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Image simulation remains under-exploited for the most widely used biological phase microscopy methods, because of difficulties in simulating partially coherent illumination. We describe an open-source toolbox, microlith…

Optics · Physics 2014-05-14 Shalin B. Mehta , Rudolf Oldenbourg

Biomolecular logic systems processing biochemical input signals and producing "digital" outputs in the form of YES/NO were developed for analysis of physiological conditions characteristic of liver injury, soft tissue injury and abdominal…

Soft Condensed Matter · Physics 2011-11-28 Jan Halamek , Jian Zhou , Lenka Halamkova , Vera Bocharova , Vladimir Privman , Joseph Wang , Evgeny Katz

We introduce SoftTiger, a clinical large language model (CLaM) designed as a foundation model for healthcare workflows. The narrative and unstructured nature of clinical notes is a major obstacle for healthcare intelligentization. We…

Computation and Language · Computer Science 2024-08-21 Ye Chen , Igor Couto , Wei Cai , Cong Fu , Bruno Dorneles

In this article we test the accuracy of three platforms used in computational modelling: MatLab, Octave and Scilab, running on i386 architecture and three operating systems (Windows, Ubuntu and Mac OS). We submitted them to numerical tests…

Mathematical Software · Computer Science 2012-07-10 Eliana S. de Almeida , Antonio C. Medeiros , Alejandro C. Frery

Testing is one of the most important steps in software development. It ensures the quality of software. Continuous Integration (CI) is a widely used testing system that can report software quality to the developer in a timely manner during…

Distributed, Parallel, and Cluster Computing · Computer Science 2020-07-22 Jieyang Chen , Qiang Guan , Li-Ta Lo , Patricia Grubel , Tim Randles

Scientific open-source software (OSS) has greatly benefited research communities through its transparent and collaborative nature. Given its critical role in scientific research, ensuring the sustainability of such software has become…

Software Engineering · Computer Science 2024-02-26 Jiayi Sun , Aarya Patil , Youhai Li , Jin L. C. Guo , Shurui Zhou

We introduce bia-binder (BioImage Archive Binder), an open-source, cloud-architectured, and web-based coding environment tailored to bioimage analysis that is freely accessible to all researchers. The service generates easy-to-use Jupyter…

Quantitative Methods · Quantitative Biology 2024-11-20 Craig T. Russell , Jean-Marie Burel , Awais Athar , Simon Li , Ugis Sarkans , Jason Swedlow , Alvis Brazma , Matthew Hartley , Virginie Uhlmann

Discovery of novel protein biomarkers for clinical applications is an active research field across a manifold of diseases. Despite some successes and progress, the biomarker development pipeline still frequently ends in failure as biomarker…

Biomolecules · Quantitative Biology 2025-05-01 Katharina Waury

Motivation: Bioinformatics software often lacks graphical user interfaces (GUIs), which can limit its adoption by non-technical members of the scientific community. Web interfaces are a common alternative for building cross-platform GUIs,…

Software Engineering · Computer Science 2020-02-21 Andres Veidenberg , Ari Löytynoja

Biomolecule Visualization with Ellipsoidal Coarse-graining (BioVEC) is a tool for visualizing molecular dynamics simulation data while allowing coarse-grained residues to be rendered as ellipsoids. BioVEC reads in configuration files, which…

Soft Condensed Matter · Physics 2009-06-15 E. Abrahamsson , S. S. Plotkin

We present the Open-Source Sleep Monitor and Modulator (OSSMM), an open-source hardware and software platform for accessible sleep research. The OSSMM comprises a small wearable headband built from 3D prints and affordable…

Methodology · Statistics 2026-05-19 Jonny Giordano , Fergal Stapleton , Gabriel Palma , Barak A. Pearlmutter

Bionic vision is a rapidly advancing field aimed at developing visual neuroprostheses ('bionic eyes') to restore useful vision to people who are blind. However, a major outstanding challenge is predicting what people 'see' when they use…

Human-Computer Interaction · Computer Science 2021-02-23 Justin Kasowski , Nathan Wu , Michael Beyeler

Biological and biomedical imaging datasets record the constitution, architecture and dynamics of living organisms across several orders of magnitude of space and time. Imaging technologies are now used throughout the life and biomedical…

Software is vital for the advancement of biology and medicine. Analysis of usage and impact metrics can help developers determine user and community engagement, justify additional funding, encourage additional use, identify unanticipated…

Artificial intelligence (AI) techniques are widely applied in the life sciences. However, applying innovative AI techniques to understand and deconvolute biological complexity is hindered by the learning curve for life science scientists to…

Artificial Intelligence · Computer Science 2024-03-28 Nisha Pillai , Athish Ram Das , Moses Ayoola , Ganga Gireesan , Bindu Nanduri , Mahalingam Ramkumar

Knowledge graphs are an increasingly common data structure for representing biomedical information. These knowledge graphs can easily represent heterogeneous types of information, and many algorithms and tools exist for querying and…

We present DiSH-Sim, a simulator for large discrete models of biological signal transduction pathways, capable of simulating networks with multi-valued elements in both deterministic and stochastic manner. We focus on order of update and…

Molecular Networks · Quantitative Biology 2017-05-09 Khaled Sayed , Yu-Hsin Kuo , Anuva Kulkarni , Natasa Miskov-Zivanov

The latest cancer statistics indicate a decrease in cancer-related mortality. However, due to the growing and ageing population, the absolute number of people living with cancer is set to keep increasing. This paper presents ASCAPE, an open…

Build-time configuration and environment assumptions are hampering progress and usability in scientific software. That which would be utterly unacceptable in non-scientific software somehow passes for the norm in scientific packages. The…

Software Engineering · Computer Science 2014-07-11 Jed Brown , Matthew G. Knepley , Barry F. Smith

BioScape is a concurrent language motivated by the biological landscapes found at the interface of biology and biomaterials. It has been motivated by the need to model antibacterial surfaces, biofilm formation, and the effect of DNAse in…

Logic in Computer Science · Computer Science 2012-11-21 Adriana Compagnoni , Mariangiola Dezani-Ciancaglini , Paola Giannini , Karin Sauer , Vishakha Sharma , Angelo Troina