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We address a common problem in large-scale data analysis, and especially the field of genetics, the huge-scale testing problem, where millions to billions of hypotheses are tested together creating a computational challenge to perform…

Methodology · Statistics 2015-01-22 Vered Madar , Sandra Batista

Differentially private multiple testing procedures can protect the information of individuals used in hypothesis tests while guaranteeing a small fraction of false discoveries. In this paper, we propose a differentially private adaptive FDR…

Machine Learning · Statistics 2023-06-01 Xintao Xia , Zhanrui Cai

A systematic multiple hypothesis testing approach is applied to the search for astrophysical sources of high energy neutrinos. The method is based on the maximisation of the detection power maintaining the control of the confidence level of…

Instrumentation and Methods for Astrophysics · Physics 2010-11-24 Bruny Baret , Mathieu Labare , Daniel Bertrand

The generalized linear models (GLM) have been widely used in practice to model non-Gaussian response variables. When the number of explanatory features is relatively large, scientific researchers are of interest to perform controlled…

Methodology · Statistics 2020-07-03 Chenguang Dai , Buyu Lin , Xin Xing , Jun S. Liu

In multiple hypotheses testing it has become widely popular to make inference on the true discovery proportion (TDP) of a set $\mathcal{M}$ of null hypotheses. This approach is useful for several application fields, such as neuroimaging and…

Methodology · Statistics 2023-10-13 Friederike Preusse , Anna Vesely , Thorsten Dickhaus

Multiple hypothesis testing has been widely applied to problems dealing with high-dimensional data, e.g., selecting significant variables and controlling the selection error rate. The most prevailing measure of error rate used in the…

Methodology · Statistics 2022-06-07 Xiaoya Sun , Yan Fu

There has been recent interest in extending the ideas of False Discovery Rates (FDR) to variable selection in regression settings. Traditionally the FDR in these settings has been defined in terms of the coefficients of the full regression…

Methodology · Statistics 2013-02-12 Max Grazier G'Sell , Trevor Hastie , Robert Tibshirani

False discovery rates (FDR) are typically estimated from a mixture of a null and an alternative distribution. Here, we study a complementary approach proposed by Rice and Spiegelhalter (2008) that uses as primary quantities the null model…

Methodology · Statistics 2011-08-03 Bernd Klaus , Korbinian Strimmer

We propose sufficient conditions and computationally efficient procedures for false discovery rate control in multiple testing when the $p$-values are related by a known \emph{dependency graph} -- meaning that we assume independence of…

Methodology · Statistics 2025-07-01 Drew T. Nguyen , William Fithian

In the context of multiple hypotheses testing, the proportion $\pi_0$ of true null hypotheses in the pool of hypotheses to test often plays a crucial role, although it is generally unknown a priori. A testing procedure using an implicit or…

Statistics Theory · Mathematics 2009-02-17 Gilles Blanchard , Etienne Roquain

Some effort has been undertaken over the last decade to provide conditions for the control of the false discovery rate by the linear step-up procedure (LSU) for testing $n$ hypotheses when test statistics are dependent. In this paper we…

Statistics Theory · Mathematics 2007-10-18 Helmut Finner , Thorsten Dickhaus , Markus Roters

We consider controlling the false discovery rate for testing many time series with an unknown cross-sectional correlation structure. Given a large number of hypotheses, false and missing discoveries can plague an analysis. While many…

Methodology · Statistics 2021-06-10 Junpei Komiyama , Masaya Abe , Kei Nakagawa , Kenichiro McAlinn

Sorted L-One Penalized Estimation (SLOPE) has shown the nice theoretical property as well as empirical behavior recently on the false discovery rate (FDR) control of high-dimensional feature selection by adaptively imposing the…

Statistics Theory · Mathematics 2023-02-22 Jingxuan Liang , Hong Chen , Xuelin Zhang , Weifu Li , Xin Tang

When multiple hypotheses are tested, interest is often in ensuring that the proportion of false discoveries (FDP) is small with high confidence. In this paper, confidence upper bounds for the FDP are constructed, which are simultaneous over…

Methodology · Statistics 2020-01-07 Jesse Hemerik , Aldo Solari , Jelle J. Goeman

Variable selection has been widely used in data analysis for the past decades, and it becomes increasingly important in the Big Data era as there are usually hundreds of variables available in a dataset. To enhance interpretability of a…

Methodology · Statistics 2020-08-17 Yuxiang Xie , Kwun Chuen Gary Chan

Testing for differences in features between clusters in various applications often leads to inflated false positives when practitioners use the same dataset to identify clusters and then test features, an issue commonly known as ``double…

