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One of the basic tasks in bioinformatics is localizing a short subsequence $S$, read while sequencing, in a long reference sequence $R$, like the human geneome. A natural rapid approach would be finding a hash value for $S$ and compare it…

Data Structures and Algorithms · Computer Science 2016-02-19 Jarek Duda

DNA is an attractive medium for digital data storage. When data is stored on DNA, errors occur, which makes error-correcting coding techniques critical for reliable DNA data storage. To reduce the errors, a common technique is to include…

Information Theory · Computer Science 2024-06-27 Franziska Weindel , Andreas L. Gimpel , Robert N. Grass , Reinhard Heckel

Relative Lempel-Ziv (RLZ) is a popular algorithm for compressing databases of genomes from individuals of the same species when fast random access is desired. With Kuruppu et al.'s (SPIRE 2010) original implementation, a reference genome is…

Data Structures and Algorithms · Computer Science 2016-05-17 Anthony J. Cox , Andrea Farruggia , Travis Gagie , Simon J. Puglisi , Jouni Sirén

DNA-based storage is an emerging storage technology that provides high information density and long duration. Due to the physical constraints in the reading and writing processes, error correction in DNA storage poses several interesting…

Information Theory · Computer Science 2023-10-04 Jin Sima , Netanel Raviv , Moshe Schwartz , Jehoshua Bruck

We study the combination of two recent coding approaches, in the context of DNA based data storage. Composite DNA alphabets leverage properties of the DNA synthesis and sequencing process. A composite symbol does not represent a single…

Information Theory · Computer Science 2026-05-20 Tomer Cohen , Eitan Yaakobi , Zohar Yakhini

The large memory requirements of deep neural networks limit their deployment and adoption on many devices. Model compression methods effectively reduce the memory requirements of these models, usually through applying transformations such…

Machine Learning · Computer Science 2017-11-15 Brandon Reagen , Udit Gupta , Robert Adolf , Michael M. Mitzenmacher , Alexander M. Rush , Gu-Yeon Wei , David Brooks

DNA sequence encoding is fundamental to gene function prediction, protein synthesis, and diverse downstream biological tasks. Despite the substantial progress achieved by large-scale DNA sequence pretraining, existing studies have…

Machine Learning · Computer Science 2026-04-21 Zhijiang Tang , Jiaxin Qi , Yan Cui , Jinli Ou , Yuhua Zheng , Jianqiang Huang

We consider the enciphering of a data stream while being compressed by a LZ algorithm. This has to be compared to the classical encryption after compression methods used in security protocols. Actually, most cryptanalysis techniques exploit…

Cryptography and Security · Computer Science 2008-07-22 Bruno Martin

To achieve higher accuracy in machine learning tasks, very deep convolutional neural networks (CNNs) are designed recently. However, the large memory access of deep CNNs will lead to high power consumption. A variety of hardware-friendly…

Image and Video Processing · Electrical Eng. & Systems 2021-06-25 Yubo Shi , Meiqi Wang , Siyi Chen , Jinghe Wei , Zhongfeng Wang

The majority of online content is written in languages other than English, and is most commonly encoded in UTF-8, the world's dominant Unicode character encoding. Traditional compression algorithms typically operate on individual bytes.…

Information Theory · Computer Science 2017-01-17 Adam Gleave , Christian Steinruecken

Data compression is a powerful tool for managing massive but repetitive datasets, especially schemes such as grammar-based compression that support computation over the data without decompressing it. In the best case such a scheme takes a…

Data Structures and Algorithms · Computer Science 2019-06-04 Travis Gagie , Tomohiro I , Giovanni Manzini , Gonzalo Navarro , Hiroshi Sakamoto , Yoshimasa Takabatake

The process of DNA-based data storage (DNA storage for short) can be mathematically modelled as a communication channel, termed DNA storage channel, whose inputs and outputs are sets of unordered sequences. To design error correcting codes…

Information Theory · Computer Science 2020-06-11 Wentu Song , Kui Cai , Kees A. Schouhamer Immink

As a possible implementation of data storage using DNA, multiple strands of DNA are stored in a liquid container so that, in the future, they can be read by an array of DNA readers in parallel. These readers will sample the strands with…

Information Theory · Computer Science 2024-09-04 Hsin-Po Wang , Venkatesan Guruswami

The problem of storing large amounts of information safely for a long period of time has become essential. One of the most promising new data storage mediums are the polymer-based data storage systems, like the DNA-storage system. These…

Information Theory · Computer Science 2025-04-21 Ville Junnila , Tero Laihonen , Tuomo Lehtilä

In the recent years, DNA has emerged as a potentially viable storage technology. DNA synthesis, which refers to the task of writing the data into DNA, is perhaps the most costly part of existing storage systems. Accordingly, this high cost…

Information Theory · Computer Science 2022-04-15 Ohad Elishco , Wasim Huleihel

We show how to compress string dictionaries using the Lempel-Ziv (LZ78) data compression algorithm. Our approach is validated experimentally on dictionaries of up to 1.5 GB of uncompressed text. We achieve compression ratios often…

Data Structures and Algorithms · Computer Science 2013-05-06 Julian Arz , Johannes Fischer

We describe properties and constructions of constraint-based codes for DNA-based data storage which account for the maximum repetition length and AT/GC balance. We present algorithms for computing the number of sequences with maximum…

Information Theory · Computer Science 2018-12-18 Kees A. Schouhamer Immink , Kui Cai

DNA emerges as a promising medium for the exponential growth of digital data due to its density and durability. This study extends recent research by addressing the \emph{coverage depth problem} in practical scenarios, exploring optimal…

Information Theory · Computer Science 2024-02-01 Hadas Abraham , Rayn Gabrys , Eitan Yaakobi

This paper presents a new technique for deterministic length reduction. This technique improves the running time of the algorithm presented in \cite{LR07} for performing fast convolution in sparse data. While the regular fast convolution of…

Data Structures and Algorithms · Computer Science 2008-02-04 Amihood Amir , Klim Efremenko , Oren Kapah , Ely Porat , Amir Rothschild

This paper studies two problems that are motivated by the novel recent approach of composite DNA that takes advantage of the DNA synthesis property which generates a huge number of copies for every synthesized strand. Under this paradigm,…

Information Theory · Computer Science 2025-05-15 Tomer Cohen , Eitan Yaakobi