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It is a long-standing question in origin-of-life research whether the information content of replicating molecules can be maintained in the presence of replication errors. Extending standard quasispecies models of non-enzymatic replication,…

Populations and Evolution · Quantitative Biology 2009-12-03 B. Obermayer , E. Frey

For a class of stochastic restart algorithms we address the effect of a nonzero level of randomization in maximizing the convergence rate for general energy landscapes. The resulting characterization of the optimal level of randomization is…

Optimization and Control · Mathematics 2025-10-20 Ted Theodosopoulos

Cross-entropy (CE) is the default training loss for supervised classification, but its sample efficiency is limited when labels are scarce. Existing remedies primarily act on the data side, via augmentation, synthesis, or transfer from…

Machine Learning · Computer Science 2026-05-12 Qipeng Zhan , Zhuoping Zhou , Li Shen

Various recent experimental results show that large language models (LLM) exhibit emergent abilities that are not present in small models. System performance is greatly improved after passing a certain critical threshold of scale. In this…

Computation and Language · Computer Science 2023-03-24 Cheng-Shang Chang

Describing the evolution of a population of genomes evolving in a complex fitness landscape is generally very hard. We here introduce an approximate Gaussian closure scheme to characterize analytically the statistics of a genomic population…

Statistical Mechanics · Physics 2021-02-03 Eugenio Mauri , Simona Cocco , Rémi Monasson

We demonstrate that, for a range of state-of-the-art machine learning algorithms, the differences in generalisation performance obtained using default parameter settings and using parameters tuned via cross-validation can be similar in…

Machine Learning · Computer Science 2017-03-21 Anthony Bagnall , Gavin C. Cawley

The fuel-driven process of replication in living systems generates distributions of copied entities with varying degrees of copying accuracy. Here we introduce a thermodynamically consistent ensemble for investigating universal population…

Statistical Mechanics · Physics 2025-02-18 Arthur Genthon , Carl D. Modes , Frank Jülicher , Stephan W. Grill

Motivated by empirical observations of prolonged plateaus and stage-wise progression during training, we investigate the loss landscape of transformer models trained on in-context next-token prediction tasks. In particular, we focus on…

Machine Learning · Computer Science 2025-08-20 Aditya Varre , Gizem Yüce , Nicolas Flammarion

When biological populations expand into new territory, the evolutionary outcomes can be strongly influenced by genetic drift, the random fluctuations in allele frequencies. Meanwhile, spatial variability in the environment can also…

Populations and Evolution · Quantitative Biology 2024-06-27 Jimmy Gonzalez Nuñez , Jayson Paulose , Wolfram Möbius , Daniel A. Beller

We define a general class of network formation models, Statistical Exponential Random Graph Models (SERGMs), that nest standard exponential random graph models (ERGMs) as a special case. We provide the first general results on when these…

Physics and Society · Physics 2014-06-26 Arun G. Chandrasekhar , Matthew O. Jackson

We consider the classical Wright-Fisher model with mutation and selection. Mutations occur independently in each locus, and selection is performed according to the sharp peak landscape. In the asymptotic regime studied in [3], a…

Probability · Mathematics 2014-03-28 Joseba Dalmau

Maximum-entropy ensembles are key primitives in statistical mechanics from which thermodynamic properties can be derived. Over the decades, several approaches have been put forward in order to justify from minimal assumptions the use of…

Quantum Physics · Physics 2018-03-13 Paul Boes , Henrik Wilming , Jens Eisert , Rodrigo Gallego

We argue that in fully-connected networks a phase transition delimits the over- and under-parametrized regimes where fitting can or cannot be achieved. Under some general conditions, we show that this transition is sharp for the hinge loss.…

Machine Learning · Computer Science 2020-01-08 Stefano Spigler , Mario Geiger , Stéphane d'Ascoli , Levent Sagun , Giulio Biroli , Matthieu Wyart

We study structural equation modeling (SEM) for diffusion processes with jumps. Based on high-frequency data, we consider the parameter estimation and the goodness-of-fit test in the SEM. Using a threshold method, we propose the…

Statistics Theory · Mathematics 2025-05-20 Shogo Kusano , Masayuki Uchida

We develop an empirical likelihood (EL) framework for random forests and related ensemble methods, providing a likelihood-based approach to quantify their statistical uncertainty. Exploiting the incomplete $U$-statistic structure inherent…

Machine Learning · Statistics 2025-11-19 Harold D. Chiang , Yukitoshi Matsushita , Taisuke Otsu

This work provides a theoretical framework for assessing the generalization error of graph neural networks in the over-parameterized regime, where the number of parameters surpasses the quantity of data points. We explore two widely…

Machine Learning · Statistics 2024-07-02 Gholamali Aminian , Yixuan He , Gesine Reinert , Łukasz Szpruch , Samuel N. Cohen

Large sets of genotypes give rise to the same phenotype because phenotypic expression is highly redundant. Accordingly, a population can accept mutations without altering its phenotype, as long as thegenotype mutates into another one on the…

Populations and Evolution · Quantitative Biology 2015-02-18 Susanna Manrubia , José A. Cuesta

In many applications of evolutionary algorithms the computational cost of applying operators and storing populations is comparable to the cost of fitness evaluation. Furthermore, by knowing what exactly has changed in an individual by an…

Neural and Evolutionary Computing · Computer Science 2023-06-30 Maxim Buzdalov

We define a dynamic model of random networks, where new vertices are connected to old ones with a probability proportional to a sublinear function of their degree. We first give a strong limit law for the empirical degree distribution, and…

Probability · Mathematics 2008-07-31 Steffen Dereich , Peter Morters

Random forests are ensemble learning methods introduced by Breiman (2001) that operate by averaging several decision trees built on a randomly selected subspace of the data set. Despite their widespread use in practice, the respective roles…

Statistics Theory · Mathematics 2016-03-15 Roxane Duroux , Erwan Scornet