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The Computational Singular Perturbation (CSP) method of Lam and Goussis is an iterative method to reduce the dimensionality of systems of ordinary differential equations with multiple time scales. In [J. Nonlin. Sci., to appear], the…

Dynamical Systems · Mathematics 2016-09-07 Antonios Zagaris , Hans G. Kaper , Tasso J. Kaper

The computational singular perturbation (CSP) method is an algorithm which iteratively approximates slow manifolds and fast fibers in multiple-timescale dynamical systems. Since its inception due to Lam and Goussis, the convergence of the…

Dynamical Systems · Mathematics 2019-06-17 Ian Lizarraga , Martin Wechselberger

This article concerns two methods for reducing large systems of chemical kinetics equations, namely, the method of intrinsic low-dimensional manifolds (ILDMs) due to Maas and Pope and an iterative method due to Fraser and further developed…

Dynamical Systems · Mathematics 2009-11-07 Hans G. Kaper , Tasso J. Kaper

The adoption of detailed mechanisms for chemical kinetics often poses two types of severe challenges: First, the number of degrees of freedom is large; and second, the dynamics is characterized by widely disparate time scales. As a result,…

Dynamical Systems · Mathematics 2025-10-01 Eliodoro Chiavazzo , C. William Gear , Carmeline J. Dsilva , Neta Rabin , Ioannis G. Kevrekidis

In dissipative ordinary differential equation systems different time scales cause anisotropic phase volume contraction along solution trajectories. Model reduction methods exploit this for simplifying chemical kinetics via a time scale…

Dynamical Systems · Mathematics 2011-01-13 Dirk Lebiedz , Volkmar Reinhardt , Jochen Siehr

The chemical master equation (CME) is frequently used in systems biology to quantify the effects of stochastic fluctuations that arise due to biomolecular species with low copy numbers. The CME is a system of ordinary differential equations…

Quantitative Methods · Quantitative Biology 2017-10-25 Ankit Gupta , Jan Mikelson , Mustafa Khammash

In this paper, we develop a stochastic Asymptotic-Preserving (sAP) scheme for the kinetic chemotaxis system with random inputs, which will converge to the modified Keller-Segel model with random inputs in the diffusive regime. Based on the…

Numerical Analysis · Mathematics 2017-10-17 Shi Jin , Hanqing Lu , Lorenzo Pareschi

We propose a new class of asymptotic preserving schemes to solve kinetic equations with mono-kinetic singular limit. The main idea to deal with the singularity is to transform the equations by appropriate scalings in velocity. In…

Numerical Analysis · Mathematics 2017-06-30 Alina Chertock , Changhui Tan , Bokai Yan

We propose a stochastic conditional gradient method (CGM) for minimizing convex finite-sum objectives formed as a sum of smooth and non-smooth terms. Existing CGM variants for this template either suffer from slow convergence rates, or…

Machine Learning · Computer Science 2022-04-19 Gideon Dresdner , Maria-Luiza Vladarean , Gunnar Rätsch , Francesco Locatello , Volkan Cevher , Alp Yurtsever

Gradient compression is of growing interests for solving constrained optimization problems including compressed sensing, noisy recovery and matrix completion under limited communication resources and storage costs. Convergence analysis of…

Optimization and Control · Mathematics 2024-10-30 Zhaoyue Xia , Jun Du , Chunxiao Jiang , H. Vincent Poor , Yong Ren

The paper has two goals: It presents basic ideas, notions, and methods for reduction of reaction kinetics models: quasi-steady-state, quasi-equilibrium, slow invariant manifolds, and limiting steps. It describes briefly the current state of…

Chemical Physics · Physics 2022-05-17 A. N. Gorban

We propose the coarse-grained spectral projection method (CGSP), a deep learning-assisted approach for tackling quantum unitary dynamic problems with an emphasis on quench dynamics. We show CGSP can extract spectral components of many-body…

Quantum Physics · Physics 2021-02-03 Pinchen Xie , Weinan E

Efficient analysis and simulation of multiscale stochastic systems of chemical kinetics is an ongoing area for research, and is the source of many theoretical and computational challenges. In this paper, we present a significant improvement…

Numerical Analysis · Mathematics 2016-09-21 Simon Cotter

A hierarchical (triple scale) simulation methodology is presented for the prediction of the dynamical and rheological properties of high molecular weight entangled polymer melts. The methodology consists of atomistic, moderately…

In this paper, we review the construction of low-dimensional manifolds of reduced description for equations of chemical kinetics from the standpoint of the method of invariant manifold (MIM). MIM is based on a formulation of the condition…

Statistical Mechanics · Physics 2007-05-23 Alexander N. Gorban , Iliya V. Karlin

We develop the novel machinery of smooth approximations, and apply it to confirm the CSP dichotomy conjecture for first-order reducts of the random tournament, various homogeneous graphs including the random graph, and for expansions of the…

Logic in Computer Science · Computer Science 2021-06-08 Antoine Mottet , Michael Pinsker

Enzyme kinetics has historically been described by deterministic models, with the Michaelis-Menten (MM) equation serving as a paradigm. However, recent experimental and theoretical advances have made it clear that stochastic fluctuations,…

Molecular Networks · Quantitative Biology 2025-04-08 Jiaji Qu , Malini Rajbhandari

In this paper an approach for decreasing the computational effort required for the split-step Fourier method (SSFM) is introduced. It is shown that using the sparsity property of the simulated signals, the compressive sampling algorithm can…

Computational Physics · Physics 2015-12-15 Cihan Bayindir

We present a microscopic approach to quantum dissipation and sketch the derivation of the kinetic equation describing the evolution of a simple quantum system in interaction with a complex quantum system. A typical quantum complex system is…

Quantum Physics · Physics 2009-10-31 Aurel Bulgac , Giu Do Dand , Dimitri Kusnezov

Singularly perturbed systems (SPSs) are prevalent in engineering applications, where numerically solving their initial value problems (IVPs) is challenging due to stiffness arising from multiple time scales. Classical explicit methods…

Numerical Analysis · Mathematics 2025-04-15 Yibo Shi , Cristian R. Rojas
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