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We present a novel approach for generating minority samples that live on low-density regions of a data manifold. Our framework is built upon diffusion models, leveraging the principle of guided sampling that incorporates an arbitrary…

Computer Vision and Pattern Recognition · Computer Science 2024-07-17 Soobin Um , Jong Chul Ye

Diffusion theory is a central tool of modern population genetics, yielding simple expressions for fixation probabilities and other quantities that are not easily derived from the underlying Wright-Fisher model. Unfortunately, the textbook…

Populations and Evolution · Quantitative Biology 2022-12-19 Camila Bräutigam , Matteo Smerlak

Genome-wide patterns of genetic divergence reveal mechanisms of adaptation under gene flow. Empirical data show that divergence is mostly concentrated in narrow genomic regions. This pattern may arise because differentiated loci protect…

Populations and Evolution · Quantitative Biology 2017-02-21 M. Rafajlovic , A. Emanuelsson , K. Johannesson , R. K. Butlin , B. Mehlig

We consider the Moran model in continuous time with two types, mutation, and selection. We concentrate on the ancestral line and its stationary type distribution. Building on work by Fearnhead (J. Appl. Prob. 39 (2002), 38-54) and Taylor…

Populations and Evolution · Quantitative Biology 2013-12-09 Sandra Kluth , Thiemo Hustedt , Ellen Baake

Sweepstakes reproduction refers to a highly skewed individual recruitment success without involving natural selection and may apply to individuals in broadcast spawning populations characterised by Type III survivorship. We consider an…

Populations and Evolution · Quantitative Biology 2026-01-14 Jonathan A Chetwynd-Diggle , Bjarki Eldon

Population genetics theory has laid the foundations for genomics analyses including the recent burst in genome scans for selection and statistical inference of past demographic events in many prokaryote, animal and plant species.…

Populations and Evolution · Quantitative Biology 2014-01-22 Aurelien Tellier , Christophe Lemaire

We derive exact formulae for the allele frequency spectrum under the coalescent with mutation, conditioned on allele counts at some fixed time in the past. We consider unlinked biallelic markers mutating according to a finite sites, or…

Populations and Evolution · Quantitative Biology 2011-09-19 David Bryant , Arindam RoyChoudhury , Remco Bouckaert , Joseph Felsenstein , Noah Rosenberg

Study sample sizes in human genetics are growing rapidly, and in due course it will become routine to analyze samples with hundreds of thousands if not millions of individuals. In addition to posing computational challenges, such large…

Populations and Evolution · Quantitative Biology 2015-06-24 Anand Bhaskar , Andrew G. Clark , Yun S. Song

The purpose of this work is to describe a duality between a fragmentation associated to certain Dirichlet distributions and a natural random coagulation. The dual fragmentation and coalescent chains arising in this setting appear in the…

Probability · Mathematics 2007-05-23 Jean Bertoin , Christina Goldschmidt

Comparing allele frequencies among populations that differ in environment has long been a tool for detecting loci involved in local adaptation. However, such analyses are complicated by an imperfect knowledge of population allele…

Populations and Evolution · Quantitative Biology 2012-09-17 Torsten Günther , Graham Coop

We are interested in the long-time behavior of a diploid population with sexual reproduction, characterized by its genotype composition at one bi-allelic locus. The population is modeled by a 3-dimensional birth-and-death process with…

Probability · Mathematics 2013-09-16 Camille Coron

We review the statistical properties of the genealogies of a few models of evolution. In the asexual case, selection leads to coalescence times which grow logarithmically with the size of the population in contrast with the linear growth of…

Populations and Evolution · Quantitative Biology 2015-06-04 Éric Brunet , Bernard Derrida

Kingman's model describes the evolution of a one-locus haploid population of infinite size and discrete generations under the competition of selection and mutation. A random generalisation has been made in a previous paper which assumes all…

Probability · Mathematics 2020-12-01 Linglong Yuan

Deep generative models produce data according to a learned representation, e.g. diffusion models, through a process of approximation computing possible samples. Approximation can be understood as reconstruction and the large datasets used…

Human-Computer Interaction · Computer Science 2023-09-25 Luís Arandas , Mick Grierson , Miguel Carvalhais

We consider a Moran model with recombination in a haploid population of size $N$. At each birth event, with probability $1-\rho_N R$ the offspring copies one parent's chromosome, and with probability $\rho_N R$ she inherits a chromosome…

Probability · Mathematics 2022-01-19 Amaury Lambert , Verónica Miró Pina , Emmanuel Schertzer

Diffusion has been widely used to describe a random walk of particles or waves, and it requires only one parameter -- the diffusion constant. For waves, however, diffusion is an approximation that disregards the possibility of interference.…

Optics · Physics 2014-01-23 Alexey G. Yamilov , Raktim Sarma , Brandon Redding , Ben Payne , Heeso Noh , Hui Cao

The Yule model and the coalescent model are two neutral stochastic models for generating trees in phylogenetics and population genetics, respectively. Although these models are quite different, they lead to identical distributions…

Populations and Evolution · Quantitative Biology 2015-03-17 Sha Zhu , James H. Degnan , Mike Steel

Understanding the statistical properties of a collection of individuals subject to random displacements and birth-and-death events is key to several applications in physics and life sciences, encompassing the diagnostic of nuclear reactors…

Statistical Mechanics · Physics 2022-06-22 Théophile Bonnet , Davide Mancusi , Andrea Zoia

We consider an extension of the noisy $N$-Branching Random Walk that models the evolution of a population subject to natural selection. We show the existence of a critical value for the noise which separates the limiting genealogical…

Populations and Evolution · Quantitative Biology 2025-03-17 Emmanuel Schertzer , Alejandro H. Wences

Having a precise knowledge of the dispersal ability of a population in a heterogeneous environment is of critical importance in agroecology and conservation biology as it can provide management tools to limit the effects of pests or to…

Populations and Evolution · Quantitative Biology 2015-03-19 L. Roques , E. Walker , P. Franck , S. Soubeyrand , E. K. Klein