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Biological cells are built up from many different constituents of varying size and stiffness which all contribute to the cell's mechanical properties. Despite this heterogeneity, in the analysis of experimental measurements such as atomic…

Biological Physics · Physics 2023-05-18 Sebastian Wohlrab , Sebastian J. Müller , Stephan Gekle

We present a simple, and physically motivated, coarse-grained model of a lipid bilayer, suited for micron scale computer simulations. Each ~25 nm^2 patch of bilayer is represented by a spherical particle. Mimicking forces of hydrophobic…

Soft Condensed Matter · Physics 2015-05-13 Andrea Pasqua , Lutz Maibaum , George Oster , Daniel A. Fletcher , Phillip L. Geissler

We examine the budding of a nanoscale particle through a lipid bilayer using molecular dynamics simulations, free energy calculations, and an elastic theory, with the aim of determining the extent to which equilibrium elasticity theory can…

Subcellular Processes · Quantitative Biology 2012-02-22 Teresa Ruiz-Herrero , Enrique Velasco , Michael F. Hagan

We present Monte Carlo simulations of an ultra coarse-grained lipid bilayer with different number of lipids on both leaflets. In the simulations, we employ a new method for measuring the elastic parameters of the membrane, including the…

Soft Condensed Matter · Physics 2025-05-20 Oded Farago

The electrostatic contribution to spontaneous membrane curvature is calculated within Poisson-Boltzmann theory under a variety of assumptions and emphasizing parameters in the physiological range. Asymmetric surface charges, either fixed…

Condensed Matter · Physics 2009-10-28 Tom Chou , Marko V. Jaric' , Eric D. Siggia

We review recent ab initio molecular dynamics studies of electrode/electrolyte interfaces in lithium ion batteries. Our goals are to introduce experimentalists to simulation techniques applicable to models which are arguably most faithful…

Materials Science · Physics 2013-04-23 Kevin Leung

We perform a variational analysis of an elastic membrane spanning a closed curve which may sustain bending and torsion. First, we deal with parametrized curves and linear elastic membranes proving the existence of equilibria and finding…

Analysis of PDEs · Mathematics 2024-06-28 Francesco Ballarin , Giulia Bevilacqua , Luca Lussardi , Alfredo Marzocchi

In linear elastic theory, membrane deformation energy caused by inclusions (e.g., membrane-spanning peptides in lipid bilayers) can be rigorously presented in terms of coupled harmonic oscillators. The general expressions for the…

Biological Physics · Physics 2007-05-23 Yury S. Neustadt , Michael B. Partenskii

Excitable membranes are an important type of nonlinear dynamical system and their study can be used to provide a connection between physical and biological circuits. We discuss two models of excitable membranes important in cardiac and…

Biological Physics · Physics 2012-12-18 Jarrett L. Lancaster , Esther M. Leise , Edward H. Hellen

The generation of action potential brings into play specific mechanosensory stimuli manifest in the variation of membrane capacitance, resulting from the selective membrane permeability to ions exchanges and testifying to the central role…

Neurons and Cognition · Quantitative Biology 2021-02-23 Alain M. Dikande

Constancy of life vitally depends on the internalization of particles through biomembranes. Of particular interest, cellular uptake, including phagocytosis, receptor-mediated endocytosis, and membrane fusion, critically depends on the…

Soft Condensed Matter · Physics 2026-01-07 Amir Khosravanizadeh , Pierre Sens , Farshid Mohammad-Rafiee

Biological cells embedded in fibrous matrices have been observed to form inter-cellular bands of dense and aligned fibers, through which they mechanically interact over long distances. Such matrix-mediated cellular interactions have been…

Biological Physics · Physics 2018-11-14 Ran S Sopher , Hanan Tokash , Sari Natan , Mirit Sharabi , Ortal Shelah , Oren Tchaicheeyan , Ayelet Lesman

This chapter summarizes several approaches combining theory, simulation and experiment that aim for a better understanding of phenomena in lipid bilayers and membrane protein systems, covering topics such as lipid rafts, membrane mediated…

Biological Physics · Physics 2014-12-17 Markus Deserno , Kurt Kremer , Harald Paulsen , Christine Peter , Friederike Schmid

Analogies between mechanical and electrical systems have been developed and applied for almost a century, and they have proved their usefulness in the study of mechanical and electrical systems. The development of new elements such as the…

Systems and Control · Electrical Eng. & Systems 2020-09-03 Javier López-Martínez , Javier Martínez , Daniel García-Vallejo , Alfredo Alcayde , Francisco G. Montoya

Electrical conductivity is one of the most commonly used geophysical method for reservoir and environmental studies. Its main interest lies in its sensitivity to key properties of storage and transport in porous media. Its quantitative use…

Geophysics · Physics 2019-08-29 Luong Duy Thanh , Damien Jougnot , Phan Van Do , Nguyen Van Nghia A

This essay is a recapitulation of an earlier Kramers-Kronig analysis of biological tissue, published in 2010, "Kramers-Kronig analysis of biological skin". The intent is to both complement and bolster the antecedent analysis by furnishing…

Tissues and Organs · Quantitative Biology 2011-12-22 Luisiana X. Cundin

An elastic bilayer, consisting of an equibiaxially pre-stretched sheet bonded to a stress-free one, spontaneously morphs into curved shapes in the absence of external loads or constraints. Using experiments and numerical simulations, we…

Soft Condensed Matter · Physics 2018-11-28 Noè Caruso , Aleksandar Cvetković , Alessandro Lucantonio , Giovanni Noselli , Antonio DeSimone

Polymer electrolytes (PEs) are promising candidates for use in next-generation high-voltage batteries, as they possess advantageous elastic and electrochemical properties. However, PEs still suffer from low ionic conductivity and need to be…

Cellular membranes are elastic lipid bilayers that contain a variety of proteins, including ion channels, receptors, and scaffolding proteins. These proteins are known to diffuse in the plane of the membrane and to influence the bending of…

Soft Condensed Matter · Physics 2020-10-28 Arijit Mahapatra , David Saintillan , Padmini Rangamani

Intracellular recordings of neuronal membrane potential are a central tool in neurophysiology. In many situations, especially in vivo, the traditional limitation of such recordings is the high electrode resistance, which may cause…

Neurons and Cognition · Quantitative Biology 2007-11-15 R. Brette , Z. Piwkowska , M. Rudolph-Lilith , T. Bal , A. Destexhe