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This thesis develops computational methods in similarity-preserving hashing, classification, and cancer genomics. Standard space partitioning-based hashing relies on Binary Search Trees (BSTs), but their exponential growth and sparsity…

Machine Learning · Computer Science 2025-08-26 Prashant Gupta

An end-to-end solution for handwritten numeral string recognition is proposed, in which the numeral string is considered as composed of objects automatically detected and recognized by a YoLo-based model. The main contribution of this paper…

Computer Vision and Pattern Recognition · Computer Science 2023-04-04 Andre G. Hochuli , Alceu S. Britto , Jean P. Barddal , Luiz E. S. Oliveira , Robert Sabourin

Publicly available collections of drug-like molecules have grown to comprise 10s of billions of possibilities in recent history due to advances in chemical synthesis. Traditional methods for identifying "hit" molecules from a large…

We present efficient algorithms to generate a bit string in which each bit is set with arbitrary probability. By adopting a hybrid algorithm, i.e., a finite-bit density approximation with correction techniques, we achieve 3.8 times faster…

Statistical Mechanics · Physics 2019-02-07 Hiroshi Watanabe , Satoshi Morita , Synge Todo , Naoki Kawashima

Microbial clades modeling is a challenging problem in biology based on microarray genome sequences, especially in new species gene isolates discovery and category. Marker family genome sequences play important roles in describing specific…

Quantitative Methods · Quantitative Biology 2019-04-22 Jingwei Liu

In the Minimum Common String Partition Problem (MCSP), we are given two strings on input, and we want to partition both into the same collection of substrings, minimizing the number of the substrings in the partition. This combinatorial…

Data Structures and Algorithms · Computer Science 2021-10-12 Miloš Chromý , Markus Sinnl

The current work is focusing on the implementation of a robust watermarking algorithm for digital images, which is based on an innovative spread spectrum analysis algorithm for watermark embedding and on a content-based image retrieval…

Data Structures and Algorithms · Computer Science 2009-09-29 Dimitrios K. Tsolis , Spyros Sioutas , Theodore S. Papatheodorou

In this work we suggest a statistical mechanics approach to the classification of high-dimensional data according to a binary label. We propose an algorithm whose aim is twofold: First it learns a classifier from a relatively small number…

Statistical Mechanics · Physics 2009-07-22 Andrea Pagnani , Francesca Tria , Martin Weigt

Cellular barcoding is a significant, recently developed, biotechnology tool that enables the familial identification of progeny of individual cells in vivo. Most existing approaches rely on ex vivo viral transduction of cells with barcodes,…

Cell Behavior · Quantitative Biology 2016-07-25 Tom S. Weber , Mark Dukes , Denise Miles , Stefan Glaser , Shalin Naik , Ken R. Duffy

DNA-based storage is an emerging technology that enables digital information to be archived in DNA molecules. This method enjoys major advantages over magnetic and optical storage solutions such as exceptional information density, enhanced…

Information Theory · Computer Science 2024-03-13 Daniella Bar-Lev , Itai Orr , Omer Sabary , Tuvi Etzion , Eitan Yaakobi

We develop a highly scalable optimization method called "hierarchical group-thresholding" for solving a multi-task regression model with complex structured sparsity constraints on both input and output spaces. Despite the recent emergence…

Machine Learning · Statistics 2012-08-16 Seunghak Lee , Eric P. Xing

Enzymatic DNA labeling is a powerful tool with applications in biochemistry, molecular biology, biotechnology, medical science, and genomic research. This paper contributes to the evolving field of DNA-based data storage by presenting a…

Information Theory · Computer Science 2024-05-15 Daniella Bar-Lev , Tuvi Etzion , Eitan Yaakobi , Zohar Yakhini

We consider the problem of coding for the substring channel, in which information strings are observed only through their (multisets of) substrings. Due to existing DNA sequencing techniques and applications in DNA-based storage systems,…

Information Theory · Computer Science 2024-03-27 Yonatan Yehezkeally , Nikita Polyanskii

We describe a family of highly efficient codes for cryptographic purposes and dedicated algorithms for their manipulation. Our proposal is especially tailored for highly constrained platforms, and surpasses certain conventional and…

Cryptography and Security · Computer Science 2012-12-19 Felipe P. Biasi , Paulo S. L. M. Barreto , Rafael Misoczki , Wilson V. Ruggiero

The study of strings is an important combinatorial field that precedes the digital computer. Strings can be very long, trillions of letters, so it is important to find compact representations. Here we first survey various forms of one…

Data Structures and Algorithms · Computer Science 2026-04-08 Neerja Mhaskar , W. F. Smyth

We provide an overview of current approaches to DNA-based storage system design and accompanying synthesis, sequencing and editing methods. We also introduce and analyze a suite of new constrained coding schemes for both archival and random…

Emerging Technologies · Computer Science 2015-07-08 S. M. Hossein Tabatabaei Yazdi , Han Mao Kiah , Eva Ruiz Garcia , Jian Ma , Huimin Zhao , Olgica Milenkovic

Structural variants compose the majority of human genetic variation, but are difficult to assess using current genomic sequencing technologies. Optical mapping technologies, which measure the size of chromosomal fragments between labeled…

Quantitative Methods · Quantitative Biology 2019-10-10 Weiwei Li , Jan Hannig , Corbin Jones

We develop a scalable algorithm to learn binary hash codes for indexing large-scale datasets. Near-isometric binary hashing (NIBH) is a data-dependent hashing scheme that quantizes the output of a learned low-dimensional embedding to obtain…

Data Structures and Algorithms · Computer Science 2016-03-15 Amirali Aghazadeh , Andrew Lan , Anshumali Shrivastava , Richard Baraniuk

The Set Covering Machine (SCM) is a greedy learning algorithm that produces sparse classifiers. We extend the SCM for datasets that contain a huge number of features. The whole genetic material of living organisms is an example of such a…

As sequencing technologies become more affordable and genomic databases expand continuously, the reuse of publicly available sequencing data emerges as a powerful strategy for studying microbial pathogens. Indeed, raw sequencing reads…

Quantitative Methods · Quantitative Biology 2025-05-16 Damien Richard , Nils Poulicard