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A two-component model is developed that consists of a discrete loop of cardiac cells that circulates action potentials together with a cardiac pacing mechanism. Physiological properties of cells such as restitutions of refractoriness and of…

Adaptation and Self-Organizing Systems · Physics 2014-01-16 H. Sedaghat , M. A. Wood , J. W. Cain , C-K. Cheng , C. M. Baumgarten , D. M. Chan

In this numerical study, we investigate the role of intrinsic heterogeneities of cardiac tissue due to M cells in the generation and maintenance of reentrant excitations using the detailed Luo-Rudy dynamic model. This model has been…

Tissues and Organs · Quantitative Biology 2007-05-23 Hervé Henry , Wouter-Jan Rappel

Reentrant waves propagating in a ring or annulus of excitable media model is the basic mechanism underlying a major class of irregular cardiac rhythms known as anatomical reentry. Such reentrant waves are terminated by rapid electrical…

Chaotic Dynamics · Physics 2009-11-07 Sitabhra Sinha , David J. Christini

Arrhythmias are potentially fatal disruptions to the normal heart rhythm, but their underlying dynamics is still poorly understood. Theoretical modeling is an important tool to fill this gap. Typical studies often employ detailed…

Tissues and Organs · Quantitative Biology 2022-03-08 R. V. Stenzinger , M. H. R. Tragtenberg

Loop formation between monomers in the interior of semiflexible chains describes elementary events in biomolecular folding and DNA bending. We calculate analytically the interior distance distribution function for semiflexible chains using…

Soft Condensed Matter · Physics 2009-11-11 Changbong Hyeon , D. Thirumalai

Electrical pacing is a common procedure that is used in both experimental and clinical settings for studying and/or annihilating anatomical reentry. In a recent study [Comtois and Vinet, Chaos 12, 903 (2002)], new ways to terminate the…

Biological Physics · Physics 2007-05-23 Philippe Comtois , Alain Vinet

We study $p$-wave superconducting quasiperiodic chains with staggered potential. The result shows a counter-intuitive phase transition phenomenon, i.e., recurrent extension phase transition (REPT). By analyzing the participation ration and…

Disordered Systems and Neural Networks · Physics 2023-10-17 Shan-Zhong Li , Zhi Li

When modelling tissue-level cardiac electrophysiology, continuum approximations to the discrete cell-level equations are used to maintain computational tractability. One of the most commonly used models is represented by the bidomain…

Computational Engineering, Finance, and Science · Computer Science 2012-08-22 Doug Bruce , Pras Pathmanathan , Jonathan P. Whiteley

Re-entry of travelling excitation loops is a long-suspected driver of human seizures, yet how such loops arise in patient brain networks -- and how susceptible they are to targeted disruption -- remains unclear. We reconstruct a…

Neurons and Cognition · Quantitative Biology 2025-08-08 Paul Triebkorn , Huifang E. Wang , Marmaduke Woodman , Maxime Guye , Fabrice Bartolomei , Viktor Jirsa

We generalize the Cable Model to describe the transport characteristics of the gap junctions coupling adjacent cells in the heart muscle. Our model takes into account recent experimental information about the time dependence of the…

Pattern Formation and Solitons · Physics 2018-09-05 Isabel M. Irurzun , Magdalena M. Defeo

We aim to assess the effectiveness of feedback controlled resonant drift pacing as a method for low energy defibrillation. Antitachycardia pacing is the only low energy defibrillation approach to have gained clinical significance, but it is…

Tissues and Organs · Quantitative Biology 2009-11-13 S. W. Morgan , G. Plank , I. V. Biktasheva , V. N. Biktashev

Cardiac re-entry regime of self-organised abnormal synchronisation underlie dangerous arrhythmias and fatal fibrillation. Recent advances in the theory of dissipative vortices, experimental studies, and anatomically realistic computer…

Reentrant computation-recursive self-coupling in which a network continuously reinjects and reinterprets its own internal state-plays a central role in biological cognition but remains poorly characterized in neural network architectures.…

Computational Physics · Physics 2025-12-23 Byung Gyu Chae

For one-dimensional random Schr\"odinger operators, the integrated density of states is known to be given in terms of the (averaged) rotation number of the Pr\"ufer phase dynamics. This paper develops a controlled perturbation theory for…

Mathematical Physics · Physics 2020-06-24 Florian Dorsch , Hermann Schulz-Baldes

We consider invertible discrete-time dynamical systems having a hyperbolic product structure in some region of the phase space with infinitely many branches and variable recurrence time. We show that the decay of correlations of the SRB…

Dynamical Systems · Mathematics 2007-05-23 Jose F. Alves , Vilton Pinheiro

We theoretically study how the dynamics of the resistive state in narrow superconducting channels shunted by an external resistor depends on channel's length $L$, the applied current $j$, and parameter $u$ characterizing the penetration…

Superconductivity · Physics 2015-06-15 V. V. Baranov , A. G. Balanov , V. V. Kabanov

Cell monolayers and epithelial tissues display slow dynamics during the liquid-glass transitions, a phenomenon with direct relevance to embryogenesis, tumor metastases, and wound healing. In active cells, persistent motion and cell…

Soft Condensed Matter · Physics 2024-01-25 Meng-Yuan Li , Yan-Wei Li

Storage and retrieval of the genetic information in cells is a dynamic process that requires the DNA to undergo dramatic structural rearrangements. DNA looping is a prominent example of such a structural rearrangement that is essential for…

Biological Physics · Physics 2015-01-07 Yi-Ju Chen , Stephanie Johnson , Peter Mulligan , Andrew J. Spakowitz , Rob Phillips

Internal recirculation in a moving droplet plays an important role in several droplet-based microfluidic devices as it enhances mixing, chemical reaction and heat transfer. The occurrence of fluid slip at the wall, which becomes prominent…

Fluid Dynamics · Physics 2013-11-26 Joseph J Thalakkottor , Kamran Mohseni

Pulse-coupled threshold units serve as paradigmatic models for a wide range of complex systems. When the state variable of a unit crosses a threshold, the unit sends a pulse that is received by other units, thereby mediating the…

Dynamical Systems · Mathematics 2010-06-04 Christoph Kirst , Marc Timme
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