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We propose a continuum model for pattern formation, based on the multiphase model framework, to explore in vitro cell patterning within an extracellular matrix. We demonstrate that, within this framework, chemotaxis-driven cell migration…

Cell Behavior · Quantitative Biology 2022-11-21 Georgina Al-Badri , James B. Phillips , Rebecca J. Shipley , Nicholas C. Ovenden

Cell sorting, the segregation of cells with different properties into distinct domains, is a key phenomenon in biological processes such as embryogenesis. We use a phase-field model of a confluent cell layer to study the role of activity in…

Biological Physics · Physics 2024-03-05 James N. Graham , Guanming Zhang , Julia M. Yeomans

The effects of internal adaptation dynamics on the self-organized aggregation of chemotactic bacteria are investigated by Monte Carlo (MC) simulations based on a two-stream kinetic transport equation coupled with a reaction-diffusion…

Analysis of PDEs · Mathematics 2021-10-07 Shugo Yasuda

The rapid adhesion of motile bacteria from dilute suspensions poses a fundamental non-equilibrium problem: hydrodynamic interactions bias bacterial motion near surfaces without generating stable confinement, while electrostatic interactions…

Soft Condensed Matter · Physics 2026-01-13 Dixi Yang , Anheng Wang , Jia Huang , Xiaofeng Zhuo , Chunming Wang , Hajime Tanaka , Jiaxing Yuan

One of the most notable features in repulsive particle based active matter systems is motility-induced-phase separation (MIPS) where a dense, often crystalline phase coexists with a low density fluid. In most active matter studies, the…

Soft Condensed Matter · Physics 2024-04-23 P. Forgacs , A. Libal , C. Reichhardt , N. Hengartner , C. J. O. Reichhardt

Communication and coordination play a major role in the ability of bacterial cells to adapt to ever changing environments and conditions. Recent work has shown that such coordination underlies several aspects of bacterial responses…

Quantitative Methods · Quantitative Biology 2016-04-12 Shashank Singh , Sabrina Rashid , Zhicheng Long , Saket Navlakha , Hanna Salman , Zoltan N. Oltvai , Ziv Bar-Joseph

Stress fibers are contractile actomyosin bundles commonly observed in the cytoskeleton of metazoan cells. The spatial profile of the polarity of actin filaments inside contractile actomyosin bundles is either monotonic (graded) or periodic…

Quantitative Methods · Quantitative Biology 2010-12-09 N. Yoshinaga , J. -F. Joanny , J. Prost , P. Marcq

Monolayers of growing non-motile rod-shaped bacteria act as active nematic materials composed of hard particles rather than the flexible components of other commonly studied active nematics. The organization of these granular monolayers has…

Soft Condensed Matter · Physics 2023-05-12 Blake Langeslay , Gabriel Juarez

A new model that describes adsorption and clustering of particles on a surface is introduced. A {\it clustering} transition is found which separates between a phase of weakly correlated particle distributions and a phase of strongly…

Statistical Mechanics · Physics 2009-10-31 Ofer Biham , Ofer Malcai , Daniel A. Lidar , David Avnir

We propose a multi-patch model of cholera transmission integrating environmental contamination, human mobility, and nutritional vulnerability. The population is stratified by food security status, and transmission occurs via human contact,…

Populations and Evolution · Quantitative Biology 2025-09-09 Jean-Marc Mandeng

We coarse-grain a model of closely-packed ellipses that can vary their aspect ratio to derive continuum equations for materials comprising confluent deformable particles such as epithelial cell layers. We show that contractile nearest…

Soft Condensed Matter · Physics 2025-01-14 Mehrana R. Nejad , Julia M Yeomans

Formation of spatial patterns of cells is a recurring theme in biology and often depends on regulated cell motility. Motility of M. xanthus depends on two motility machineries: the S-engine and A-engine. Moving M. xanthus cells can organize…

A classification of dynamical systems in terms of their variational properties is reviewed. Within this classification, front propagation is discussed in a non-gradient relaxational potential flow. The model is motivated by transient…

patt-sol · Physics 2016-09-08 M. San Miguel , R. Montagne , A. Amengual , E. Hernandez-Garcia

Advances in synthetic biology allow us to engineer bacterial collectives with pre-specified characteristics. However, the behavior of these collectives is difficult to understand, as cellular growth and division as well as extra-cellular…

Cell Behavior · Quantitative Biology 2017-09-13 James J. Winkle , Oleg Igoshin , Matthew R. Bennett , Krešimir Josić , William Ott

Bacteria are ubiquitous in our daily lives, either as motile planktonic cells or as immobilized surface-attached biofilms. These different phenotypic states play key roles in agriculture, environment, industry, and medicine; hence, it is…

Populations and Evolution · Quantitative Biology 2021-12-07 Jenna A. Ott , Selena Chiu , Daniel B. Amchin , Tapomoy Bhattacharjee , Sujit S. Datta

Colonies of rod-shaped bacteria constitute a system of colloidal active matter with nematic properties. As a single initial bacterium multiplies through repeated divisions, the resulting colony quickly loses long-range orientational order,…

Immotile microbes inhabit nearly every environment on Earth, from soils and sediments to food matrices -- yet how they disperse through these physically confining environments is poorly understood. Here, we show that immotile microbial…

Controlling bacterial surface adhesion and subsequent biofilm formation in fluid systems is crucial for the safety and efficacy of medical and industrial processes. Here, we theoretically examine the transport of bacteria close to surfaces,…

Soft Condensed Matter · Physics 2025-07-08 Edwina F. Yeo , Benjamin J. Walker , Philip Pearce , Mohit P. Dalwadi

Pigmentation abnormalities, ranging from hypo- to hyperpigmentation, can serve as biomarkers of developmental disruption in fish exposed to environmental contaminants. However, the mechanistic pathways underlying these alterations remain…

Quantitative Methods · Quantitative Biology 2026-01-21 Pranali Roy Chowdhury , Tian Xu Wang , Abbey MacDonald , Keith B. Tierney , Hao Wang

Biological systems excel at building spatial structures on scales ranging from nanometers to kilometers and exhibit temporal patterning from milliseconds to years. One approach that nature has taken to accomplish this relies on the…

Cell Behavior · Quantitative Biology 2009-11-10 Herbert Levine , Eshel Ben-Jacob