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For navigation, microscopic agents such as biological cells rely on noisy sensory input. In cells performing chemotaxis, such noise arises from the stochastic binding of signaling molecules at low concentrations. Using chemotaxis of sperm…

Biological Physics · Physics 2018-07-04 Justus A. Kromer , Steffen Märcker , Steffen Lange , Christel Baier , Benjamin M. Friedrich

The article compares traditional coefficients of thermodynamic activity as a parameter related to individual chemical species to newly introduced reduced chaotic temperatures as system characteristics, both regarding their usage in…

Chemical Physics · Physics 2007-05-23 B. Zilbergleyt

A simple coupled oscillator system with chemotaxis is introduced to study morphogenesis of cellular slime molds. The model successfuly explains the migration of pseudoplasmodium which has been experimentally predicted to be lead by cells…

adap-org · Physics 2009-10-30 Satoshi Sawai , Yoji Aizawa

Cells generally change their internal state to adapt to an environmental change, and accordingly evolve in response to the new conditions. This process involves phenotypic changes that occur over several different time scales, ranging from…

Populations and Evolution · Quantitative Biology 2015-02-03 Chikara Furusawa , Kunihiko Kaneko

Metabolic reactions of single-cell organisms are routinely observed to become dispensable or even incapable of carrying activity under certain circumstances. Yet, the mechanisms as well as the range of conditions and phenotypes associated…

Molecular Networks · Quantitative Biology 2009-01-21 Takashi Nishikawa , Natali Gulbahce , Adilson E. Motter

Cell migration often exhibits long-range temporal correlations and anomalous diffusion, even in the absence of external guidance cues such as chemical gradients or topographical constraints. These observations raise a fundamental question:…

Quantitative Methods · Quantitative Biology 2025-11-25 Gustavo Cornejo-Olea , Lucas Buvinic , Jerome Darbon , Radek Erban , Andrea Ravasio , Anastasios Matzavinos

Molecular search phenomena are observed in a variety of chemical and biological systems. During the search the participating particles frequently move in complex inhomogeneous environments with random transitions between different dynamic…

Statistical Mechanics · Physics 2018-11-13 Jaeoh Shin , Anatoly B. Kolomeisky

Organisms that locomote by propagating waves of body bending can maintain performance across heterogeneous environments by modifying their gait frequency $\omega$ or wavenumber $k$. We identify a unifying relationship between these…

Biological Physics · Physics 2025-10-02 Christopher J. Pierce , Daniel Irvine , Lucinda Peng , Xuefei Lu , Hang Lu , Daniel I. Goldman

We study the stochastic dynamics of a symmetric self-chemotactic particle and determine the long-time behavior of its mean squared displacement (MSD). The attractive or repulsive interaction of the particle with the chemical field that it…

Statistical Mechanics · Physics 2025-08-29 Jacopo Romano , Andrea Gambassi

Background: This study is mainly motivated by the need of understanding how the diffusion behaviour of a biomolecule (or even of a larger object) is affected by other moving macromolecules, organelles, and so on, inside a living cell,…

Biological Physics · Physics 2016-01-15 Matteo Gori , Irene Donato , Elena Floriani , Ilaria Nardecchia , Marco Pettini

We consider microscopic models of active particles whose velocities, rotational diffusivities, and tumbling rates depend on the gradient of a local field, which is either externally imposed or depends on all particle positions. Despite the…

Soft Condensed Matter · Physics 2020-11-18 Jérémy O'Byrne , Julien Tailleur

Chemical reactions can be modelled via diffusion processes conditioned to make a transition between specified molecular configurations representing the state of the system before and after the chemical reaction. In particular the model of…

Probability · Mathematics 2015-05-27 F. Pinski , A. M. Stuart , F. Theil

Cell movement, for example during embryogenesis or tumor metastasis, is a complex dynamical process resulting from an intricate interplay of multiple components of the cellular migration machinery. At first sight, the paths of migrating…

Cell Behavior · Quantitative Biology 2009-04-17 Peter Dieterich , Rainer Klages , Roland Preuss , Albrecht Schwab

The purpose of this work is the study of \textit{chemotaxis} and how to model it through the equations of Keller-Segel. \textit{Chemotaxis} is a natural process which induces the organisms to direct their movement according to certain…

Analysis of PDEs · Mathematics 2021-11-24 Alejandro Fernández-Jiménez

Physical kinetic roughening processes are well known to exhibit universal scaling of observables that fluctuate in space and time. Are there analogous dynamic scaling laws that are unique to the chemical reaction mechanisms available…

Statistical Mechanics · Physics 2022-11-17 Shrabani Mondal , Jonah S. Greenberg , Jason R. Green

Inspired by bacterial chemotaxis we propose a hydrodynamic molecular scale hunter that can swim and find its target. The system is essentially a stochastic low Reynolds swimmer with ability to move in two dimensional space and sense the…

Soft Condensed Matter · Physics 2015-05-20 Ali Najafi

Metabolic scaling is one of the most important patterns in biology. Theory explaining the 3/4-power size-scaling of biological metabolic rate does not predict the non-linear scaling observed for smaller life forms. Here we present a new…

Biological Physics · Physics 2024-03-04 Mark E. Ritchie , Christopher P. Kempes

Living systems adapt to various environmental conditions by changing their internal states. Inspired by gene expression and epigenetic modification dynamics, we herein propose a generic mechanism for adaptation by combining fast oscillatory…

Quantitative Methods · Quantitative Biology 2022-09-23 Yuuki Matsushita , Kunihiko Kaneko

Living systems regulate many aspects of their behavior through periodic oscillations of molecular concentrations, which function as `biochemical clocks.' These clocks are intrinsically subject to thermal fluctuations, so that the duration…

Biological Physics · Physics 2020-08-10 Robert Marsland , Wenping Cui , Jordan M. Horowitz

The present work was inspired by the recent developments in laboratory experiments made on chip, where culturing of multiple cell species was possible. The model is based on coupled reaction-diffusion-transport equations with chemotaxis,…

Numerical Analysis · Mathematics 2020-07-22 E. C. Braun , G. Bretti , R. Natalini