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DNA data storage systems encode digital data into DNA strands, enabling dense and durable storage. Efficient data retrieval depends on coverage depth, a key performance metric. We study the random access coverage depth problem and focus on…

Information Theory · Computer Science 2025-07-29 Şeyma Bodur , Stefano Lia , Hiram H. López , Rati Ludhani , Alberto Ravagnani , Lisa Seccia

We present a theoretical as well as experimental investigation of a population of self-replicating segments of code subject to random mutation and survival of the fittest. Under the assumption that such a system constitutes a minimal system…

adap-org · Physics 2008-02-03 Chris Adami

With the boom in modern software development, open-source software has become an integral part of various industries, driving progress in computer science. However, the immense complexity and diversity of the open-source ecosystem also pose…

Software Engineering · Computer Science 2023-11-17 Yueming Wu , Chengwei Liu , Yang Liu

Genetic algorithms are considered as one of the most efficient search techniques. Although they do not offer an optimal solution, their ability to reach a suitable solution in considerably short time gives them their respectable role in…

Neural and Evolutionary Computing · Computer Science 2014-01-22 Ayman M. Bahaa-Eldin , A. M. A. Wahdan , H. M. K. Mahdi

Why is the genetic code the way it is? The most successful theory states that the codon assignments minimise the effects of errors arising in primordial living systems. Here a transversion is reported that leaves invariant degeneracy in the…

Biological Physics · Physics 2007-05-23 Jean-Luc Jestin

Dependently typed programming languages allow sophisticated properties of data to be expressed within the type system. Of particular use in dependently typed programming are indexed types that refine data by computationally useful…

Logic in Computer Science · Computer Science 2015-07-01 Robert Atkey , Patricia Johann , Neil Ghani

The problem of differentiating the informational content of coding (exons) and non-coding (introns) regions of a DNA sequence is one of the central problems of genomics. The introns are estimated to be nearly 95% of the DNA and since they…

Computational Engineering, Finance, and Science · Computer Science 2010-10-21 Riyazuddin Mohammed

There is a class of entropy-coding methods which do not substitute symbols by code words (such as Huffman coding), but operate on intervals or ranges. This class includes three prominent members: conventional arithmetic coding, range…

Information Theory · Computer Science 2025-07-04 Tilo Strutz , Nico Schreiber

Human reasoning can distill principles from observed patterns and generalize them to explain and solve novel problems. The most powerful artificial intelligence systems lack explainability and symbolic reasoning ability, and have therefore…

Machine Learning · Computer Science 2021-11-17 Paul J. Blazek , Kesavan Venkatesh , Milo M. Lin

This paper focuses on Code Generation task that aims at generating relevant code fragments according to given natural language descriptions. In the process of software development, developers often encounter two scenarios. One is requested…

Software Engineering · Computer Science 2024-04-19 Zezhou Yang , Sirong Chen , Cuiyun Gao , Zhenhao Li , Ge Li , Michael Lyu

State-of-the-art language generation models can degenerate when applied to open-ended generation problems such as text completion, story generation, or dialog modeling. This degeneration usually shows up in the form of incoherence, lack of…

Computation and Language · Computer Science 2023-02-15 Kushal Arora , Timothy J. O'Donnell , Doina Precup , Jason Weston , Jackie C. K. Cheung

This study presents the approach to analyzing the evolution of an arbitrary complex system whose behavior is characterized by a set of different time-dependent factors. The key requirement for these factors is only that they must contain an…

Data Analysis, Statistics and Probability · Physics 2020-12-01 Anatolii V. Mokshin , Vladimir V. Mokshin , Diana A. Mirziyarova

The deep Convolutional Neural Network (CNN) is the state-of-the-art solution for large-scale visual recognition. Following basic principles such as increasing the depth and constructing highway connections, researchers have manually…

Computer Vision and Pattern Recognition · Computer Science 2017-03-07 Lingxi Xie , Alan Yuille

A general theoretical framework is put forth to organize and understand various observed phenomena and mathematical relationships in the field of molecular biology. By modeling each cell in eukaryotic organisms as a processor having a…

Other Quantitative Biology · Quantitative Biology 2013-12-18 Barry D. Jacobson

What does it mean for a generative AI model to be explainable? The emergent discipline of explainable AI (XAI) has made great strides in helping people understand discriminative models. Less attention has been paid to generative models that…

Human-Computer Interaction · Computer Science 2022-02-11 Jiao Sun , Q. Vera Liao , Michael Muller , Mayank Agarwal , Stephanie Houde , Kartik Talamadupula , Justin D. Weisz

Most of the DNA that composes a complex organism is non-coding and defined as junk. Even the coding part is composed of genes that affect the phenotype differently. Therefore, a random mutation has an effect on the specimen fitness that…

Populations and Evolution · Quantitative Biology 2021-07-19 Mattia Miotto , Lorenzo Monacelli

An iterative decoding algorithm for convolutional codes is presented. It successively processes $N$ consecutive blocks of the received word in order to decode the first block. A bound is presented showing which error configurations can be…

Information Theory · Computer Science 2009-08-07 H. Gluesing-Luerssen , U. Helmke , J. I. Iglesias Curto

The determination of block-entropies is a well established method for the investigation of discrete data, also called symbols (7). There is a large variety of such symbolic sequences, ranging from texts written in natural languages,…

Disordered Systems and Neural Networks · Physics 2007-05-23 Miguel Angel Jimenez-Montano , Werner Ebeling , Thorsten Poeschel

A new family of codes, called clustering-correcting codes, is presented in this paper. This family of codes is motivated by the special structure of data that is stored in DNA-based storage systems. The data stored in these systems has the…

Information Theory · Computer Science 2019-03-12 Tal Shinkar , Eitan Yaakobi , Andreas Lenz , Antonia Wachter-Zeh

Understanding binary code is an essential but complex software engineering task for reverse engineering, malware analysis, and compiler optimization. Unlike source code, binary code has limited semantic information, which makes it…

Software Engineering · Computer Science 2022-10-12 Yifan Zhang
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