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We study the conditions on the physical parameters in the Helfrich bending energy of lipid bilayer vesicles. Among embedded surfaces with a biconcave axisymmetric shape, the variation equation is analyzed in detail. This leads to simple…

Analysis of PDEs · Mathematics 2007-05-23 Thomas Kwok-keung Au , Tom Yau-heng Wan

The equilibrium shapes of vesicles are governed by the general shape equation which is derived from the minimization of the Helfrich elastic free energy and can be reduced to the Willmore equation in a special case. The general shape…

Soft Condensed Matter · Physics 2017-08-28 Xiaohua Zhou

The Helfrich's shape equation of axisymmetric vesicles is studied. A sufficient condition on the physical parameters and some geometric properties are discovered for the biconcave shape.

Biological Physics · Physics 2009-09-25 Thomas Kwok-keung Au , Tom Yau-heng Wan

We address the geometric Cauchy problem for surfaces associated to the membrane shape equation describing equilibrium configurations of vesicles formed by lipid bilayers. This is the Euler-Lagrange equation of the Canham-Helfrich-Evans…

Differential Geometry · Mathematics 2014-11-18 Gary R. Jensen , Emilio Musso , Lorenzo Nicolodi

Within the framework of the well-known curvature models, a fluid lipid bilayer membrane is regarded as a surface embedded in the three-dimensional Euclidean space whose equilibrium shapes are described in terms of its mean and Gaussian…

Mathematical Physics · Physics 2009-10-22 V. M. Vassilev , P. A. Djondjorov , I. M. Mladenov

We conduct a systematic exploration of the energy landscape of vesicle morphologies within the framework of the Helfrich model. Vesicle shapes are determined by minimizing the elastic energy subject to constraints of constant area and…

Soft Condensed Matter · Physics 2023-11-27 Rodrigo B. Reboucas , Hammad A. Faizi , Michael J. Miksis , Petia M. Vlahovska

Whatever the fluid lipid vesicle is modeled as the spontaneous-curvature, bilayer-coupling, or the area-difference elasticity, and no matter whether a pulling axial force applied at the vesicle poles or not, a universal shape equation…

Soft Condensed Matter · Physics 2007-05-23 B. Hu , Q. H. Liu , J. X. Liu , X. Wang , H. Zhang , O. Y. Zhong-Can

The Helfrich energy is commonly used to model the elastic bending energy of lipid bilayers in membrane mechanics. The governing differential equations for certain geometric characteristics of the shape of the membrane can be obtained by…

Numerical Analysis · Mathematics 2020-05-27 P. Rangamani , A. Behzadan , M. Holst

A phase-field model that takes into account the bending energy of fluid vesicles is presented. The Canham-Helfrich model is derived in the sharp-interface limit. A dynamic equation for the phase-field has been solved numerically to find…

Soft Condensed Matter · Physics 2007-05-23 F. Campelo , A. Hernandez-Machado

The surface free energy of ideal hard rods near curved hard surfaces is determined to second order in curvature for surfaces of general shape. In accordance with previous results for spherical and cylindrical surfaces it is found that this…

Soft Condensed Matter · Physics 2009-10-31 B. Groh

We consider a well known model for lipid-bilayer membrane vesicles exhibiting phase separation, incorporating a phase field with finite curvature elasticity. We prove the existence of a plethora of equilibria, corresponding to…

Analysis of PDEs · Mathematics 2018-12-11 Timothy J. Healey , Sanjay Dharmavaram

Motivated by recent studies of two-phase lipid vesicles possessing 2D solid domains integrated within a fluid bilayer phase, we study the shape equilibria of closed vesicles possessing a single planar, circular inclusion. While 2D solid…

Soft Condensed Matter · Physics 2024-04-16 Geunwoong Jeon , Justin Fagnoni , Hao Wan , Maria M. Santore , Gregory M. Grason

Coarse-grained continuous descriptions for lipid bilayers are typically based on minimizing the Helfrich energy. Such models consider the fluid properties of these structures only implicitly and have been shown to nicely reproduce…

Soft Condensed Matter · Physics 2026-04-29 Ingo Nitschke , Jan Magnus Sischka , Axel Voigt

A phase field model for dealing with shape instabilities in fluid membrane vesicles is presented. This model takes into account the Canham-Helfrich bending energy with spontaneous curvature. A dynamic equation for the phase-field is also…

Soft Condensed Matter · Physics 2007-07-26 F. Campelo , A. Hernandez-Machado

The adhesion of a lipid membrane vesicle to a fixed substrate is examined from a geometrical point of view. This vesicle is described by the Helfrich hamiltonian quadratic in mean curvature; it interacts by contact with the substrate, with…

Soft Condensed Matter · Physics 2009-11-07 Riccardo Capovilla , Jemal Guven

Recent theoretical advances in elasticity of membranes following Helfrich's famous spontaneous curvature model are summarized in this review. The governing equations describing equilibrium configurations of lipid vesicles, lipid membranes…

Soft Condensed Matter · Physics 2017-07-27 Z. C. Tu , Z. C. Ou-Yang

The issue of different parameterizations of the axisymmetric vesicle shape addressed by Hu Jian-Guo and Ou-Yang Zhong-Can [ Phys.Rev. E {\bf 47} (1993) 461 ] is reassesed, especially as it transpires through the corresponding Euler -…

Condensed Matter · Physics 2009-10-22 R. Podgornik , S. Svetina , B. Žekš

The Helfrich bending energy plays an important role in providing a mechanism for the conformation of a lipid vesicle in theoretical biophysics, which is governed by the principle of energy minimization over configurations of appropriate…

Soft Condensed Matter · Physics 2018-06-20 Yisong Yang

Correctly formulated continuum models for lipid-bilayer membranes present a significant challenge to computational mechanics. In particular, the mid-surface behavior is that of a 2-dimensional fluid, while the membrane resists bending much…

Soft Condensed Matter · Physics 2017-03-08 Siming Zhao , Timothy Healey , Qingdu Li

Combining local bifurcation analysis with numerical continuation and bifurcation methods we study bifurcations from cylindrical vesicles described by the Helfrich equation with volume and area constraints, with a prescribed periodicity…

Analysis of PDEs · Mathematics 2025-08-08 Alexander Meiners , Hannes Uecker
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