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We consider the problem of detecting sparse heterogeneous mixtures in a two-sample setting from a nonparametric perspective, where the effect manifests itself as a positive shift. We suggest a two-sample higher criticism test, and show that…

Statistics Theory · Mathematics 2020-11-30 Rong Huang

In a bivariate setting, we consider the problem of detecting a sparse contamination or mixture component, where the effect manifests itself as a positive dependence between the variables, which are otherwise independent in the main…

Statistics Theory · Mathematics 2020-01-13 Ery Arias-Castro , Rong Huang , Nicolas Verzelen

Higher criticism is a method for detecting signals that are both sparse and weak. Although first proposed in cases where the noise variables are independent, higher criticism also has reasonable performance in settings where those variables…

Statistics Theory · Mathematics 2010-10-05 Peter Hall , Jiashun Jin

We consider two alternative tests to the Higher Criticism test of Donoho and Jin [Ann. Statist. 32 (2004) 962-994] for high-dimensional means under the sparsity of the nonzero means for sub-Gaussian distributed data with unknown column-wise…

Statistics Theory · Mathematics 2013-12-19 Ping-Shou Zhong , Song Xi Chen , Minya Xu

Large-scale multiple testing problems require the simultaneous assessment of many p-values. This paper compares several methods to assess the evidence in multiple binomial counts of p-values: the maximum of the binomial counts after…

Methodology · Statistics 2014-02-26 Guenther Walther

We study the signal detection problem in high dimensional noise data (possibly) containing rare and weak signals. Log-likelihood ratio (LLR) tests depend on unknown parameters, but they are needed to judge the quality of detection tests…

Statistics Theory · Mathematics 2018-08-08 Marc Ditzhaus , Arnold Janssen

In modern high-throughput data analysis, researchers perform a large number of statistical tests, expecting to find perhaps a small fraction of significant effects against a predominantly null background. Higher Criticism (HC) was…

Statistics Theory · Mathematics 2015-04-13 David Donoho , Jiashun Jin

Donoho and Kipnis (2022) showed that the the higher criticism (HC) test statistic has a non-Gaussian phase transition but remarked that it is probably not optimal, in the detection of sparse differences between two large frequency tables…

Statistics Theory · Mathematics 2023-11-08 Hock Peng Chan

This paper compares the higher criticism statistic (Donoho and Jin [Ann. Statist. 32 (2004) 962-994]), a modification of the higher criticism statistic also suggested by Donoho and Jin, and two statistics of the Berk-Jones [Z. Wahrsch.…

Statistics Theory · Mathematics 2015-06-04 Jian Li , David Siegmund

Consider a multiple hypothesis testing setting involving rare/weak effects: relatively few tests, out of possibly many, deviate from their null hypothesis behavior. Summarizing the significance of each test by a P-value, we construct a…

Statistics Theory · Mathematics 2021-10-20 David L. Donoho , Alon Kipnis

We consider the problem of detecting sparse heterogeneous mixtures from a nonparametric perspective, and develop distribution-free tests when all effects have the same sign. Specifically, we assume that the null distribution is symmetric…

Statistics Theory · Mathematics 2013-11-18 Ery Arias-Castro , Meng Wang

A fundamental problem in high-dimensional testing is that of global null testing: testing whether the null holds simultaneously in all of $n$ hypotheses. The max test, which uses the smallest of the $n$ marginal p-values as its test…

Statistics Theory · Mathematics 2020-06-24 Xiao Li , William Fithian

We adapt Higher Criticism (HC) to the comparison of two frequency tables which may -- or may not -- exhibit moderate differences between the tables in some unknown, relatively small subset out of a large number of categories. Our analysis…

Statistics Theory · Mathematics 2023-08-29 David L. Donoho , Alon Kipnis

We consider the problem of detecting a sparse mixture as studied by Ingster (1997) and Donoho and Jin (2004). We consider a wide array of base distributions. In particular, we study the situation when the base distribution has polynomial…

Statistics Theory · Mathematics 2018-02-27 Ery Arias-Castro , Andrew Ying

In the presence of weak overall correlation, it may be useful to investigate if the correlation is significantly and substantially more pronounced over a subpopulation. Two different testing procedures are compared. Both are based on the…

Machine Learning · Statistics 2015-04-22 Stephen Bamattre , Rex Hu , Joseph S. Verducci

For high dimensional statistical models, researchers have begun to focus on situations which can be described as having relatively few moderately large coefficients. Such situations lead to some very subtle statistical problems. In…

Statistics Theory · Mathematics 2009-09-29 T. Tony Cai , Jiashun Jin , Mark G. Low

The problem of signal detection using sparse, faint information is closely related to a variety of contemporary statistical problems, including the control of false-discovery rate, and classification using very high-dimensional data. Each…

Statistics Theory · Mathematics 2008-12-18 Peter Hall , Jiashun Jin

There is a well-known problem in Null Hypothesis Significance Testing: many statistically significant results fail to replicate in subsequent experiments. We show that this problem arises because standard `point-form null' significance…

Methodology · Statistics 2025-02-06 Fintan Costello , Paul Watts

Large-scale simultaneous hypothesis testing appears in many areas such as microarray studies, genome-wide association studies, brain imaging, disease mapping and astronomical surveys. A well-known inference method is to control the false…

Methodology · Statistics 2025-07-22 Xiaoqing Niu , Pengfei Li , Yuejiao Fu

Higher criticism is a large-scale testing procedure that can attain the optimal detection boundary for sparse and faint signals. However, there has been a lack of knowledge in most existing works about its asymptotic distribution for more…

Statistics Theory · Mathematics 2025-11-11 Jingkun Qiu
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