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The dielectric characterization of human tissues can play a crucial role in the development of new medical diagnostic tools. In particular, the characterization of healthy and pathological tissues can provide vital information for…

Signal Processing · Electrical Eng. & Systems 2026-01-28 Sergio Micó-Rosa , Concepcion Garcia-Pardo , Matteo Frasson , Narcis Cardona , Vicente Pons-Beltrán , Pedro López-Muñoz

Imaging Raman spectroscopy can be used to identify cancerous tissue. Traditionally, a step-by-step scanning of the sample is applied to generate a Raman image, which, however, is too slow for routine examination of patients. By transferring…

Instrumentation and Methods for Astrophysics · Physics 2018-10-09 Elmar Schmälzlin , Benito Moralejo , Ingo Gersonde , Johannes Schleusener , Maxim E. Darvin , Gisela Thiede , Martin M. Roth

Ultrasound is a useful technique for diagnosing thyroid nodules. Benign and malignant nodules that automatically discriminate in the ultrasound pictures can provide diagnostic recommendations or, improve diagnostic accuracy in the absence…

Computer Vision and Pattern Recognition · Computer Science 2024-09-05 Ponugoti Nikhila , Sabari Nathan , Elmer Jeto Gomes Ataide , Alfredo Illanes , Michael Friebe , Srichandana Abbineni

Infrared (IR) dyes, especially those within the near-infrared (NIR) spectrum, offer substantial advantages for in vivo imaging, owing to their deep tissue penetration and minimal background autofluorescence. Nanoparticles incorporating…

Medical Physics · Physics 2024-11-07 Michael Adeniyi

Artificial intelligence represents a new frontier in human medicine that could save more lives and reduce the costs, thereby increasing accessibility. As a consequence, the rate of advancement of AI in cancer medical imaging and more…

In biological microscopy, light scattering represents the main limitation to image at depth. Recently, a set of wavefront shaping techniques has been developed in order to manipulate coherent light in strongly disordered materials. The…

Optics · Physics 2021-01-07 Antoine Boniface , Jonathan Dong , Sylvain Gigan

Total internal reflection fluorescence (TIRF) microscopy and its variants are key technologies for visualizing the dynamics of single molecules or organelles in live cells. Yet, truely quantitative TIRF remains problematic. One unknown…

Biological Physics · Physics 2017-06-07 Maia Brunstein , Lopamudra Roy , Martin Oheim

Objective: Survival rate of oral squamous cell carcinoma (OSCC) patients is very poor and can be improved using highly sensitive, specific and accurate techniques. Autofluorescence and fluorescence techniques are very sensitive and useful…

Histological analysis of tissue samples is one of the most widely used methods for disease diagnosis. After taking a sample from a patient, it goes through a lengthy and laborious preparation, which stains the tissue to visualize different…

Computer Vision and Pattern Recognition · Computer Science 2019-03-05 Yair Rivenson , Hongda Wang , Zhensong Wei , Yibo Zhang , Harun Gunaydin , Aydogan Ozcan

Current methods for diagnosing the progression of multiple types of cancer within patients rely on interpreting stained needle biopsies. This process is time-consuming and susceptible to error throughout the paraffinization, Hematoxylin and…

Image and Video Processing · Electrical Eng. & Systems 2022-04-19 Benjamin Paulson , Theodore Colwell , Natalia Bukowski , Joseph Weller , Andrew Crisler , John Cisler , Alexander Drobek , Alexander Neuwirth

A disordered structure embedding an active gain material and able to lase is called random laser (RL). The RL spectrum may appear either like a set of sharp resonances or like a smooth line superimposed to the fluorescence. A recent letter…

Optics · Physics 2015-06-03 M. Leonetti , C. Conti , C. Lopez

Fluorescence microscopy is a powerful tool for imaging biological samples with molecular specificity. In contrast, phase microscopy provides label-free measurement of the sample's refractive index (RI), which is an intrinsic optical…

Optics · Physics 2022-01-26 Yi Xue , David Ren , Laura Waller

The method of microwave radiometry is one of the areas of medical diagnosis of breast cancer. It is based on analysis of the spatial distribution of internal and surface tissue temperatures, which are measured in the microwave (RTM) and…

Quantitative Methods · Quantitative Biology 2019-10-08 Vladislav Levshinskii , Maxim Polyakov , Alexander Losev , Alexander Khoperskov

Currently, diagnostic medicine uses a multitude of tools ranging from ionising radiation to histology analysis. With advances in piezoelectric crystal technology, high-frequency ultrasound imaging has developed to achieve comparatively high…

Medical Physics · Physics 2022-01-13 Akhil Kallepalli , James Halls , David B. James , Mark A. Richardson

Spatial Frequency Domain Imaging can map tissue scattering and absorption properties over a wide field of view, making it useful for clinical applications such as wound assessment and surgical guidance. This technique has previously…

Biological Physics · Physics 2021-02-24 Mason T. Chen , Melina Papadakis , Nicholas J. Durr

The tumour microenvironment (TME) strongly influences tumorigenesis and metastasis. Two of the most characterized properties of the TME are acidosis and hypoxia, both of which are considered hallmarks of tumours as well as critical factors…

Thyroid cancer is the most common endocrine malignancy, and accurately distinguishing between benign and malignant thyroid tumors is crucial for developing effective treatment plans in clinical practice. Pathologically, thyroid tumors pose…

Image and Video Processing · Electrical Eng. & Systems 2024-01-04 Jia Dong , Yao Yao , Yang Dong , Hui Ma

In this study, a radiomics approach was extended to optical fluorescence molecular imaging data for tissue classification, termed 'optomics'. Fluorescence molecular imaging is emerging for precise surgical guidance during head and neck…

Fluorescence microscopic imaging in centimeter-deep tissue has been highly sought-after for many years because much interesting in vivo micro-information, such as microcirculation, tumor angiogenesis, and metastasis, may deeply locate in…

Cancer is an epidemic worldwide. At present one in four persons has cancer and this statistic will change to one in a two person in the near future. It is now known that war against cancer is the early, curable detection and treatment.…

Tissues and Organs · Quantitative Biology 2017-10-03 Shiva Bhandari , Sri Choudannavar , Ethan Avery , Peeyush Sahay , Prabhakar Pradhan