Methodology · Statistics 2024-10-10 Lijun Wang , Yingxin Lin , Hongyu Zhao

The topological gap protocol (TGP) is a statistical test designed to identify a topological phase with high confidence and without human bias. It is used to determine a promising parameter regime for operating topological qubits. The…

Mesoscale and Nanoscale Physics · Physics 2025-04-21 Morteza Aghaee , Zulfi Alam , Mariusz Andrzejczuk , Andrey E. Antipov , Mikhail Astafev , Amin Barzegar , Bela Bauer , Jonathan Becker , Umesh Kumar Bhaskar , Alex Bocharov , Srini Boddapati , David Bohn , Jouri Bommer , Leo Bourdet , Samuel Boutin , Benjamin J. Chapman , Sohail Chatoor , Anna Wulff Christensen , Patrick Codd , William S. Cole , Paul Cooper , Fabiano Corsetti , Ajuan Cui , Andreas Ekefjärd , Saeed Fallahi , Luca Galletti , Geoff Gardner , Deshan Govender , Flavio Griggio , Ruben Grigoryan , Sebastian Grijalva , Sergei Gronin , Jan Gukelberger , Marzie Hamdast , Esben Bork Hansen , Sebastian Heedt , Samantha Ho , Laurens Holgaard , Kevin Van Hoogdalem , Jinnapat Indrapiromkul , Henrik Ingerslev , Lovro Ivancevic , Thomas Jensen , Jaspreet Jhoja , Jeffrey Jones , Konstantin V. Kalashnikov , Ray Kallaher , Rachpon Kalra , Farhad Karimi , Torsten Karzig , Maren Elisabeth Kloster , Christina Knapp , Jonne Koski , Pasi Kostamo , Tom Laeven , Gijs de Lange , Thorvald Larsen , Jason Lee , Kyunghoon Lee , Grant Leum , Kongyi Li , Tyler Lindemann , Matthew Looij , Marijn Lucas , Roman Lutchyn , Morten Hannibal Madsen , Nash Madulid , Michael Manfra , Signe Brynold Markussen , Esteban Martinez , Marco Mattila , Robert McNeil , Ryan V. Mishmash , Gopakumar Mohandas , Christian Mollgaard , Michiel de Moor , Trevor Morgan , George Moussa , Chetan Nayak , William Hvidtfelt Padkær Nielsen , Jens Hedegaard Nielsen , Mike Nystrom , Eoin O'Farrell , Keita Otani , Karl Petersson , Luca Petit , Dima Pikulin , Mohana Rajpalke , Alejandro Alcaraz Ramirez , Katrine Rasmussen , David Razmadze , Yuan Ren , Ken Reneris , Ivan A. Sadovskyy , Lauri Sainiemi , Juan Carlos Estrada Saldaña , Irene Sanlorenzo , Emma Schmidgall , Cristina Sfiligoj , Sarat Sinha , Thomas Soerensen , Patrick Sohr , Tomaš Stankevič , Lieuwe Stek , Eric Stuppard , Henri Suominen , Judith Suter , Sam Teicher , Nivetha Thiyagarajah , Raj Tholapi , Mason Thomas , Emily Toomey , Josh Tracy , Michelle Turley , Shivendra Upadhyay , Ivan Urban , Dmitrii V. Viazmitinov , Dominik Vogel , John Watson , Alex Webster , Joseph Weston , Georg W. Winkler , David J. Van Woerkom , Brian Paquelet Wütz , Chung Kai Yang , Emrah Yucelen , Jesús Herranz Zamorano , Roland Zeisel , Guoji Zheng , Justin Zilke

Genomics biobanks are information treasure troves with thousands of phenotypes (e.g., diseases, traits) and millions of single nucleotide polymorphisms (SNPs). The development of methodologies that provide reproducible discoveries is…

Methodology · Statistics 2024-10-08 Jasin Machkour , Michael Muma , Daniel P. Palomar

Multiple hypothesis testing often involves composite nulls, i.e., nulls that are associated with two or more distributions. In many cases, it is reasonable to assume that there is a prior distribution on the distributions despite it is…

Statistics Theory · Mathematics 2008-07-31 Zhiyi Chi

We develop the distribution of the number of hypotheses found to be statistically significant using the rule from Benjamini and Hochberg (1995) for controlling the false discovery rate (FDR). This distribution has both a small sample form…

Methodology · Statistics 2018-02-27 Chang Yu , Daniel Zelterman