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Darwinian evolution can be illustrated as an uphill walk in a landscape, where the surface consists of genotypes, the height coordinates represent fitness, and each step corresponds to a point mutation. Epistasis, roughly defined as the…

Quantitative Methods · Quantitative Biology 2013-05-08 Kristina Crona

The contribution to an organism's phenotype from one genetic locus may depend upon the status of other loci. Such epistatic interactions among loci are now recognized as fundamental to shaping the process of adaptation in evolving…

Populations and Evolution · Quantitative Biology 2012-12-18 Jeremy A. Draghi , Joshua B. Plotkin

Biochemical and regulatory interactions central to biological networks are expected to cause extensive genetic interactions or epistasis affecting the heritability of complex traits and the distribution of genotypes in populations. However,…

Populations and Evolution · Quantitative Biology 2009-12-15 Richard A. Neher , Boris I. Shraiman

Epistasis describes the phenomenon that mutations at different loci do not have independent effects with regard to certain phenotypes. Understanding the global epistatic landscape is vital for many genetic and evolutionary theories. Current…

Molecular Networks · Quantitative Biology 2015-02-11 Brandon Barker , Lin Xu , Zhenglong Gu

The mean-field thermodynamic limit is studied for a class of isolated Newtonian N-body systems whose Hamiltonian admits several invariants of motion. It is shown that the macrostates of individual members of a statistical equilibrium…

Mathematical Physics · Physics 2009-11-13 Michael K. -H. Kiessling

Equilibrium statistical physics is considered from the point of view of statistical estimation theory. This involves the notions of statistical model, of estimators, and of exponential family. A useful property of the latter is the…

Statistical Mechanics · Physics 2016-08-31 Jan Naudts

Dominance is usually considered a constant value that describes the relative difference in fitness or phenotype between heterozygotes and the average of homozygotes at a focal polymorphic locus. However, the observed dominance can vary with…

Populations and Evolution · Quantitative Biology 2023-12-05 Juan Li , Claudia Bank

We investigate the evolutionary dynamics of a population structured in phenotype, subjected to trait dependent selection with a linearly moving optimum and an asexual mode of reproduction. Our model consists of a non-local and non-linear…

Analysis of PDEs · Mathematics 2021-12-09 Raphaël Forien , Jimmy Garnier , Florian Patout

We present an application of the theory of stochastic processes to model and categorize non-equilibrium physical phenomena. The concepts of uniformly continuous probability measures and modular evolution lead to a systematic hierarchical…

Mathematical Physics · Physics 2009-08-18 Enrique Hernandez-Lemus , Jesus K. Estrada-Gil

The fitness contribution of an allele at one genetic site may depend on alleles at other sites, a phenomenon known as epistasis. Epistasis can profoundly influence the process of evolution in populations under selection, and can shape the…

Populations and Evolution · Quantitative Biology 2015-06-11 Premal Shah , David M. McCandlish , Joshua B. Plotkin

We are interested in modelling Darwinian evolution, resulting from the interplay of phenotypic variation and natural selection through ecological interactions. Our models are rooted in the microscopic, stochastic description of a population…

Probability · Mathematics 2016-08-16 Nicolas Champagnat , Régis Ferrière , Sylvie Méléard

The aim of this work is to put forward a statistical mechanics theory of social interaction, generalizing econometric discrete choice models. After showing the formal equivalence linking econometric multinomial logit models to equilibrium…

Physics and Society · Physics 2009-07-16 Ignacio Gallo

The statistical mechanics of a one-dimensional Ising model in thermal equilibrium is well-established, textbook material. Yet, when driven far from equilibrium by coupling two sectors to two baths at different temperatures, it exhibits…

Statistical Mechanics · Physics 2014-12-09 Nicholas Borchers , Michel Pleimling , R. K. P. Zia

Every now and then the cultural paradigm of a society changes. Human history can be regarded as a sequence of long periods of cultural stasis punctuated by paradigm shifts that transform culture upside-down over the turn of a few…

Physics and Society · Physics 2020-06-04 Ignacio Pascual , Jacobo Aguirre , Susanna Manrubia , José A. Cuesta

One of the most used metrics to gauge the effects of climate change is the equilibrium climate sensitivity, defined as the long-term (equilibrium) temperature increase resulting from instantaneous doubling of atmospheric CO$_2$. Since…

Atmospheric and Oceanic Physics · Physics 2021-02-04 Robbin Bastiaansen , Henk A. Dijkstra , Anna S. von der Heydt

We introduce the Eggbox Ising model, a tunable construction of rugged energy landscapes defined by distances to a prescribed set of patterns. Correlated pattern ensembles realize arbitrary k-step replica-symmetry-breaking structures and…

Statistical Mechanics · Physics 2026-02-20 Mutian Shen , Yichen Xu , Zohar Nussinov

We extend our study of a simple model of biological coevolution to its statistical properties. Staring with a complete description in terms of a master equation, we provide its relation to the deterministic evolution equations used in…

Populations and Evolution · Quantitative Biology 2007-05-23 R. K. P. Zia , Per Arne Rikvold

We derive an equilibrium statistical theory for the macroscopic description of a ferromagnetic material at positive finite temperatures. Our formulation describes the most-probable equilibrium macrostates that yield a coherent deterministic…

Materials Science · Physics 2007-05-23 Markos A. Katsoulakis , Petr Plechac

The random field Ising model with Gaussian disorder is studied using a new Monte Carlo algorithm. The algorithm combines the advantanges of the replica exchange method and the two-replica cluster method and is much more efficient than the…

Statistical Mechanics · Physics 2009-10-31 Jon Machta , Mark Newman , Lincoln Chayes

The scaling behavior of the entanglement entropy in the two-dimensional random transverse field Ising model is studied numerically through the strong disordered renormalization group method. We find that the leading term of the entanglement…

Disordered Systems and Neural Networks · Physics 2009-11-13 Rong Yu , Hubert Saleur , Stephan Haas