Biological Physics · Physics 2015-06-26 Bernd Burghardt , Alexander K. Hartmann

We consider entanglement purification protocols for multiple copies of qubit states. We use high-dimensional auxiliary entangled systems to learn about number and positions of errors in the noisy ensemble in an explicit and controlled way,…

Quantum Physics · Physics 2021-07-28 Ferran Riera Sàbat , Pavel Sekatski , Alexander Pirker , Wolfgang Dür

RNAs self-interact through hydrogen-bond base-pairing between nucleotides and fold into specific, stable structures that substantially govern their biochemical behaviour. Experimental characterization of these structures remains difficult,…

Quantum Physics · Physics 2023-05-02 Tristan Zaborniak , Juan Giraldo , Hausi Müller , Hosna Jabbari , Ulrike Stege

Consider the network of all secondary structures of a given RNA sequence, where nodes are connected when the corresponding structures have base pair distance one. The expected degree of the network is the average number of neighbors, where…

Biomolecules · Quantitative Biology 2014-11-04 Peter Clote

Computational RNA secondary structure prediction is rather well established. However, such prediction algorithms always depend on a large number of experimentally measured parameters. Here, we study how sensitive structure prediction…

Quantitative Methods · Quantitative Biology 2007-05-23 D. M. Layton , R. Bundschuh

Anomaly detection focuses on identifying samples that deviate from the norm. Discovering informative representations of normal samples is crucial to detecting anomalies effectively. Recent self-supervised methods have successfully learned…

Machine Learning · Computer Science 2025-09-22 Alain Ryser , Thomas M. Sutter , Alexander Marx , Julia E. Vogt

There is mounting evidence that existing neural network models, in particular the very popular sequence-to-sequence architecture, struggle to systematically generalize to unseen compositions of seen components. We demonstrate that one of…

Computation and Language · Computer Science 2022-03-23 Hao Zheng , Mirella Lapata

Ensembles of artificial neural networks show improved generalization capabilities that outperform those of single networks. However, for aggregation to be effective, the individual networks must be as accurate and diverse as possible. An…

Artificial Intelligence · Computer Science 2007-05-23 P. M. Granitto , P. F. Verdes , H. A. Ceccatto

Information processing techniques based on sparseness have been actively studied in several disciplines. Among them, a mathematical framework to approximately express a given dataset by a combination of a small number of basis vectors of an…

Information Theory · Computer Science 2016-05-04 Tomoyuki Obuchi , Yoshiyuki Kabashima

Training quantised neural networks (QNNs) is a non-differentiable optimisation problem since weights and features are output by piecewise constant functions. The standard solution is to apply the straight-through estimator (STE), using…

Machine Learning · Computer Science 2022-03-23 Matteo Spallanzani , Gian Paolo Leonardi , Luca Benini

With the increasing interest in Quantum Machine Learning, Quantum Neural Networks (QNNs) have emerged and gained significant attention. These models have, however, been shown to be notoriously difficult to train, which we hypothesize is…

Quantum Physics · Physics 2025-02-17 Sabrina Herbst , Sandeep Suresh Cranganore , Vincenzo De Maio , Ivona Brandic

Accurate prediction of RNA secondary structure underpins transcriptome annotation, mechanistic analysis of non-coding RNAs, and RNA therapeutic design. Recent gains from deep learning and RNA foundation models are difficult to interpret…

Biomolecules · Quantitative Biology 2026-03-25 Zhiyuan Chen , Zhenfeng Deng , Pan Deng , Yue Liao , Xiu Su , Peng Ye , Xihui Liu

Tracking tracer particles in heterogeneous environments plays an important role in unraveling the material properties. These heterogeneous structures are often static and depend on the sample realizations. Sample-to-sample fluctuations of…

Statistical Mechanics · Physics 2019-01-04 Takuma Akimoto , Eli Barkai , Keiji Saito

Ab initio RNA secondary structure predictions have long dismissed helices interior to loops, so-called pseudoknots, despite their structural importance. Here, we report that many pseudoknots can be predicted through long time scales RNA…

Biological Physics · Physics 2009-11-10 A. Xayaphoummine , T. Bucher , F. Thalmann , H. Isambert

We argue from the point of view of statistical inference that the quantum relative entropy is a good measure for distinguishing between two quantum states (or two classes of quantum states) described by density matrices. We extend this…

Quantum Physics · Physics 2009-10-30 V. Vedral , M. B. Plenio , K. Jacobs , P. L. Knight

New measures for the quantization of systems with constraints are discussed and applied to several examples, in particular, examples of alternative but equivalent formulations of given first-class constraints, as well as a comparison of…

Quantum Physics · Physics 2007-05-23 John R. Klauder

We propose and develop a new procedure, whereby a quantum system can learn to anneal to a desired ground state. We demonstrate successful learning to produce an entangled state for a two-qubit system, then demonstrate generalizability to…

Quantum Physics · Physics 2017-04-27 E. C. Behrman , J. E. Steck , M. A. Moustafa

Ensemble methods are known for enhancing the accuracy and robustness of machine learning models by combining multiple base learners. However, standard approaches like greedy or random ensembling often fall short, as they assume a constant…

Machine Learning · Computer Science 2025-06-24 Sebastian Pineda Arango , Maciej Janowski , Lennart Purucker , Arber Zela , Frank Hutter , Josif Grabocka