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Data poisoning is one of the most relevant security threats against machine learning and data-driven technologies. Since many applications rely on untrusted training data, an attacker can easily craft malicious samples and inject them into…

Cryptography and Security · Computer Science 2021-12-01 Nicolas M. Müller , Simon Roschmann , Konstantin Böttinger

The effect of secondary structure on DNA duplex formation is poorly understood. We use a coarse-grained model of DNA to show that specific 3- and 4-base pair hairpins reduce hybridization rates by factors of 2 and 10 respectively, in good…

Soft Condensed Matter · Physics 2015-12-15 John S. Schreck , Thomas E. Ouldridge , Flavio Romano , Petr Sulc , Liam Shaw , Ard A. Louis , Jonathan P. K. Doye

Condensation of hundreds of mega-base-pair-long human chromosomes in a small nuclear volume is a spectacular phenomenon. This process is driven by the formation of chromosome loops. ATP consuming motor, condensin, interacts with chromatin…

Soft Condensed Matter · Physics 2021-10-27 Ryota Takaki , Atreya Dey , Guang Shi , Dave Thirumalai

The interplay between bending of the molecule axis and appearance of disruptions in circular DNA molecules, with $\sim 100$ base pairs, is addressed. Three minicircles with different radii and almost equal content of AT and GC pairs are…

Soft Condensed Matter · Physics 2014-06-03 Marco Zoli

Statistical DNA models available in the literature are often effective models where the base-pair state only (unbroken or broken) is considered. Because of a decrease by a factor of 30 of the effective bending rigidity of a sequence of…

Soft Condensed Matter · Physics 2008-01-28 John Palmeri , Manoel Manghi , Nicolas Destainville

The phase diagram of a water solution of DNA and oppositely charged spherical macroions is studied. DNA winds around spheres to form beads-on-a-string complexes resembling the chromatin 10 nm fiber. At small enough concentration of spheres…

Soft Condensed Matter · Physics 2009-11-07 Toan T. Nguyen , Boris I. Shklovskii

We study a class of micromanipulation experiments, exemplified by the pulling apart of the two strands of double-stranded DNA (dsDNA). When the pulling force is increased to a critical value, an ``unzipping'' transition occurs. For random…

Soft Condensed Matter · Physics 2009-10-31 David K. Lubensky , David R. Nelson

The paper introduces the concept of a cluster structure to define a joint distribution of the sample size and its exchangeable random partitions. The cluster structure allows the probability distribution of the random partitions of a subset…

Methodology · Statistics 2013-10-08 Mingyuan Zhou

While state-of-the-art diffusion models (DMs) excel in image generation, concerns regarding their security persist. Earlier research highlighted DMs' vulnerability to data poisoning attacks, but these studies placed stricter requirements…

Machine Learning · Computer Science 2024-06-18 Zhuoshi Pan , Yuguang Yao , Gaowen Liu , Bingquan Shen , H. Vicky Zhao , Ramana Rao Kompella , Sijia Liu

While the behavior of double stranded DNA at mesoscopic scales is fairly well understood, less is known about its relation to the rich mechanical properties in the base-pair scale, which is crucial, for instance, to understand DNA-protein…

Soft Condensed Matter · Physics 2025-02-03 Yair Augusto Gutierrez Fosado , Fabio Landuzzi , Takahiro Sakaue

A model of arsenic clustering in silicon is proposed and analyzed. The main feature of the proposed model is the assumption that negatively charged arsenic complexes play a dominant role in the clustering process. To confirm this…

Materials Science · Physics 2009-11-11 F. F. Komarov , O. I. Velichko , V. A. Dobrushkin , A. M. Mironov

The effective DNA-DNA interaction force is calculated by computer simulations with explicit tetravalent counterions and monovalent salt. For overcharged DNA molecules, the interaction force shows a double-minimum structure. The positions…

Biomolecules · Quantitative Biology 2009-11-10 E. Allahyarov , G. Gompper , H. Löwen

Poisoning-based backdoor attacks pose significant threats to deep neural networks by embedding triggers in training data, causing models to misclassify triggered inputs as adversary-specified labels while maintaining performance on clean…

Cryptography and Security · Computer Science 2026-04-24 Yuchen Shi , Xin Guo , Huajie Chen , Tianqing Zhu , Bo Liu , Wanlei Zhou

The ability of double-stranded DNA or RNA to locally melt and form kinks leads to strong non-linear elasticity effects that qualitatively affect their packing in confined spaces. Using analytical theory and numerical simulation we show that…

Soft Condensed Matter · Physics 2024-10-14 James Farrell , Jure Dobnikar , Rudolf Podgornik , Tine Curk

Model-based clustering is widely-used in a variety of application areas. However, fundamental concerns remain about robustness. In particular, results can be sensitive to the choice of kernel representing the within-cluster data density.…

Machine Learning · Statistics 2019-06-27 Leo L Duan , David B Dunson

We consider the influence of a terahertz field on the breathing dynamics of double-stranded DNA. We model the spontaneous formation of spatially localized openings of a damped and driven DNA chain, and find that linear instabilities lead to…

Biological Physics · Physics 2010-01-27 B. S. Alexandrov , V. Gelev , A. R. Bishop , A. Usheva , K. O. Rasmussen

Clustering is one of the most complex phenomena known to the structure of atomic nuclei. A comprehensive description of this ubiquitous phenomenon goes beyond standard shell model and cluster model frameworks. We argue that clustering is a…

Nuclear Theory · Physics 2015-06-04 J. Okolowicz , M. Ploszajczak , W. Nazarewicz

We study numerically a disordered version of the model for DNA denaturation transition (DSAW-DNA) consisting of two interacting SAWs in 3d, which undergoes a first order transition in the homogeneous case. The two possible values eAT and…

Soft Condensed Matter · Physics 2009-11-11 Barbara Coluzzi

The theoretical approach to a sequential heavy ion double charge exchange reaction is presented. A brief introduction into the formal theory of second-order nuclear reactions and their application to Double Single Charge Exchange (DSCE)…

Nuclear Theory · Physics 2021-04-13 Horst Lenske , Jessica Bellone , Maria Colonna , Danilo Gambacurta

We propose an inclusive approach for calculating characteristics of secondary electrons produced by ions/protons in tissue-like media. This approach is based on an analysis of the projectile's interaction with the medium on the microscopic…

Biological Physics · Physics 2009-11-13 E. Surdutovich , O. I. Obolensky , E. Scifoni , I. Pshenichnov , I. Mishustin , A. V. Solov'yov , W. Greiner