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Dose-finding trials are a key component of the drug development process and rely on a statistical design to help inform dosing decisions. Triallists wishing to choose a design require knowledge of operating characteristics of competing…

Computation · Statistics 2025-03-11 Michael Sweeting , Daniel Slade , Dan Jackson , Kristian Brock

Sequential design is a highly active field of research in active learning which provides a general framework for designing computer experiments with limited computational budgets. It aims to create efficient surrogate models to replace…

Methodology · Statistics 2025-01-03 Paul Lartaud , Philippe Humbert , Josselin Garnier

Stochastic process models are now commonly used to analyse complex biological, ecological and industrial systems. Increasingly there is a need to deliver accurate estimates of model parameters and assess model fit by optimizing the timing…

Computation · Statistics 2018-09-18 Colin S. Gillespie , Richard J. Boys

In characterization of quantum systems, adapting measurement settings based on data while it is collected can generally outperform in efficiency conventional measurements that are carried out independently of data. The existing methods for…

Quantum Physics · Physics 2016-11-21 Markku P. V. Stenberg , Frank K. Wilhelm

We propose a novel platform for the study of quantum phase transitions in one dimension (1D QPT). The system consists of a specially designed chain of asymmetric SQUIDs; each SQUID contains several Josephson junctions with one junction…

Strongly Correlated Electrons · Physics 2018-12-04 M. T. Bell , B. Doucot , M. E. Gershenson , L. B. Ioffe , A. Petkovic

A goal of quantum information technology is to control the quantum state of a system, including its preparation, manipulation, and measurement. However, scalability to many qubits and controlled connectivity between any selected qubits are…

Superconductivity · Physics 2009-11-10 J. Q. You , J. S. Tsai , Franco Nori

We investigate the static properties of 0-$\pi$ Josephson junctions, with particular emphasis on their application in superconducting quantum circuits. Using a theoretical framework based on the sine-Gordon equation, we analyze the phase…

Mesoscale and Nanoscale Physics · Physics 2025-05-20 N. Stefanakis

We propose a model describing the formation of both dual (quantum) and classical Shapiro steps in small Josephson junctions. According to this model, the dual Shapiro steps are formed at relatively low frequency of the microwave signal and…

The optimal selection of experimental conditions is essential to maximizing the value of data for inference and prediction, particularly in situations where experiments are time-consuming and expensive to conduct. We propose a general…

Machine Learning · Statistics 2012-12-04 Xun Huan , Youssef M. Marzouk

History-dependent constitutive models serve as macroscopic closures for the aggregated effects of micromechanics. Their parameters are typically learned from experimental data. With a limited experimental budget, eliciting the full range of…

Materials Science · Physics 2026-04-28 Kaushik Bhattacharya , Lianghao Cao , Andrew Stuart

The extraction of transition frequencies from a spectrum has conventionally relied on empirical methods, and particularly in complex systems, it is a time-consuming and cumbersome process. To address this challenge, we establish a…

Quantum Physics · Physics 2025-07-30 A. Tomonaga , H. Mukai , K. Mizuno , J. S. Tsai

Persistent control of a transmon qubit is performed by a feedback protocol based on continuous heterodyne measurement of its fluorescence. By driving the qubit and cavity with microwave signals whose amplitudes depend linearly on the…

Quantum Physics · Physics 2016-08-09 P. Campagne-Ibarcq , S. Jezouin , N. Cottet , P. Six , L. Bretheau , F. Mallet , A. Sarlette , P. Rouchon , B. Huard

Inferring the causal structure of a system typically requires interventional data, rather than just observational data. Since interventional experiments can be costly, it is preferable to select interventions that yield the maximum amount…

Methodology · Statistics 2021-03-30 Michele Zemplenyi , Jeffrey W. Miller

We study approaches to robust model-based design of experiments in the context of maximum-likelihood estimation. These approaches provide robustification of model-based methodologies for the design of optimal experiments by accounting for…

Methodology · Statistics 2021-09-03 Anwesh Reddy Gottu Mukkula , Michal Mateáš , Miroslav Fikar , Radoslav Paulen

Sequential Multiple-Assignment Randomized Trials (SMARTs) play an increasingly important role in psychological and behavioral health research. This experimental approach enables researchers to answer scientific questions about how to…

Methodology · Statistics 2023-06-21 John J. Dziak , Daniel Almirall , Walter Dempsey , Catherine Stanger , Inbal Nahum-Shani

A genuine feature of projective quantum measurements is that they inevitably alter the mean energy of the observed system if the measured quantity does not commute with the Hamiltonian. Compared to the classical case, Jacobs proved that…

Statistical Mechanics · Physics 2015-06-10 Kay Brandner , Michael Bauer , Michael T. Schmid , Udo Seifert

We observe a series of discontinuities in the above gap current/voltage characteristics of highly transmissive Nb/Si superconductor/semiconductor interfaces. The bias at which each switch occurs decreases in quantized steps as a function of…

Superconductivity · Physics 2009-10-30 M. J. Black , B. W. Alphenaar , H. Ahmed

We performed a novel phase sensitive microwave reflection experiment which directly probes the dynamics of the Josephson plasma resonance in both the linear and non-linear regime. When the junction was driven below the plasma frequency into…

A crucial limit to measurement efficiencies of superconducting circuits comes from losses involved when coupling to an external quantum amplifier. Here, we realize a device circumventing this problem by directly embedding a two-level…

Superconducting digital computing systems, primarily involving Josephson junctions are actively being pursued as high performance and low energy dissipating alternatives to CMOS-based technologies for petascale and exascale computers,…

Applied Physics · Physics 2018-07-04 Uday S. Goteti , Michael C. Hamilton