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In large populations, multiple beneficial mutations may be simultaneously spreading. In asexual populations, these mutations must either arise on the same background or compete against each other. In sexual populations, recombination can…

Populations and Evolution · Quantitative Biology 2013-12-19 D. B. Weissman , O. Hallatschek

Both evolution and ecology have long been concerned with the impact of variable environmental conditions on observed levels of genetic diversity within and between species. We model the evolution of a quantitative trait under selection that…

Populations and Evolution · Quantitative Biology 2014-11-17 Hannes Svardal , Claus Rueffler , Joachim Hermisson

Coalescent processes, including mutation, are derived from Moran type population models admitting large offspring numbers. Including mutation in the coalescent process allows for quantifying the turnover of alleles by computing the…

Populations and Evolution · Quantitative Biology 2012-12-11 Bjarki Eldon

Whether evolution can be predicted is a key question in evolutionary biology. Here we set out to better understand the repeatability of evolution. We explored experimentally the effect of mutation supply and the strength of selective…

Populations and Evolution · Quantitative Biology 2017-09-13 Thomas van Dijk , Sungmin Hwang , Joachim Krug , J. Arjan G. M. de Visser , Mark P. Zwart

We study the long-time behaviour of a population structured by age and a phenotypic trait under a selection-mutation dynamics. By analysing spectral properties of a family of positive operators on measure spaces, we show the existence of…

Analysis of PDEs · Mathematics 2018-05-28 Tristan Roget

In this article we present a new p-adic generalization of the Eigen-Schuster model where the genomes (sequences) are represented by words written in the alphabet 0,1,,p-1, where p is a prime number, with a time variable length. The time…

Populations and Evolution · Quantitative Biology 2022-06-22 W. A. Zúñiga-Galindo

We introduce a population dynamics model, where individual genomes are represented by bit-strings. Selection is described by death probabilities which depend on these genomes, and new individuals continuously replace the ones that die,…

Statistical Mechanics · Physics 2009-11-10 P. M. C. de Oliveira , J. S. Sa' Martins , D. Stauffer , S. Moss de Oliveira

We study the evolution of allele frequencies in a large population where random mating is violated in a particular way that is related to recent works on speciation. Specifically, we consider non-random encounters in haploid organisms…

Populations and Evolution · Quantitative Biology 2013-09-05 David M. Schneider , Ayana B. Martins , Eduardo do Carmo , Marcus A. M. de Aguiar

We introduce a stochastic model of a population with overlapping generations and arbitrary levels of self-fertilization versus outcrossing. We study how the global graph of reproductive relationships, or population pedigree, influences the…

Populations and Evolution · Quantitative Biology 2025-05-20 Maximillian Newman , John Wakeley , Wai-Tong Louis Fan

We consider a stochastic model describing a constant size $N$ population that may be seen as a directed polymer in random medium with $N$ sites in the transverse direction. The population dynamics is governed by a noisy traveling wave…

Probability · Mathematics 2016-06-07 Aser Cortines

This article presents a comprehensive study of the continuous McKendrick model, which serves as a foundational framework in population dynamics and epidemiology. The model is formulated through partial differential equations that describe…

Populations and Evolution · Quantitative Biology 2026-01-23 Dragos-Patru Covei

Genetically identical cells in the same population can take on phenotypically variable states, leading to differentiated responses to external signals, such as nutrients and drug-induced stress. Many models and experiments have focused on a…

Molecular Networks · Quantitative Biology 2015-04-28 Thierry Mora , Aleksandra M. Walczak

This paper extends earlier work by Cox and Durrett, who studied the coalescence times for two lineages in the stepping stone model on the two-dimensional torus. We show that the genealogy of a sample of size n is given by a time change of…

Probability · Mathematics 2007-05-23 Iljana Zahle , J. Theodore Cox , Richard Durrett

We pursue the task of developing a finite population counterpart to Eigen's model. We consider the classical Wright-Fisher model describing the evolution of a population of size $m$ of chromosomes of length $\ell$ over an alphabet of…

Probability · Mathematics 2016-08-14 Raphaël Cerf

Genetic diversity is central to the process of evolution. Both natural selection and random genetic drift are influenced by the level of genetic diversity of a population; selection acts on diversity while drift samples from it. At a given…

Populations and Evolution · Quantitative Biology 2024-11-12 Nikolas Vellnow , Toni I. Gossmann , David Waxman

We consider birth-and-death stochastic evolution of genotypes with different lengths. The genotypes might mutate that provides a stochastic changing of lengthes by a free diffusion law. The birth and death rates are length dependent which…

Populations and Evolution · Quantitative Biology 2015-06-16 Dmitri Finkelshtein , Yuri Kondratiev , Oleksandr Kutoviy , Stanislav Molchanov , Elena Zhizhina

With a view to connecting random mutation on the molecular level to punctuated equilibrium behavior on the phenotype level, we propose a new model for biological evolution, which incorporates random mutation and natural selection. In this…

Condensed Matter · Physics 2009-10-28 M. Y. Choi , H. Y. Lee , D. Kim , S. H. Park

Several results of large deviations are obtained for distributions that are associated with the Poisson--Dirichlet distribution and the Ewens sampling formula when the parameter $\theta$ approaches infinity. The motivation for these results…

Probability · Mathematics 2007-11-06 Shui Feng

We study a continuous time model for the frequency distribution of an infinitely large asexual population in which both beneficial and deleterious mutations occur and the fitness is additive. When beneficial mutations are ignored, the exact…

Populations and Evolution · Quantitative Biology 2016-10-27 Kavita Jain , Sona John

We review models of biological evolution in which the population frequency changes deterministically with time. If the population is self-replicating, although the equations for simple prototypes can be linearised, nonlinear equations arise…

Populations and Evolution · Quantitative Biology 2015-05-27 Kavita Jain , Sarada Seetharaman
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