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Laser-induced alignment of particles and molecules was long envisioned to support three-dimensional structure determination using "single-molecule diffraction" with x-ray free-electron lasers [PRL 92, 198102 (2004)]. However, the alignment…

Computational Physics · Physics 2025-02-05 Muhamed Amin , Jean-Michel Hartmann , Amit K. Samanta , Jochen Küpper

Despite a variety of available techniques the issue of the proper regularization parameter choice for inverse problems still remains one of the biggest challenges. The main difficulty lies in constructing a rule, allowing to compute the…

Numerical Analysis · Mathematics 2017-10-13 Ernesto De Vito , Massimo Fornasier , Valeriya Naumova

Quantum query complexity is typically characterized in terms of XOR queries |x,y> to |x,y+f(x)> or phase queries, which ensure that even queries to non-invertible functions are unitary. When querying a permutation, another natural model is…

Quantum Physics · Physics 2025-09-18 Blake Holman , Ronak Ramachandran , Justin Yirka

Inverse imaging problems that are ill-posed can be encountered across multiple domains of science and technology, ranging from medical diagnosis to astronomical studies. To reconstruct images from incomplete and distorted data, it is…

Image and Video Processing · Electrical Eng. & Systems 2023-11-30 Cesar F. Caiafa , Ramiro M. Irastorza

We propose a method to reconstruct the 3-D molecular structure from micrographs collected at just one sample tilt angle in the random conical tilt scheme in cryo-electron microscopy. Our method uses autocorrelation analysis on the…

Data Analysis, Statistics and Probability · Physics 2021-01-12 Ti-Yen Lan , Nicolas Boumal , Amit Singer

Computational complexity is a core theory of computer science, which dictates the degree of difficulty of computation. There are many problems with high complexity that we have to deal, which is especially true for AI. This raises a big…

Computational Complexity · Computer Science 2023-01-10 Chuyu Xiong

A wide range of problems in computational science and engineering require estimation of sparse eigenvectors for high dimensional systems. Here, we propose two variants of the Truncated Orthogonal Iteration to compute multiple leading…

Numerical Analysis · Mathematics 2021-03-26 Hexuan Liu , Aleksandr Aravkin

This paper studies the problem of exact localization of sparse (point or extended) objects with noisy data. The crux of the proposed approach consists of random illumination. Several recovery methods are analyzed: the Lasso, BPDN and the…

Information Theory · Computer Science 2015-05-19 Albert Fannjiang

The TTE approach to Computable Analysis is the study of so-called representations (encodings for continuous objects such as reals, functions, and sets) with respect to the notions of computability they induce. A rich variety of such…

Computational Complexity · Computer Science 2023-06-22 Carsten Rösnick-Neugebauer

Compressive approaches provide a means of effective channel high resolution channel estimates in millimeter wave MIMO systems, despite the use of analog and hybrid architectures. Such estimates can also be used as part of a joint channel…

Signal Processing · Electrical Eng. & Systems 2022-04-08 Joan Palacios , Nuria González-Prelcic , Cristian Rusu

Multi-reference alignment (MRA) is the problem of recovering a signal from its multiple noisy copies, each acted upon by a random group element. MRA is mainly motivated by single-particle cryo-electron microscopy (cryo-EM) that has recently…

Information Theory · Computer Science 2023-08-15 Tamir Bendory , Dan Edidin

Single-particle cryo-electron microscopy (cryo-EM) has recently joined X-ray crystallography and NMR spectroscopy as a high-resolution structural method to resolve biological macromolecules. In a cryo-EM experiment, the microscope produces…

Information Theory · Computer Science 2022-10-28 Tamir Bendory , Nicolas Boumal , William Leeb , Eitan Levin , Amit Singer

We revisit the classification of polarization observables of the cosmic microwave background. There exists a unified approach to the $3 \times 3$ density matrix by which intensity, linear and circular polarization are treated on an equal…

Astrophysics · Physics 2007-05-23 John P. Ralston , Pankaj Jain

Binary Hashing is widely used for effective approximate nearest neighbors search. Even though various binary hashing methods have been proposed, very few methods are feasible for extremely high-dimensional features often used in visual…

Computer Vision and Pattern Recognition · Computer Science 2015-01-30 Kohta Ishikawa , Ikuro Sato , Mitsuru Ambai

In this paper we the formulation of inverse problems as constrained minimization problems and their iterative solution by gradient or Newton type. We carry out a convergence analysis in the sense of regularization methods and discuss…

Numerical Analysis · Mathematics 2021-01-15 Barbara Kaltenbacher , Kha Van Huynh

Our study provides evidence that CNNs struggle to effectively extract orientation features. We show that the use of Complex Structure Tensor, which contains compact orientation features with certainties, as input to CNNs consistently…

Computer Vision and Pattern Recognition · Computer Science 2024-04-25 Kevin Hernandez-Diaz , Josef Bigun , Fernando Alonso-Fernandez

X-ray single particle imaging involves the measurement of a large number of noisy diffraction patterns of isolated objects in random orientations. The missing information about these patterns is then computationally recovered in order to…

Image and Video Processing · Electrical Eng. & Systems 2020-05-25 Kartik Ayyer

The rich information content of measurements in the molecular frame rather than the laboratory frame has motivated the development of several methods for aligning gas phase molecules in space. Even so, for asymmetric tops the problem of…

Atomic Physics · Physics 2016-11-23 Varun Makhija , Xiaoming Ren , Drue Gockel , Anh-Thu Le , Vinod Kumarappan

Various techniques have been developed to measure the 2D and 3D positions and 2D and 3D orientations of fluorescent molecules with improved precision over standard epifluorescence microscopes. Due to the challenging signal-to-background…

Optics · Physics 2021-02-02 Oumeng Zhang , Matthew D. Lew

We examine the computational complexity of testing and finding small plans in probabilistic planning domains with both flat and propositional representations. The complexity of plan evaluation and existence varies with the plan type sought;…

Artificial Intelligence · Computer Science 2007-05-23 M. L. Littman , J. Goldsmith , M. Mundhenk