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In this paper we study a nonlinear reaction-diffusion system which models an infectious disease caused by bacteria such as those for cholera. One of the significant features in this model is that a certain portion of the recovered human…

Analysis of PDEs · Mathematics 2022-02-01 Hong-Ming Yin , Jun Zou

Bacteria such as Escherichia coli (E. coli) exhibit biased motion if kept in a spatially non-uniform chemical environment. Here, we bring out unique time-dependent characteristics of bacterial chemotaxis, in response to a diffusing spatial…

Biological Physics · Physics 2018-12-05 Sibendu Samanta , Ritwik Layek , Shantimoy Kar , Sudipta Mukhopadhyay , Suman Chakraborty

For non-motile microorganisms, spatial expansion in quiescent fluids is presumed to be limited by diffusion. We report that microbial colonies can explosively circumvent this constraint through a self-amplifying physical process. As…

Soft Condensed Matter · Physics 2025-12-19 Jimreeves David , Shashi Thutupalli

This is supplementary information for arXiv:1204.4896, which also appeared in Physical Biology 9, 026008 (2012). Main text abstract: Evolutionary experiments with microbes are a powerful tool to study mutations and natural selection. These…

Populations and Evolution · Quantitative Biology 2012-05-01 Kirill S Korolev , Melanie J I Müller , Nilay Karahan , Andrew W Murray , Oskar Hallatschek , David R Nelson

The solution space of genome-scale models of cellular metabolism provides a map between physically viable flux configurations and cellular metabolic phenotypes described, at the most basic level, by the corresponding growth rates. By…

Molecular Networks · Quantitative Biology 2016-05-30 Daniele De Martino , Fabrizio Capuani , Andrea De Martino

Through a combination of experiments and modeling, we have demonstrated a novel pattern formation phenomenon in an isothermal miscible fluid system involving simple protein and sugar solutions. We introduced dye-tagged protein solution into…

Evolutionary experiments with microbes are a powerful tool to study mutations and natural selection. These experiments, however, are often limited to the well-mixed environments of a test tube or a chemostat. Since spatial organization can…

Populations and Evolution · Quantitative Biology 2012-05-02 Kirill S Korolev , Melanie J I Müller , Nilay Karahan , Andrew W Murray , Oskar Hallatschek , David R Nelson

Reaction-diffusion models have been used over decades to study biological systems. In this context, evolution equations for probability distribution functions and the associated stochastic differential equations have nowadays become…

Statistical Mechanics · Physics 2018-10-09 C. Escudero , S. B. Yuste , E. Abad , F. Le Vot

Flagellated bacteria on nutrient-rich substrates can differentiate into a swarming state and move in dense swarms across surfaces. A recent experiment measured the flow in the fluid around an Escherichia coli swarm (Wu, Hosu and Berg, 2011…

Biological Physics · Physics 2016-07-28 Justas Dauparas , Eric Lauga

We study a minimal model of a crawling eukaryotic cell with a chemical polarity controlled by a reaction-diffusion mechanism describing Rho GTPase dynamics. The size, shape, and speed of the cell emerge from the combination of the chemical…

Biological Physics · Physics 2017-01-11 Brian A. Camley , Yanxiang Zhao , Bo Li , Herbert Levine , Wouter-Jan Rappel

Immotile microbes inhabit nearly every environment on Earth, from soils and sediments to food matrices -- yet how they disperse through these physically confining environments is poorly understood. Here, we show that immotile microbial…

While bacterial swimming has been well characterized in uniform liquid environments, only little is known about how bacteria propagate through complex environments, such as gel-like matrices or porous media that are typically encountered in…

Soft Condensed Matter · Physics 2024-08-06 Agniva Datta , Sönke Beier , Veronika Pfeifer , Robert Großmann , Carsten Beta

The diffusion of particles in complex media has gained significant interest due to its dual relevance: probing the viscoelastic properties of materials via microrheology and assessing the extent of particle displacement over time. In this…

Soft Condensed Matter · Physics 2025-06-24 Fabian A. Garcia Daza , Alvaro Rodriguez-Rivas , Fernando Govantes , Alejandro Cuetos

We introduce a three-dimensional stochastic reaction-diffusion model to describe MinD/MinE dynamical structures in Escherichia coli. This model spontaneously generates pole-to-pole oscillations of the membrane-associated MinD proteins, MinE…

Subcellular Processes · Quantitative Biology 2007-05-23 Nenad Pavin , Hana Cipcic Paljetak , Vladimir Krstic

We present a mathematical model of glucose-lactose diauxic growth in Escherichia coli including both the postive and negative regulation mechanisms of the lactose operon as well as the inducer exclusion. To validate this model, we first…

Other Quantitative Biology · Quantitative Biology 2011-01-31 Zhao Lu , Michael A Lee

The enteric bacterium Proteus mirabilis, which is a pathogen that forms biofilms in vivo, can swarm over hard surfaces and form concentric ring patterns in colonies. Colony formation involves two distinct cell types: swarmer cells that…

Populations and Evolution · Quantitative Biology 2015-05-28 Chuan Xue , Elena O. Budrene , Hans G. Othmer

Experiments were performed to test the effect of an electric field on growing E-coli cultures. Cell growing dishes were fitted with platinum wires to create a potential drop across the dish. Water diluted E-coli cultures were brushed across…

Biological Physics · Physics 2017-09-11 Eshel Faraggi

To explore the coupling between a growing population of microorganisms such as E. coli and a nonuniform nutrient distribution, we formulate a minimalistic model. It consists of active Brownian particles that divide and grow at a…

Biological Physics · Physics 2024-01-11 Till Welker , Holger Stark

The bacterium Escherichia coli (E. coli) moves in its natural environment in a series of straight runs, interrupted by tumbles which cause change of direction. It performs chemotaxis towards chemo-attractants by extending the duration of…

Quantitative Methods · Quantitative Biology 2010-07-12 Melissa Reneaux , Manoj Gopalakrishnan

Cells in tissues can organize into a broad spectrum of structures according to their function. Drastic changes of organization, such as epithelial-mesenchymal transitions or the formation of spheroidal aggregates, are often associated…

Biological Physics · Physics 2016-12-22 Bart Smeets , Ricard Alert , Jiri Pesek , Ignacio Pagonabarraga , Herman Ramon , Romaric Vincent