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A central goal in designing clinical trials is to find the test that maximizes power (or equivalently minimizes required sample size) for finding a false null hypothesis subject to the constraint of type I error. When there is more than one…

Methodology · Statistics 2022-09-21 Ruth Heller , Abba Krieger , Saharon Rosset

Consider the multiple testing problem of testing k null hypotheses, where the unknown family of distributions is assumed to satisfy a certain monotonicity assumption. Attention is restricted to procedures that control the familywise error…

Statistics Theory · Mathematics 2007-06-13 E. L. Lehmann , Joseph P. Romano , Juliet Popper Shaffer

The classical binary hypothesis testing problem is revisited. We notice that when one of the hypotheses is composite, there is an inherent difficulty in defining an optimality criterion that is both informative and well-justified. For…

Statistics Theory · Mathematics 2021-03-29 Michael Bell , Yuval Kochman

In this paper, we have established a general framework of multistage hypothesis tests which applies to arbitrarily many mutually exclusive and exhaustive composite hypotheses. Within the new framework, we have constructed specific…

Statistics Theory · Mathematics 2013-11-05 Xinjia Chen

We propose a new approach to sequential testing which is an adaptive (on-line) extension of the (off-line) framework developed in [10]. It relies upon testing of pairs of hypotheses in the case where each hypothesis states that the vector…

Statistics Theory · Mathematics 2017-02-27 Anatoli Juditsky , Arkadi Nemirovski

Multiple testing problems arise naturally in scientific studies because of the need to capture or convey more information with more variables. The literature is enormous, but the emphasis is primarily methodological, providing numerous…

Other Statistics · Statistics 2020-10-07 Yudi Pawitan , Arvid Sjölander

This work deals with a general problem of testing multiple hypotheses about the distribution of a discrete-time stochastic process. Both the Bayesian and the conditional settings are considered. The structure of optimal sequential tests is…

Statistics Theory · Mathematics 2009-12-23 Andrey Novikov

We discuss a general approach to handling "multiple hypotheses" testing in the case when a particular hypothesis states that the vector of parameters identifying the distribution of observations belongs to a convex compact set associated…

Statistics Theory · Mathematics 2016-02-24 A. Goldenshluger , A. Juditski , A. Nemirovski

In certain real-world optimization scenarios, practitioners are not interested in solving multiple problems but rather in finding the best solution to a single, specific problem. When the computational budget is large relative to the cost…

Machine Learning · Computer Science 2026-02-10 Judith Echevarrieta , Etor Arza , Aritz Pérez , Josu Ceberio

We servey a series of investigations of optimal testing of multiple hypotheses conserning various multiobject models. These studies are a bright instance of application of methods and technics developed in Shannon information theory to…

Statistics Theory · Mathematics 2012-04-16 Evgueni Haroutunian , Parandzem Hakobyan

Executing various sequences of system functions in a system under test represents one of the primary techniques in software testing. The natural way to create effective, consistent and efficient test sequences is to model the system under…

Software Engineering · Computer Science 2019-12-05 Miroslav Bures , Bestoun S. Ahmed

The problem of binary hypothesis testing between two probability measures is considered. New sharp bounds are derived for the best achievable error probability of such tests based on independent and identically distributed observations.…

Information Theory · Computer Science 2024-05-30 Valentinian Lungu , Ioannis Kontoyiannis

We typically construct optimal designs based on a single objective function. To better capture the breadth of an experiment's goals, we could instead construct a multiple objective optimal design based on multiple objective functions. While…

Methodology · Statistics 2023-03-09 Lucy L. Gao , Jane J. Ye , Shangzhi Zeng , Julie Zhou

It is quite common in modern research, for a researcher to test many hypotheses. The statistical (frequentist) hypothesis testing framework, does not scale with the number of hypotheses in the sense that naively performing many hypothesis…

Methodology · Statistics 2013-06-26 Jonathan Rosenblatt

Simultaneous estimation of multiple parameters in quantum metrological models is complicated by factors relating to the (i) existence of a single probe state allowing for optimal sensitivity for all parameters of interest, (ii) existence of…

Quantum Physics · Physics 2019-02-01 Sammy Ragy , Marcin Jarzyna , Rafal Demkowicz-Dobrzanski

The problem of multiple hypothesis testing arises when there are more than one hypothesis to be tested simultaneously for statistical significance. This is a very common situation in many data mining applications. For instance, assessing…

Machine Learning · Statistics 2009-06-30 Sami Hanhijärvi , Kai Puolamäki , Gemma C. Garriga

The article discusses the concept of hyperparametric optimization of recommendation algorithms using an integral assessment that combines various performance indicators into a single consolidated criterion. This approach is opposed to…

Machine Learning · Computer Science 2025-08-29 Roman S. Kulshin , Anatoly A. Sidorov

Over time, clinical trials have increasingly incorporated complex design and analysis elements such as interim analyses, adaptations, multiple endpoints, and sophisticated multiplicity schemes for multiple endpoints and/or treatment arms…

The severity of type II errors is frequently ignored when deriving a multiple testing procedure, even though utilizing it properly can greatly help in making correct decisions. This paper puts forward a theory behind developing a multiple…

Methodology · Statistics 2014-03-25 Li He , Sanat K. Sarkar , Zhigen Zhao

Within diagnostic reasoning there have been a number of proposed definitions of a diagnosis, and thus of the most likely diagnosis, including most probable posterior hypothesis, most probable interpretation, most probable covering…

Artificial Intelligence · Computer Science 2013-04-05 David L. Poole , Gregory M. Provan
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