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We investigate morphologies of proliferating cellular tissue using a newly developed numerical simulation model for mechanical cell division. The model reproduces structures of simple multi-cellular organisms via simple rules for selective…

Soft Condensed Matter · Physics 2018-11-20 Pranav Madhikar , Jan Åström , Björn Baumeier , Mikko Karttunen

We consider a one dimensional elastic string as a set of massless beads interacting through springs characterized by anisotropic elastic constants. The string, driven by an external force, moves in a medium with quenched disorder. We…

Condensed Matter · Physics 2009-10-28 Hernán A. Makse , Albert-László Barabási , H. Eugene Stanley

Complex interactions between cellular systems and their surrounding extracellular matrices are emerging as important mechanical regulators of cell functions such as proliferation, motility, and cell death, and such cellular systems are…

Soft Condensed Matter · Physics 2021-04-16 Emmanuel L. C. VI M. Plan , Julia M. Yeomans , Amin Doostmohammadi

A phase field model is presented to investigate dislocation formation (coherency loss) and workhardening in two-phase binary alloys. In our model the elastic energy density is a periodic function of the shear and tetragonal strains, which…

Statistical Mechanics · Physics 2013-05-29 Akihiko Minami , Akira Onuki

It appeared recently that the underlying degree distribution of networks may play a crucial role concerning their robustness. Empiric and analytic results have been obtained, based on asymptotic and mean-field approximations. Previous work…

Statistical Mechanics · Physics 2009-08-24 Clemence Magnien , Matthieu Latapy , Jean-Loup Guillaume

Open cellular solids usually possess random microstructures that may contain a characteristic length scale, such as the cell size. This gives rise to size dependent mechanical properties where large systems behave differently from small…

Materials Science · Physics 2018-01-03 Stefan Liebenstein , Stefan Sandfeld , Michael Zaiser

Metamaterials can enable unique mechanical properties based on their geometry rather than their chemical composition. Such properties can go beyond what is possible using conventional materials. Most of the existing literature consider…

Applied Physics · Physics 2025-02-04 Mohamed Roshdy , Osama R. Bilal

Mechanical signaling plays a key role in biological processes like embryo development and cancer growth. One prominent way to probe mechanical properties of tissues is to study their response to externally applied forces. Using a…

Soft Condensed Matter · Physics 2017-04-18 D. A. Matoz-Fernandez , Elisabeth Agoritsas , Jean-Louis Barrat , Eric Bertin , Kirsten Martens

The high-pressure compaction of three dimensional granular packings is simulated using a bonded particle model (BPM) to capture linear elastic deformation. In the model, grains are represented by a collection of point particles connected by…

Soft Condensed Matter · Physics 2023-10-19 Joel T. Clemmer , Joseph M. Monti , Jeremy B. Lechman

Utilizing colloidal probe, lateral force microscopy and simultaneous confocal microscopy, combined with finite element analysis, we investigate the mechanism of static friction for a microparticle on a soft, adhesive surface. We find that…

Soft Condensed Matter · Physics 2023-04-26 Justin D. Glover , Xingwei Yang , Rong Long , Jonathan T. Pham

We investigate the weakening of elastic materials through randomly distributed circles and cracks numerically and compare the results to predictions from homogenization theories. We find a good agreement for the case of randomly oriented…

Materials Science · Physics 2015-05-13 Robert Spatschek , Clemens Gugenberger , Efim Brener

Using femtosecond pump-probe spectroscopy, we identify excitation induced dephasing as a major mechanism responsible for the breaking of the strong-coupling between excitons and photons in a semiconductor microcavity. The effects of…

We derive analytical expressions for the Young's modulus and the Poisson's ratio of the graphene nanoribbon, in which free edges are warped by the compressive edge stress. Our analytical formulas explicitly illustrate the reduction of the…

Mesoscale and Nanoscale Physics · Physics 2019-01-11 Guang-Rong Han , Jia-Sheng Sun , Jin-Wu Jiang

Cell layers eliminate unwanted cells through the extrusion process, which underlines healthy versus flawed tissue behaviors. Although several biochemical pathways have been identified, the underlying mechanical basis including the forces…

Soft Condensed Matter · Physics 2023-04-20 Siavash Monfared , Guruswami Ravichandran , Jose E. Andrade , Amin Doostmohammadi

How can dense biological tissue maintain sharp boundaries between coexisting cell populations? We explore this question within a simple vertex model for cells, focusing on the role of topology and tissue surface tension. We show that the…

Soft Condensed Matter · Physics 2018-02-07 Daniel M. Sussman , J. M. Schwarz , M. Cristina Marchetti , M. Lisa Manning

Cells in tissues can organize into a broad spectrum of structures according to their function. Drastic changes of organization, such as epithelial-mesenchymal transitions or the formation of spheroidal aggregates, are often associated…

Biological Physics · Physics 2016-12-22 Bart Smeets , Ricard Alert , Jiri Pesek , Ignacio Pagonabarraga , Herman Ramon , Romaric Vincent

The mechanical properties of cells, which influence the properties of the tissue they belong to, are controlled by various mechanisms. Bi et al. theoretically demonstrated that density-independent rigidity transition occurs in…

Soft Condensed Matter · Physics 2018-02-27 H. Nogucci

We measure the dynamical mechanical properties of human red blood cells. Single cell response is measured with optical tweezers. We investigate both the stress relaxation following a fast deformation, and the effect of varying the strain…

Soft Condensed Matter · Physics 2009-11-13 Young-Zoon Yoon , Jurij Kotar , Gilwon Yoon , Pietro Cicuta

The main result of this work is a homogenization theorem via variational convergence for elastic materials with stiff checkerboard-type heterogeneities under the assumptions of physical growth and non-self-interpenetration. While the…

Analysis of PDEs · Mathematics 2023-03-29 Wolf-Patrick Düll , Dominik Engl , Carolin Kreisbeck

We demonstrate that a key elastic parameter of a suspended crystalline membrane---the Poisson ratio (PR) $\nu$---is a non-trivial function of the applied stress $\sigma$ and of the system size $L$, i.e., $\nu=\nu_L(\sigma)$. We consider a…

Mesoscale and Nanoscale Physics · Physics 2018-05-01 I. S. Burmistrov , I. V. Gornyi V. Yu. Kachorovskii , M. I. Katsnelson , J. H. Los , A. D. Mirlin