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Current pain assessment within hospitals often relies on self-reporting or non-specific EKG vital signs. This system leaves critically ill, sedated, and cognitively impaired patients vulnerable to undertreated pain and opioid overuse.…
Modern imaging techniques for probing brain function, including functional Magnetic Resonance Imaging, intrinsic and extrinsic contrast optical imaging, and magnetoencephalography, generate large data sets with complex content. In this…
Using a realistic model of activity dependent dynamical synapses and a standard integrate and fire neuron model we study, both analytically and numerically, the conditions in which a postsynaptic neuron efficiently detects temporal…
Understanding how neural dynamics shape cognitive experiences remains a central challenge in neuroscience and psychiatry. Here, we present a novel framework leveraging state-to-output controllability from dynamical systems theory to model…
The cerebral cortex spontaneously displays different patterns of activity that evolve over time according to the brain state. Sleep, wakefulness, resting states, and attention are examples of a wide spectrum of physiological states that can…
Electroencephalography (EEG) is a tool that allows us to analyze brain activity with high temporal resolution. These measures, combined with deep learning and digital signal processing, are widely used in neurological disorder detection and…
Brain-computer interfaces (BCIs) often suffer from limited robustness and poor long-term adaptability. Model performance rapidly degrades when user attention fluctuates, brain states shift over time, or irregular artifacts appear during…
Epilepsy is a common neurological disorder characterized by recurrent seizures accompanied by excessive synchronous brain activity. The process of structural and functional brain alterations leading to increased seizure susceptibility and…
It is widely assumed that neural activity related to synchronous rhythms of large portions of neurons in specific locations of the brain is responsible for the pathology manifested in patients' uncontrolled tremor and other similar…
Interactions in nature can be described by their coupling strength, direction of coupling and coupling function. The coupling strength and directionality are relatively well understood and studied, at least for two interacting systems,…
Current models treat physiological signals as noise corrupting neural computation. Previously, we showed that removing these "artifacts" eliminates 70% of predictive correlation, suggesting body signals functionally drive cognition. Here,…
Deficit of attention, anxiety, sleep disorders are some of the problems which affect many persons. As these issues can evolve into severe conditions, more factors should be taken into consideration. The paper proposes a conception which…
In our earlier study dealing with the analysis of neuromagnetic responses (magnetoencephalograms - MEG) to flickering-color stimuli for a group of control human subjects (9 volunteers) and a patient with photosensitive epilepsy (a 12-year…
Generally, blinks are treated on equal with artifacts and noise while analyzing EEG signals. However, blinks carry important information about mental processes and thus it is important to detect blinks accurately. The aim of the presented…
Understanding how human brains interpret and process information is important. Here, we investigated the selectivity and inter-individual differences in human brain responses to images via functional MRI. In our first experiment, we found…
The effects of nonlocal and reflecting connectivities have been previously investigated in coupled Leaky Integrate-and-Fire (LIF) elements, which assimilate the exchange of electrical signals between neurons. In this work we investigate the…
A method to upsample insufficiently sampled experimental time series of pseudo-periodic signals is proposed. The result is an estimate of the pseudo-periodic cycle underlying the signal. This hypersampling requires a sufficiently sampled…
A healthy human brain is perfused with blood flowing laminarly through cerebral vessels, providing brain tissue with substrates such as oxygen and glucose. Under normal conditions, cerebral blood flow is controlled by autoregulation as well…
Brain networks typically exhibit characteristic synchronization patterns where several synchronized clusters coexist. On the other hand, neurological disorders are considered to be related to pathological synchronization such as excessive…
Criticality has been conjectured as an integral part of neuronal network dynamics. Operating at a critical threshold requires precise parameter tuning and a corresponding mechanism remains an open question. Recent studies have suggested…