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A representation of frequency of strings of length K in complete genomes of many organisms in a square has led to seemingly self-similar patterns when K increases. These patterns are caused by under-represented strings with a certain…

Biological Physics · Physics 2015-06-26 Zu-Guo Yu , Bai-lin Hao , Hui-min Xie , Guo-Yi Chen

Background: The trend towards large-scale studies including population imaging poses new challenges in terms of quality control (QC). This is a particular issue when automatic processing tools, e.g. image segmentation methods, are employed…

A stretched DNA molecule which is also under- or overwound, undergoes a buckling transition forming intertwined looped domains called plectonemes. Here we develop a simple theory that extends the two-phase model of stretched supercoiled…

Soft Condensed Matter · Physics 2024-11-01 Midas Segers , Enrico Skoruppa , Helmut Schiessel , Enrico Carlon

We prove that a positive-definite measure in $\mathbb{R}^n$ with uniformly discrete support and discrete closed spectrum, is representable as a finite linear combination of Dirac combs, translated and modulated. This extends our recent…

Classical Analysis and ODEs · Mathematics 2017-06-01 Nir Lev , Alexander Olevskii

In biomedical imaging reliable segmentation of objects (e.g. from small cells up to large organs) is of fundamental importance for automated medical diagnosis. New approaches for multi-scale segmentation can considerably improve performance…

Numerical Analysis · Mathematics 2016-10-04 Leonie Zeune , Guus van Dalum , Leon W. M. M. Terstappen , S. A. van Gils , Christoph Brune

Optical spectrometers are fundamental across numerous disciplines in science and technology. However, miniaturized versions, while essential for in situ measurements, are often restricted to coarse identification of signature peaks and…

We explore statistical fluctuations over the ensemble of quantum trajectories in a model of two-dimensional free fermions subject to projective monitoring of local charge across the measurement-induced phase transition. Our observables are…

Quantum Physics · Physics 2026-02-11 Igor Poboiko , Igor V. Gornyi , Alexander D. Mirlin

In this paper, we aim to give a tutorial for undergraduate students studying statistical methods and/or bioinformatics. The students will learn how data visualization can help in genomic sequence analysis. Students start with a fragment of…

Quantitative Methods · Quantitative Biology 2008-01-17 A. N. Gorban , A. Y. Zinovyev

Modern single-cell flow and mass cytometry technologies measure the expression of several proteins of the individual cells within a blood or tissue sample. Each profiled biological sample is thus represented by a set of hundreds of…

Machine Learning · Computer Science 2022-06-29 Siyuan Shan , Vishal Baskaran , Haidong Yi , Jolene Ranek , Natalie Stanley , Junier Oliva

We develop the tools necessary to assess the statistical significance of resonant features in the CMB correlation functions, combining power spectrum and bispectrum measurements. This significance is typically addressed by running a large…

Cosmology and Nongalactic Astrophysics · Physics 2016-03-02 P. Daniel Meerburg , Moritz Münchmeyer , Benjamin Wandelt

A novel approach towards the spectral analysis of stationary random bivariate signals is proposed. Using the Quaternion Fourier Transform, we introduce a quaternion-valued spectral representation of random bivariate signals seen as…

Methodology · Statistics 2017-11-22 Julien Flamant , Nicolas Le Bihan , Pierre Chainais

DNA supercoiling, the under or overwinding of DNA, is a key physical mechanism both participating to compaction of bacterial genomes and making genomic sequences adopt various structural forms. DNA supercoiling may lead to the formation of…

Biological Physics · Physics 2019-06-26 Thibaut Lepage , Ivan Junier

Bioinformatics, which is now a well known field of study, originated in the context of biological sequence analysis. Recently graphical representation takes place for the research on DNA sequence. Research in biological sequence is mainly…

Data Structures and Algorithms · Computer Science 2022-11-28 Probir Mondal

It is basic question in biology and other fields to identify the char- acteristic properties that on one hand are shared by structures from a particular realm, like gene regulation, protein-protein interaction or neu- ral networks or…

Quantitative Methods · Quantitative Biology 2012-10-19 Anirban Banerjee , Jürgen Jost

This paper presents a probabilistic approach for DNA sequence analysis. A DNA sequence consists of an arrangement of the four nucleotides A, C, T and G and different representation schemes are presented according to a probability measure…

Quantitative Methods · Quantitative Biology 2010-02-12 Amrita Priyam , B. M. Karan , G. Sahoo

A hypercomplex representation of DNA is proposed to facilitate comparison of DNA sequences with fuzzy composition. Using hypercomplex number representation, conventional sequence analysis method, such as, dot matrix analysis, dynamic…

Quantitative Methods · Quantitative Biology 2023-08-03 Jian-Jun Shu , Yajing Li

We give a Herglotz-type representation of an arbitrary generalized spectral measure. As an application, a new proof of the classical Naimark's dilation theorem is given. The same approach is used to describe the spectrum of all unitary…

Functional Analysis · Mathematics 2009-10-22 Mishko Mitkovski

We present a generalization of continuous position measurements that accounts for a spatially inhomogeneous measurement strength. This describes many real measurement scenarios, in which the rate at which information is extracted about…

Quantum Physics · Physics 2015-05-20 Jonathan B. Mackrory , Kurt Jacobs , Daniel A. Steck

This work presents the first steps to modelling synthetic rovibrational spectra for all molecules of astrophysical interest using a new approach implemented in the Prometheus code. The goal is to create a new comprehensive source of…

Chemical Physics · Physics 2022-02-02 Thomas M. Cross , David M. Benoit , Marco Pignatari , Brad K. Gibson

In a multicellular organism different cell types express a gene in different amounts. Samples from which gene expression levels can be measured typically contain a mixture of different cell types, the resulting measurements thus give only…

Quantitative Methods · Quantitative Biology 2017-08-09 Nico Riedel , Johannes Berg