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Single-molecule transistors provide a unique experimental tool to investigate the coupling between charge transport and the molecular degrees of freedom in individual molecules. One interesting class of molecules for such experiments are…

We suggest a novel approach for probing of local fluctuations of the refractive index $n$ in solids by means of single-molecule (SM) spectroscopy. It is based on the dependence $T_1(n)$ of the effective radiative lifetime $T_1$ of dye…

Optics · Physics 2015-02-18 T. A. Anikushina , M. G. Gladush , A. A. Gorshelev , A. V. Naumov

We employ heterodyne interferometry to investigate the effect of a single organic molecule on the phase of a propagating laser beam. We report on the first phase-contrast images of individual molecules and demonstrate a single-molecule…

Quantum Physics · Physics 2015-05-27 M. Pototschnig , Y. Chassagneux , J. Hwang , G. Zumofen , A. Renn , V. Sandoghdar

Single molecule spectroscopy aims at unveiling often hidden but potentially very important contributions of single entities to a system's ensemble response. Albeit contributing tremendously to our ever growing understanding of molecular…

Chemical Physics · Physics 2017-12-19 Matz Liebel , Costanza Toninelli , Niek F. van Hulst

We investigate theoretically how single-molecule spectroscopy techniques can be used to perform fast and high resolution displacement detection and manipulation of nanomechanical oscillators, such as singly clamped carbon nanotubes. We…

Mesoscale and Nanoscale Physics · Physics 2015-10-21 Vadim Puller , Brahim Lounis , Fabio Pistolesi

We discuss implications of a recent experimental breakthrough which uses a fluorescence-doped flexible semiconducting polymer to construct a single-molecule sensor which can detect ultra-weak forces in the molecular environment, with a grey…

Soft Condensed Matter · Physics 2018-02-12 Alessio Zaccone

Single-molecule fluorescence spectroscopy is a powerful method that avoids ensemble averaging, but its temporal resolution is limited by the fluorescence lifetime to nanoseconds at most. At the ensemble level, two-dimensional spectroscopy…

Optics · Physics 2024-10-11 Sanchayeeta Jana , Simon Durst , Markus Lippitz

The advent of single molecule optics has had a profound impact in fields ranging from biophysics to material science, photophysics, and quantum optics. However, all existing room-temperature single molecule methods have been based on…

Mesoscale and Nanoscale Physics · Physics 2010-07-22 Michele Celebrano , Philipp Kukura , Alois Renn , Vahid Sandoghdar

Tunneling spectroscopy played a central role in the experimental verification of the microscopic theory of superconductivity in the classical superconductors. Initial attempts to apply the same approach to high-temperature superconductors…

Superconductivity · Physics 2009-09-29 Oystein Fischer , Martin Kugler , Ivan Maggio-Aprile , Christophe Berthod , Christoph Renner

Spatial Fluorescence Cross Correlation Spectroscopy is a rarely investigated version of Fluorescence Correlation Spectroscopy, in which the fluorescence signals from different observation volumes are cross-correlated. In the reported…

Optics · Physics 2008-06-13 Yoann Blancquaert , Jie Gao , Jacques Derouard , Antoine Delon

Optical detection and spectroscopy of single molecules has become an indispensable tool in biological imaging and sensing. Its success is based on fluorescence of organic dye molecules under carefully engineered laser illumination. In this…

Chemical Physics · Physics 2011-01-18 Ilja Gerhardt , Lijian Mai , Antia Lamas-Linares , Christian Kurtsiefer

We discuss basics of scanning tunneling microscopy and spectroscopy (STM/S) of the superconducting state with normal and superconducting tips. We present a new method to measure the local variations in the Andreev reflection amplitude…

We present Full SMS, a multipurpose graphical user interface (GUI)-based software package for analysing single-molecule spectroscopy (SMS) data. SMS typically delivers multiparameter data -- such as fluorescence brightness, lifetime, and…

Biological Physics · Physics 2024-05-01 Joshua L. Botha , Bertus van Heerden , Tjaart P. J. Krüger

The electronic excitation of molecules triggers diverse phenomena such as luminescence and photovoltaic effects, which are the bases of various energy-converting devices. Understanding and control of the excitations at the single-molecule…

Chemical Physics · Physics 2017-07-12 Hiroshi Imada , Kuniyuki Miwa , Miyabi Imai-Imada , Shota Kawahara , Kensuke Kimura , Yousoo Kim

Vortices play a crucial role in determining the properties of superconductors as well as their applications. Therefore, characterization and manipulation of vortices, especially at the single vortex level, is of great importance. Among many…

We address the question of probing the supercurrents in superconducting (SC) samples on a local scale by performing Scanning Tunneling Spectroscopy (STS) experiments with a SC tip. In this configuration, we show that the tunneling…

Superconductivity · Physics 2009-11-11 A. Kohen , Th. Proslier , T. Cren , Y. Noat , W. Sacks , H. Berger , D. Roditchev

In relation to recent experimental data [1], we develop a theory framework for demonstrating the feasibility of detecting sharp Nuclear Magnetic Resonance (NMR) oscillations in a real time ESR data. The procedure is to follow real time…

Mesoscale and Nanoscale Physics · Physics 2025-09-04 Baruch Horovitz , Alexander Shnirman

The coupling of nanostructures with emitters opens ways for the realization of man-made subwavelength light emitting elements. In this article, we investigate the modification of fluorescence when an emitter is placed close to a…

Other Condensed Matter · Physics 2009-11-13 S. Kuehn , G. Mori , M. Agio , V. Sandoghdar

Two-dimensional electronic spectroscopy provides information on coupling and energy transfer between excited states on ultrafast timescales. Only recently, incoherent fluorescence detection has made it possible to combine this method with…

Optics · Physics 2025-05-14 Sanchayeeta Jana , Simon Durst , Lucas Ludwig , Markus Lippitz

Single-molecule pulling techniques have emerged as versatile tools for probing the noncovalent forces holding together the secondary and tertiary structure of macromolecules. They also constitute a way to study at the single-molecule level…

Biological Physics · Physics 2013-02-19 Ignacio Franco , Mark A. Ratner , George C. Schatz
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