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We investigate the influence of varying confinement on the dynamics of polymer translocation through a cone shaped channel. For this, a linear polymer chain is modeled by a self voiding walks (SAWs) on a square lattice. The cis-side of a…

Soft Condensed Matter · Physics 2024-01-10 Manish Dwivedi , Sumitra Rudra , Sanjay Kumar

Most of the theoretical models describing the translocation of a polymer chain through a nanopore use the hypothesis that the polymer is always relaxed during the complete process. In other words, models generally assume that the…

Biomolecules · Quantitative Biology 2009-11-13 Michel G. Gauthier , Gary W. Slater

The translocation time of a polymer chain through an interaction energy gradient nanopore was studied by Monte Carlo simulations and the Fokker-Planck equation with double-absorbing boundary conditions. Both the simulation and calculation…

Soft Condensed Matter · Physics 2017-01-04 Meng-Bo Luo , Shuang Zhang , Fan Wu , Li-Zhen Sun

We consider the dynamics of polymer translocation out of confined environments. Analytic scaling arguments lead to the prediction that the translocation time scales like $\tau\sim N^{\beta+\nu_{2D}}R^{1+(1-\nu_{2D})/\nu}$ for translocation…

Soft Condensed Matter · Physics 2009-08-11 Kaifu Luo , Ralf Metzler , Tapio Ala-Nissila , See-Chen Ying

Using Langevin dynamics simulations, we investigate the dynamics of a flexible polymer translocation into a confined area under a driving force through a nanopore. We choose an ellipsoidal shape for the confinement and consider the…

Soft Condensed Matter · Physics 2012-12-06 Kehong Zhang , Kaifu Luo

We analyze static properties of a strongly confined semiflexible polymer, i.e. either trapped in a closed space or compressed by external forces, in an athermal solvent. Like a flexible polymer case, we can resort to an analogy with the…

Soft Condensed Matter · Physics 2009-11-13 Takahiro Sakaue

We present results from our simulations of biopolymer translocation in a solvent which explain the main experimental findings. The forced translocation can be described by simple force balance arguments for the relevant range of pore…

Biological Physics · Physics 2009-05-08 V. V. Lehtola , R. P. Linna , K. Kaski

Living organisms employ diverse strategies to navigate confined environments. Inspired by translocation observations on California blackworms (\textit{Lumbriculus variegatus}), we combine biological experiments and active-polymer…

Soft Condensed Matter · Physics 2025-10-21 K. R. Prathyusha , Paulami Sarkar , Justin Xu , Saad Bhamla

We show the presence of both a minimum and clear oscillations in the frequency dependence of the translocation time of a polymer described as a unidimensional Rouse chain driven by a spatially localized oscillating linear potential. The…

Soft Condensed Matter · Physics 2010-09-16 Alessandro Fiasconaro , Juan José Mazo , Fernando Falo

We construct a new statistical physical model of polymer translocation through a pore in a membrane treated as the diffusion process across a free energy barrier. We determine the translocation time in terms of chain flexibility yielding an…

Soft Condensed Matter · Physics 2015-06-25 W. Sung , P. J. Park

Understanding and computing the entropic forces exerted by polymer chains under confinement is important for many reasons, from research to applications. However, extracting properties related to the free energy, such as the force (or…

Soft Condensed Matter · Physics 2025-07-08 Marcio S. Gomes-Filho , Eugene M. Terentjev

We consider the passage of long polymers of length N through a hole in a membrane. If the process is slow, it is in principle possible to focus on the dynamics of the number of monomers s on one side of the membrane, assuming that the two…

Soft Condensed Matter · Physics 2009-11-10 Yacov Kantor , Mehran Kardar

We report extensive simulations of the relaxation dynamics of a self-avoiding polymer confined inside a cylindrical pore. In particular, we concentrate on examining how confinement influences the scaling behavior of the global relaxation…

Soft Condensed Matter · Physics 2009-11-13 A. Arnold , B. Bozorgui , D. Frenkel , B. -Y. Ha , S. Jun

We study the translocation of a flexible polymer through extended patterned pores using molecular dynamics (MD) simulations. We consider cylindrical and conical pore geometries that can be controlled by the angle of the pore apex $\alpha$.…

Soft Condensed Matter · Physics 2026-02-11 Andri Sharma , Abhishek Chaudhuri , Rajeev Kapri

We suggest a theoretical description of the force-induced translocation dynamics of a polymer chain through a nanopore. Our consideration is based on the tensile (Pincus) blob picture of a pulled chain and the notion of propagating front of…

Soft Condensed Matter · Physics 2012-04-17 J. L. A. Dubbeldam , V. G. Rostiashvili , A. Milchev , T. A. Vilgis

Using Langevin dynamics simulations in three dimensions (3D), we investigate the dynamics of polymer translocation into the regions between two parallel plane walls with separation $R$ under a driving force $F$, respectively. Compared with…

Soft Condensed Matter · Physics 2010-08-18 Kaifu Luo , Ralf Metzler

The translocation of biopolymers, such as DNA and proteins, across cellular or nuclear membranes is essential for numerous biological processes. The translocation dynamics are influenced by the properties of the polymers, such as polymer…

Soft Condensed Matter · Physics 2024-07-29 Gokul Upadhyay , Rajeev Kapri , Anil Kumar Dasanna , Abhishek Chaudhuri

We discuss multiscale simulations of long biopolymer translocation through wide nanopores that can accommodate multiple polymer strands. The simulations provide clear evidence of folding quantization, namely, the translocation proceeds…

Biological Physics · Physics 2009-11-13 Simone Melchionna , Massimo Bernaschi , Maria Fyta , Efthimios Kaxiras , Sauro Succi

We investigate several scaling properties of a translocating homopolymer through a thin pore driven by an external field present inside the pore only using Langevin Dynamics (LD) simulation in three dimension (3D). Specifically motivated by…

We examine the ejection of an initially strongly confined flexible polymer from a spherical capsid through a nanoscale pore. We use molecular dynamics for unprecedentedly high initial monomer densities. We show that the time for an…

Biological Physics · Physics 2016-01-06 J. Piili , R. P. Linna
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