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Recent calculations further supports the premise that large-scale synchronous firings of neurons may affect molecular processes. The context is scalp electroencephalography (EEG) during short-term memory (STM) tasks. The mechanism…

Neurons and Cognition · Quantitative Biology 2016-02-03 Lester Ingber

This paper focuses on how bottom-up neocortical models can be developed into eigenfunction expansions of probability distributions appropriate to describe short-term memory in the context of scalp EEG. The mathematics of eigenfunctions are…

Biological Physics · Physics 2007-05-23 Lester Ingber

A statistical mechanics of neuronal interactions (SMNI) is explored as providing some substance to a physiological basis of the g factor. Some specific elements of SMNI, previously used to develop a theory of short-term memory (STM) and a…

Biological Physics · Physics 2007-05-23 Lester Ingber

This paper describes a framework for modeling the interface between perception and memory on the algorithmic level of analysis. It is consistent with phenomena associated with many different brain regions. These include view-dependence (and…

Neural and Evolutionary Computing · Computer Science 2015-12-29 Joel Z. Leibo , Julien Cornebise , Sergio Gómez , Demis Hassabis

A series of papers has developed a statistical mechanics of neocortical interactions (SMNI), deriving aggregate behavior of experimentally observed columns of neurons from statistical electrical-chemical properties of synaptic interactions.…

Biological Physics · Physics 2009-11-06 Lester Ingber

There are several kinds of non-invasive imaging methods that are used to collect data from the brain, e.g., EEG, MEG, PET, SPECT, fMRI, etc. It is difficult to get resolution of information processing using any one of these methods.…

Computational Engineering, Finance, and Science · Computer Science 2007-07-13 Lester Ingber

A series of papers has developed a statistical mechanics of neocortical interactions (SMNI), deriving aggregate behavior of experimentally observed columns of neurons from statistical electrical-chemical properties of synaptic interactions.…

Biological Physics · Physics 2007-05-23 Lester Ingber

Empirical evidence demonstrates that every region of the neocortex represents information using sparse activity patterns. This paper examines Sparse Distributed Representations (SDRs), the primary information representation strategy in…

Neurons and Cognition · Quantitative Biology 2015-03-26 Subutai Ahmad , Jeff Hawkins

Despite substantial research into the biological basis of memory, the precise mechanisms by which experiences are encoded, stored, and retrieved in the brain remain incompletely understood. A growing body of evidence supports the engram…

Neural and Evolutionary Computing · Computer Science 2025-10-28 Daniel Szelogowski

In the mammalian brain newly acquired memories depend on the hippocampus for maintenance and recall, but over time these functions are taken over by the neocortex through a process called systems consolidation. However, reactivation of a…

Neurons and Cognition · Quantitative Biology 2019-03-29 Peter Helfer , Thomas R. Shultz

In the mammalian brain, newly acquired memories depend on the hippocampus for maintenance and recall, but over time the neocortex takes over these functions, rendering memories hippocampus-independent. The process responsible for this…

Neurons and Cognition · Quantitative Biology 2021-07-02 Peter Helfer , Thomas R. Shultz

Complementary Learning Systems theory holds that intelligent agents need two learning systems. Semantic memory is encoded in the neocortex with dense, overlapping representations and acquires structured knowledge. Episodic memory is encoded…

Machine Learning · Computer Science 2025-09-03 Lucie Fontaine , Frédéric Alexandre

Fueled in part by recent applications in neuroscience, the multivariate Hawkes process has become a popular tool for modeling the network of interactions among high-dimensional point process data. While evaluating the uncertainty of the…

Machine Learning · Statistics 2020-07-16 Xu Wang , Mladen Kolar , Ali Shojaie

Plasticity is one of the most important properties of the nervous system, which enables animals to adjust their behavior to the ever-changing external environment. Changes in synaptic efficacy between neurons constitute one of the major…

Neurons and Cognition · Quantitative Biology 2018-01-23 Taishi Iwasaki , Hideitsu Hino , Masami Tatsuno , Shotaro Akaho , Noboru Murata

Understanding the pathways whereby an intervention has an effect on an outcome is a common scientific goal. A rich body of literature provides various decompositions of the total intervention effect into pathway specific effects.…

Methodology · Statistics 2020-01-20 David Benkeser

Fractionally integrated time series, exhibiting long memory with slowly decaying autocorrelations, are frequently encountered in economics, finance, and related fields. Since the seminal work of Robinson (1995), a variety of semiparametric…

Econometrics · Economics 2025-12-17 Jason R. Blevins

Neuroscience has recently made much progress, expanding the complexity of both neural-activity measurements and brain-computational models. However, we lack robust methods for connecting theory and experiment by evaluating our new big…

Quantitative Methods · Quantitative Biology 2023-07-06 Heiko H. Schütt , Alexander D. Kipnis , Jörn Diedrichsen , Nikolaus Kriegeskorte

Recent studies have reported that T cells can integrate signals between interrupted encounters with Antigen Presenting Cells (APCs) in such a way that the process of signal integration exhibits a form of memory. Here, we carry out a…

Molecular Networks · Quantitative Biology 2007-07-18 Jason W. Locasale

The neocortex, a complex system driving multi-region interactions, remains a core puzzle in neuroscience. Despite quantitative insights across brain scales, understanding the mechanisms underlying neural activities is challenging. Advances…

Neurons and Cognition · Quantitative Biology 2024-11-27 Xiaochen Wang , Yuxuan Wu , Feng Zhang , Jin Wang

This document presents the material of two lectures on statistical physics and neural representations, delivered by one of us (R.M.) at the Fundamental Problems in Statistical Physics XIV summer school in July 2017. In a first part, we…

Data Analysis, Statistics and Probability · Physics 2018-06-13 Simona Cocco , Rémi Monasson , Lorenzo Posani , Sophie Rosay , Jérôme Tubiana
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