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Motility is an essential factor for an organism's survival and diversification. With the advent of novel single-cell technologies, analytical frameworks and theoretical methods, we can begin to probe the complex lives of microscopic motile…

The circuit-theoretic origins of maximal monotonicity are revisited using modern optimization algorithms for maximal monotone operators. We present an algorithm for computing the periodic behavior of an interconnection of maximal monotone…

Systems and Control · Electrical Eng. & Systems 2021-04-07 Thomas Chaffey , Rodolphe Sepulchre

A monotone self-mapping of the nonnegative orthant induces a monotone discrete-time dynamical system which evolves on the same orthant. If with respect to this system the origin is attractive then there must exists points whose image under…

Numerical Analysis · Mathematics 2010-05-06 Björn S. Rüffer , Fabian R. Wirth

Robust control design is mainly devoted to guarantee closed-loop stability of a model-based control law in presence of parametric and structural uncertainties. The control law is usually a complex feedback law which is derived from a…

Systems and Control · Computer Science 2011-08-12 Enrico Canuto , Wilber Acuna-Bravo , Andrés Molano-Jimenez , José Ospina , Carlos Perez-Montenegro

Living organisms rely on endogenous feedback mechanisms to maintain homeostasis in the presence of uncertainty and environmental fluctuations. An emerging challenge at the interface of control systems engineering and synthetic biology is…

Systems and Control · Electrical Eng. & Systems 2026-02-24 Mario di Bernardo

Robust stability and stochastic stability have separately seen intense study in control theory for many decades. In this work we establish relations between these properties for discrete-time systems and employ them for robust control…

Dynamical Systems · Mathematics 2020-04-20 Benjamin Gravell , Peyman Mohajerin Esfahani , Tyler Summers

When designing autonomous systems, we need to consider multiple trade-offs at various abstraction levels, and the choices of single (hardware and software) components need to be studied jointly. In this work we consider the problem of…

Systems and Control · Electrical Eng. & Systems 2022-09-21 Gioele Zardini , Zelio Suter , Andrea Censi , Emilio Frazzoli

This paper summarizes a research program to express the organization of sensorimotor control by specifying physiological states and the conditions for transitions among them. By a slight change in standard notation, conditional dynamics…

Biological Physics · Physics 2007-05-23 Gin McCollum

In many classification tasks there is a requirement of monotonicity. Concretely, if all else remains constant, increasing (resp. decreasing) the value of one or more features must not decrease (resp. increase) the value of the prediction.…

Machine Learning · Computer Science 2021-06-02 Joao Marques-Silva , Thomas Gerspacher , Martin Cooper , Alexey Ignatiev , Nina Narodytska

Synthetic biology is a recent area of biological engineering, whose aim is to provide cells with novel functionalities. A number of important results regarding the development of control circuits in synthetic biology have been achieved…

Systems and Control · Electrical Eng. & Systems 2024-11-11 Antón Pardo , Sandra Díaz Seoane , Dorin A. Ionescu , Antonis Papachristodoulou , Alejandro F. Villaverde

Symbolic models are abstract descriptions of continuous systems in which symbols represent aggregates of continuous states. In the last few years there has been a growing interest in the use of symbolic models as a tool for mitigating…

Optimization and Control · Mathematics 2007-07-31 Giordano Pola , Paulo Tabuada

Piecewise smooth hybrid systems, involving continuous and discrete variables, are suitable models for describing the multiscale regulatory machinery of the biological cells. In hybrid models, the discrete variables can switch on and off…

Computational Engineering, Finance, and Science · Computer Science 2012-08-21 Vincent Noel , Dima Grigoriev , Sergei Vakulenko , Ovidiu Radulescu

A recent approach to the control of underactuated systems is to look for control laws which will induce some specified structure on the closed loop system. This basic idea is used in several papers already. In this paper, we will describe…

Optimization and Control · Mathematics 2007-05-23 Fedor Andreev , David Auckly , Lev Kapitanski , Shekhar Gosavi , Atul Kelkar , Warren White

In this paper we present a method for designing a linear time invariant (LTI) state-feedback controller to monotonically track a constant step reference at any desired rate of convergence for any arbitrarily assigned initial condition.…

Optimization and Control · Mathematics 2014-02-24 Lorenzo Ntogramatzidis , Jean-Francois Tregouet , Robert Schmid

Stylized models of the neurodynamics that underpin sensory motor control in animals are proposed and studied. The voluntary motions of animals are typically initiated by high level intentions created in the primary cortex through a…

Systems and Control · Electrical Eng. & Systems 2021-10-12 John Baillieul , Zexin Sun

This paper studies the controllability of networked multi-input-multi-output (MIMO) systems, in which the network topology is weighted and directed, and the nodes are heterogeneous higher-dimensional linear time-invariant (LTI) dynamical…

Optimization and Control · Mathematics 2020-06-23 Linying Xiang , Peiru Wang , Fei Chen , Guanrong Chen

Examining individual components of cellular systems has been successful in uncovering molecular reactions and interactions. However, the challenge lies in integrating these components into a comprehensive system-scale map. This difficulty…

Other Quantitative Biology · Quantitative Biology 2024-07-03 Nima Dehghani

In this work, we present a problem of simultaneous input-output feedback linearization and decoupling (non-interacting) for mechanical control systems with outputs. We show that the natural requirement of preserving mechanical structure of…

Optimization and Control · Mathematics 2024-06-25 Marcin Nowicki , Witold Respondek

Robust control theory studies the effect of noise, disturbances, and other uncertainty on system performance. Despite growing recognition across science and engineering that robustness and efficiency tradeoffs dominate the evolution and…

Optimization and Control · Mathematics 2016-06-14 Yoke Peng Leong , John C. Doyle

This note is addressed to giving a short introduction to control theory of stochastic systems, governed by stochastic differential equations in both finite and infinite dimensions. We will mainly explain the new phenomenon and difficulties…

Optimization and Control · Mathematics 2016-12-09 Qi Lu , Xu Zhang
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