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"Module networks" are a framework to learn gene regulatory networks from expression data using a probabilistic model in which coregulated genes share the same parameters and conditional distributions. We present a method to infer ensembles…

Quantitative Methods · Quantitative Biology 2009-04-09 Tom Michoel , Riet De Smet , Anagha Joshi , Kathleen Marchal , Yves Van de Peer

The ubiquity of modules in biological networks may result from an evolutionary benefit of a modular organization. For instance, modularity may increase the rate of adaptive evolution, because modules can be easily combined into new…

Molecular Networks · Quantitative Biology 2011-08-26 Areejit Samal , Andreas Wagner , Olivier C. Martin

We consider networks with two types of nodes. The v-nodes, called centers, are hyperconnected and interact one to another via many u-nodes, called satellites. This centralized architecture, widespread in gene networks, realize a bow-tie…

Molecular Networks · Quantitative Biology 2012-03-02 Sergei Vakulenko , Ovidiu Radulescu

Most existing swarm pattern formation methods depend on a predefined gene regulatory network (GRN) structure that requires designers' priori knowledge, which is difficult to adapt to complex and changeable environments. To dynamically adapt…

Neural and Evolutionary Computing · Computer Science 2019-11-04 Zhun Fan , Zhaojun Wang , Xiaomin Zhu , Bingliang Hu , Anmin Zou , Dongwei Bao

Cell fate decisions emerge as a consequence of a complex set of gene regulatory networks. Models of these networks are known to have more parameters than data can determine. Recent work, inspired by Waddington's metaphor of a landscape, has…

Quantitative Methods · Quantitative Biology 2023-05-08 Archishman Raju , Eric D. Siggia

Real-world networks such as the Internet and WWW have many common traits. Until now, hundreds of models were proposed to characterize these traits for understanding the networks. Because different models used very different mechanisms, it…

Social and Information Networks · Computer Science 2014-09-02 Bojin Zheng , Hongrun Wu , Li Kuang , Jun Qin , Wenhua Du , Jianmin Wang , Deyi Li

The study of temporal networks is motivated by the simple and important observation that just as network structure can affect dynamics, so can structure in time. Just as network topology can teach us about the system in question, so can its…

Physics and Society · Physics 2021-03-26 Petter Holme , Jari Saramäki

This study presents the approach to analyzing the evolution of an arbitrary complex system whose behavior is characterized by a set of different time-dependent factors. The key requirement for these factors is only that they must contain an…

Data Analysis, Statistics and Probability · Physics 2020-12-01 Anatolii V. Mokshin , Vladimir V. Mokshin , Diana A. Mirziyarova

Complex networks theory has commonly been used for modelling and understanding the interactions taking place between the elements composing complex systems. More recently, the use of generative models has gained momentum, as they allow…

Physics and Society · Physics 2016-05-19 Massimiliano Zanin , Marco Correia , Pedro A. C. Sousa , Jorge Cruz

Generative mechanisms which lead to empirically observed structure of networked systems from diverse fields like biology, technology and social sciences form a very important part of study of complex networks. The structure of many…

Physics and Society · Physics 2015-12-03 Snehal M. Shekatkar , G. Ambika

The ability to computationally generate novel yet physically foldable protein structures could lead to new biological discoveries and new treatments targeting yet incurable diseases. Despite recent advances in protein structure prediction,…

Biomolecules · Quantitative Biology 2022-11-28 Kevin E. Wu , Kevin K. Yang , Rianne van den Berg , James Y. Zou , Alex X. Lu , Ava P. Amini

The advantages of temporal networks in capturing complex dynamics, such as diffusion and contagion, has led to breakthroughs in real world systems across numerous fields. In the case of human behavior, face-to-face interaction networks…

Social and Information Networks · Computer Science 2025-06-06 Nicolò Alessandro Girardini , Antonio Longa , Gaia Trebucchi , Giulia Cencetti , Andrea Passerini , Bruno Lepri

Random networks are increasingly used to analyse complex transportation networks, such as airline routes, roads and rail networks. So far, this research has been focused on describing the properties of the networks with the help of random…

Physics and Society · Physics 2017-09-19 Jürgen Hackl , Bryan T. Adey

Gene duplication is a fundamental evolutionary mechanism that contributes to biological complexity and diversity (Fortna et al., 2004). Traditionally, research has focused on the duplication of gene sequences (Zhang, 1914). However,…

Molecular Networks · Quantitative Biology 2024-05-07 Ashley Scruse , Jonathan Arnold , Robert Robinson

Network generators that capture the Internet's large-scale topology are crucial for the development of efficient routing protocols and modeling Internet traffic. Our ability to design realistic generators is limited by the incomplete…

Statistical Mechanics · Physics 2009-11-07 Soon-Hyung Yook , Hawoong Jeong , Albert-Laszlo Barabasi

Neural networks leverage robust internal representations in order to generalise. Learning them is difficult, and often requires a large training set that covers the data distribution densely. We study a common setting where our task is not…

Generative diffusion models showed high success in many fields with a powerful theoretical background. They convert the data distribution to noise and remove the noise back to obtain a similar distribution. Many existing reviews focused on…

Machine Learning · Computer Science 2024-09-19 Melike Nur Yeğin , Mehmet Fatih Amasyalı

Naturally occurring networks exhibit quantitative features revealing underlying growth mechanisms. Numerous network mechanisms have recently been proposed to reproduce specific properties such as degree distributions or clustering…

Quantitative Methods · Quantitative Biology 2009-11-10 Manuel Middendorf , Etay Ziv , Chris Wiggins

The number of fixed mutations accumulated in an evolving population often displays a variance that is significantly larger than the mean (the overdispersed molecular clock). By examining a generic evolutionary process on a neutral network…

Populations and Evolution · Quantitative Biology 2009-11-13 Alpan Raval

Our recent paper [Grauwin et al. Sci. Rep. 7 (2017)] demonstrates that community and hierarchical structure of the networks of human interactions largely determines the least and should be taken into account while modeling them. In the…

Social and Information Networks · Computer Science 2017-12-18 Stanislav Sobolevsky
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