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Immunological systems have been an abundant inspiration to contemporary computer scientists. Problem solving strategies, stemming from known immune system phenomena, have been successfully applied to challenging problems of modern computing…

Cell Behavior · Quantitative Biology 2017-05-24 Alexandre de Castro , Carlos Frederico Fronza , Domingos Alves

Synapses change on multiple timescales, ranging from milliseconds to minutes, due to a combination of both short- and long-term plasticity. Here we develop an extension of the common Generalized Linear Model to infer both short- and…

Neurons and Cognition · Quantitative Biology 2022-08-15 Ganchao Wei , Ian H. Stevenson

A human brain is capable of continual learning by nature; however the current mainstream deep neural networks suffer from a phenomenon named catastrophic forgetting (i.e., learning a new set of patterns suddenly and completely would result…

Machine Learning · Computer Science 2019-03-11 Zhenfeng Cao

We consider the problem of learning a set from random samples. We show how relevant geometric and topological properties of a set can be studied analytically using concepts from the theory of reproducing kernel Hilbert spaces. A new kind of…

Machine Learning · Statistics 2014-11-26 Ernesto De Vito , Lorenzo Rosasco , Alessandro Toigo

We propose a novel approach to model selection for simulator-based statistical models. The proposed approach defines a mixture of candidate models, and then iteratively updates the weight coefficients for those models as well as the…

Machine Learning · Statistics 2019-02-08 Takafumi Kajihara , Motonobu Kanagawa , Yuuki Nakaguchi , Kanishka Khandelwal , Kenji Fukumiziu

We revisit the classical kernel method of approximation/interpolation theory in a very specific context motivated by the desire to obtain a robust procedure to approximate discrete data sets by (super)level sets of functions that are merely…

Machine Learning · Computer Science 2022-09-14 Patrick Guidotti

Optimizing chemical molecules for desired properties lies at the core of drug development. Despite initial successes made by deep generative models and reinforcement learning methods, these methods were mostly limited by the requirement of…

Machine Learning · Computer Science 2021-12-01 Shuangjia Zheng , Ying Song , Zhang Pan , Chengtao Li , Le Song , Yuedong Yang

Kernel methods are a popular class of nonlinear predictive models in machine learning. Scalable algorithms for learning kernel models need to be iterative in nature, but convergence can be slow due to poor conditioning. Spectral…

Machine Learning · Statistics 2024-01-26 Amirhesam Abedsoltan , Parthe Pandit , Luis Rademacher , Mikhail Belkin

Many complex systems have been shown to share universal properties of organization, such as scale independence, modularity and self-similarity. We borrow tools from statistical physics in order to study structural preferential attachment…

Soft, disordered, micro-structured materials are ubiquitous in nature and industry, and are different from ordinary fluids or solids, with unusual, interesting static and flow properties. The transition from fluid to solid -at the so-called…

Soft Condensed Matter · Physics 2016-07-12 Nishant Kumar , Stefan Luding

In the fields of computation and neuroscience, much is still unknown about the underlying computations that enable key cognitive functions including learning, memory, abstraction and behavior. This paper proposes a mathematical and…

Artificial Intelligence · Computer Science 2025-01-14 Jeet Singh

Particle dynamics and multi-agent systems provide accurate dynamical models for studying and forecasting the behavior of complex interacting systems. They often take the form of a high-dimensional system of differential equations…

Machine Learning · Computer Science 2023-08-09 Yuxuan Liu , Scott G. McCalla , Hayden Schaeffer

We present a multiscale simulation framework to compute the current vs. voltage (I-V ) characteristics of metal/oxide/metal structures building the core of conductive bridging random access memory (CBRAM) cells and to shed light on their…

The interplay between coherence and system-environment interactions is at the basis of a wide range of phenomena, from quantum information processing to charge and energy transfer in molecular systems, biomolecules, and photochemical…

Quantum Physics · Physics 2025-11-30 Diego Fallas Padilla , Visal So , Abhishek Menon , Roman Zhuravel , Han Pu , Guido Pagano

We consider the model equation arising in the theory of viscoelasticity $$\partial_{tt} u-h_t(0)\Delta u -\int_{0}^\infty h_t'(s)\Delta u(t-s)d s+ f(u) = g.$$ Here, the main feature is that the memory kernel $h_t(\cdot)$ depends on time,…

Dynamical Systems · Mathematics 2016-03-24 Monica Conti , Valeria Danese , Claudio Giorgi , Vittorino Pata

For decades, conventional computers based on the von Neumann architecture have performed computation by repeatedly transferring data between their processing and their memory units, which are physically separated. As computation becomes…

Emerging Technologies · Computer Science 2018-02-07 Abu Sebastian , Tomas Tuma , Nikolaos Papandreou , Manuel Le Gallo , Lukas Kull , Thomas Parnell , Evangelos Eleftheriou

We construct the multilevel correlation kernel for the rising GUE eigenvalue process starting from a fixed initial configuration $x^{(m)}$, and show that it converges on short time scales (as quickly as $\text{polylog}(m)$) to the extended…

Probability · Mathematics 2026-05-01 Zoe Himwich

Lengthening a computer memory's lifespan is important for e-waste and sustainability. Uneven wear of memory is a major barrier. The problem is becoming even more urgent as emerging memory such as phase-change memory is subject to even…

Hardware Architecture · Computer Science 2026-01-29 Elizabeth Shen , Huiyang Zhou

Competition between synapses arises in some forms of correlation-based plasticity. Here we propose a game theory-inspired model of synaptic interactions whose dynamics is driven by competition between synapses in their weak and strong…

Disordered Systems and Neural Networks · Physics 2011-10-19 Ajaz Ahmad Bhat , Gaurang Mahajan , Anita Mehta

Recent developments in system identification have brought attention to regularized kernel-based methods, where, adopting the recently introduced stable spline kernel, prior information on the unknown process is enforced. This reduces the…

Systems and Control · Computer Science 2016-05-20 Riccardo Sven Risuleo , Giulio Bottegal , Håkan Hjalmarsson