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The fundamental understanding of how cells physically interact with each other and their environment is key to understanding their organisation in living tissues. Over the past decades several computational methods have been developed to…

Quantitative Methods · Quantitative Biology 2026-01-22 Paul Van Liedekerke , Jiří Pešek , Kevin Alessandri , Dirk Drasdo

Understanding the rules underlying organismal development is a major unsolved problem in biology. Each cell in a developing organism responds to signals in its local environment by dividing, excreting, consuming, or reorganizing, yet how…

Cell Behavior · Quantitative Biology 2025-08-20 Ramya Deshpande , Francesco Mottes , Ariana-Dalia Vlad , Michael P. Brenner , Alma dal Co

This is a survey article on trees, with a modest number of proofs to give a flavor of the way these topologies can be efficiently handled. Trees are defined in set-theorist fashion as partially ordered sets in which the elements below each…

General Topology · Mathematics 2007-05-23 Peter J. Nyikos

Complex systems are usually represented as an intricate set of relations between their components forming a complex graph or network. The understanding of their functioning and emergent properties are strongly related to their structural…

Data Analysis, Statistics and Probability · Physics 2014-01-08 Sergio Gomez , Alberto Fernandez , Clara Granell , Alex Arenas

The technique presented here identifies tethered mould designs, optimised for growing cultured tissue with very highly-aligned cells. It is based on a microscopic biophysical model for polarised cellular hydrogels. There is an unmet need…

Biological Physics · Physics 2023-06-26 James P. Hague , Allison E. Andrews , Hugh Dickinson

Starting from the hypothesis that both physics, in particular space-time and the physical vacuum, and the corresponding mathematics are discrete on the Planck scale we develop a certain framework in form of a class of ' cellular networks'…

High Energy Physics - Theory · Physics 2016-09-06 Manfred Requardt

We discuss a notion of convergence for binary trees that is based on subtree sizes. In analogy to recent developments in the theory of graphs, posets and permutations we investigate some general aspects of the topology, such as a…

Combinatorics · Mathematics 2024-02-14 Rudolf Grübel

Good statistics for measuring large-scale structure in the Universe must be able to distinguish between different models of structure formation. In this paper, two and three dimensional ``counts in cell" statistics and a new ``discrete…

Astrophysics · Physics 2007-05-23 Robert H. Brandenberger , David M. Kaplan , Stephen A , Ramsey

We investigate the structure of two-dimensional partial cubes, i.e., of isometric subgraphs of hypercubes whose vertex set defines a set family of VC-dimension at most 2. Equivalently, those are the partial cubes which are not contractible…

Combinatorics · Mathematics 2021-05-20 Victor Chepoi , Kolja Knauer , Manon Philibert

The study of network structure has uncovered signatures of the organization of complex systems. However, there is also a need to understand how to control them; for example, identifying strategies to revert a diseased cell to a healthy…

Molecular Networks · Quantitative Biology 2016-04-19 Alexander J. Gates , Luis M. Rocha

A long-standing challenge is designing multi-scale structures with good connectivity between cells while optimizing each cell to reach close to the theoretical performance limit. We propose a new method for direct multi-scale topology…

Neural and Evolutionary Computing · Computer Science 2025-02-21 Hongrui Chen , Xingchen Liu , Levent Burak Kara

Functional networks of complex systems are obtained from the analysis of the temporal activity of their components, and are often used to infer their unknown underlying connectivity. We obtain the equations relating topology and function in…

Disordered Systems and Neural Networks · Physics 2015-03-18 Víctor M. Eguíluz , Toni Pérez , Javier Borge-Holtoefer , Alex Arenas

Trees are partial orders in which every element has a linearly ordered set of predecessors. Here we initiate the exploration of the structural theory of trees with the study of different notions of \emph{branching in trees} and of…

Combinatorics · Mathematics 2023-01-18 Valentin Goranko , Ruaan Kellerman , Alberto Zanardo

We present a new and efficient optimization method to determine the structure of disordered systems in agreement with available experimental data. Our approach permits the application of accurate electronic structure calculations within the…

Materials Science · Physics 2014-06-23 Jan H. Los , Thomas D. Kühne

We use a simple fragmentation model to describe the statistical behavior of the Voronoi cell patterns generated by a set of points in 1D and in 2D. In particular, we are interested in the distribution of sizes of these Voronoi cells. Our…

Statistical Mechanics · Physics 2011-11-30 Diego Luis Gonzalez Cabrera , T. L. Einstein

Complex network theory aims to model and analyze complex systems that consist of multiple and interdependent components. Among all studies on complex networks, topological structure analysis is of the most fundamental importance, as it…

Social and Information Networks · Computer Science 2010-09-15 Bo Yang , Jiming Liu

The recent discovery of universal principles underlying many complex networks occurring across a wide range of length scales in the biological world has spurred physicists in trying to understand such features using techniques from…

Biological Physics · Physics 2015-05-13 Sitabhra Sinha

The orientation of cell division is a major determinant of three-dimensional plant morphogenesis. Whether and how a simple division orientation rule explains the establishment of symmetric body plans is a fundamental question. Testing such…

Cell Behavior · Quantitative Biology 2026-05-14 Naoya Kamamoto , Koichi Fujimoto

Complex systems have motivated continuing interest from the scientific community, leading to new concepts and methods. Growing systems represent a case of particular interest, as their topological, geometrical, and also dynamical properties…

Social and Information Networks · Computer Science 2024-05-27 Alexandre Benatti , Roberto M. Cesar , Luciano da F. Costa

We study topological properties of automorphisms of 4-dimensional torus generated by integer symplectic matrices. The main classifying element is the structure of the topology of a foliation generated by unstable leaves of the automorphism.…

Dynamical Systems · Mathematics 2020-01-30 L. M. Lerman , K. N. Trifonov