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We propose to use Bayesian optimization (BO) to improve the efficiency of the design selection process in clinical trials. BO is a method to optimize expensive black-box functions, by using a regression as a surrogate to guide the search.…
Bayesian optimization is a popular black-box optimization method for parameter learning in control and robotics. It typically requires an objective function that reflects the user's optimization goal. However, in practical applications,…
In several combinatorial optimization problems arising in cryptography and design theory, the admissible solutions must often satisfy a balancedness constraint, such as being represented by bitstrings with a fixed number of ones. For this…
Many real-world decision problems require solving, again and again, combinatorial optimization instances drawn from a common distribution. A recent line of structured learning methods exploits this regularity by learning policies that pair…
The structure of data organization is widely recognized as having a substantial influence on the efficacy of machine learning algorithms, particularly in binary classification tasks. Our research provides a theoretical framework suggesting…
Model explainability is crucial for human users to be able to interpret how a proposed classifier assigns labels to data based on its feature values. We study generalized linear models constructed using sets of feature value rules, which…
We consider Online Convex Optimization (OCO) in the setting where the costs are $m$-strongly convex and the online learner pays a switching cost for changing decisions between rounds. We show that the recently proposed Online Balanced…
The problem of constructing optimal discriminating designs for a class of regression models is considered. We investigate a version of the $T_p$-optimality criterion as introduced by Atkinson and Fedorov [Biometrika 62 (1975a) 289-303]. The…
This paper introduces a new class of optimal switching problems, where the player is allowed to switch at a sequence of exogenous Poisson arrival times, and the underlying switching system is governed by an infinite horizon backward…
We consider the problem of optimizing hybrid structures (mixture of discrete and continuous input variables) via expensive black-box function evaluations. This problem arises in many real-world applications. For example, in materials design…
Optimal designs are usually model-dependent and likely to be sub-optimal if the postulated model is not correctly specified. In practice, it is common that a researcher has a list of candidate models at hand and a design has to be found…
Nervous systems, like any organismal structure, have been shaped by evolutionary processes to increase fitness. The resulting neural 'bauplan' has to account for multiple objectives simultaneously, including computational function as well…
Optimal design is a critical yet challenging task within many applications. This challenge arises from the need for extensive trial and error, often done through simulations or running field experiments. Fortunately, sequential optimal…
Unitary $t$-designs are `good' finite subsets of the unitary group $U(d)$ that approximate the whole unitary group $U(d)$ well. Unitary $t$-designs have been applied in randomized benchmarking, tomography, quantum cryptography and many…
We consider a setting in which a principal gets to choose which game from some given set is played by a group of agents. The principal would like to choose a game that favors one of the players, the social preferences of the players, or the…
In this paper we study optimality aspects of a certain type of designs in a multi-way heterogeneity setting. These are ``duals" of plans orthogonal through the block factor (POTB). Here by the dual of a main effect plan (say $\rho$) we mean…
The Bayesian framework is a well-studied and successful framework for inductive reasoning, which includes hypothesis testing and confirmation, parameter estimation, sequence prediction, classification, and regression. But standard…
We prove that the equational theory of the positive calculus of relations with transitive closure (PCoR*) is EXPSPACE-complete. Here, PCoR* terms consist of the following standard operators on binary relations: identity, empty,…
Balanced incomplete block designs (BIBDs) are a class of designs with v treatments and b blocks of size k that are optimal with regards to a wide range of optimality criteria, but it is not clear which designs to choose for combinations of…
Bayesian optimization (BO) is a powerful framework to optimize black-box expensive-to-evaluate functions via sequential interactions. In several important problems (e.g. drug discovery, circuit design, neural architecture search, etc.),…