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The principle of maximum entropy is a broadly applicable technique for computing a distribution with the least amount of information possible constrained to match empirical data, for instance, feature expectations. We seek to generalize…

Information Theory · Computer Science 2022-05-30 Kenneth Bogert

The extremization of an appropriate entropic functional may yield to the probability distribution functions maximizing the respective entropic structure. This procedure is known in Statistical Mechanics and Information Theory as Jaynes'…

Statistical Mechanics · Physics 2015-05-13 Thomas Oikonomou , Ugur Tirnakli

We demonstrate and characterize a first-principles approach to modeling the mass action dynamics of metabolism. Starting from a basic definition of entropy expressed as a multinomial probability density using Boltzmann probabilities with…

Chemical Physics · Physics 2024-07-10 William R. Cannon , Samuel Britton , Mikahl Banwarth-Kuhn , Mark Alber

A critical task in systems biology is the identification of genes that interact to control cellular processes by transcriptional activation of a set of target genes. Many methods have been developed to use statistical correlations in…

Quantitative Methods · Quantitative Biology 2010-11-24 Adam A. Margolin , Kai Wang , Andrea Califano , Ilya Nemenman

Interaction networks, consisting of agents linked by their interactions, are ubiquitous across many disciplines of modern science. Many methods of analysis of interaction networks have been proposed, mainly concentrating on node degree…

Molecular Networks · Quantitative Biology 2011-12-20 Aleksandar Stojmirović , Yi-Kuo Yu

Classical deterministic optimal control problems assume full information about the controlled process. The theory of control for general partially-observable processes is powerful, but the methods are computationally expensive and typically…

Optimization and Control · Mathematics 2024-08-02 Dongping Qi , Adam Dhillon , Alexander Vladimirsky

We define the concept of dependence among multiple variables using maximum entropy techniques and introduce a graphical notation to denote the dependencies. Direct inference of information theoretic quantities from data uncovers…

Quantitative Methods · Quantitative Biology 2007-07-13 Ilya Nemenman

In recent years, the discovery of complex dynamic systems in various fields through data-driven methods has attracted widespread attention. This method has played the role of data and has become an advantageous tool for us to study complex…

Dynamical Systems · Mathematics 2020-12-02 Min Dai , Ting Gao , Yubin Lu , Yayun Zheng , Jinqiao Duan

The set of solutions inferred by the generic maximum entropy (MaxEnt) or maximum relative entropy (MaxREnt) principles of Jaynes - considered as a function of the moment constraints or their conjugate Lagrangian multipliers - is endowed…

Statistical Mechanics · Physics 2017-08-23 Robert K. Niven , Bjarne Andresen

Path-dependent stochastic processes are often non-ergodic and observables can no longer be computed within the ensemble picture. The resulting mathematical difficulties pose severe limits to the analytical understanding of path-dependent…

Statistical Mechanics · Physics 2016-12-26 Rudolf Hanel , Bernat Corominas-Murtra , Stefan Thurner

Here we present the entropic dynamics formalism for networks. That is, a framework for the dynamics of graphs meant to represent a network derived from the principle of maximum entropy and the rate of transition is obtained taking into…

Physics and Society · Physics 2021-04-29 Felipe Xavier Costa , Pedro Pessoa

Optimization results are one method for understanding neural computation from Nature's perspective and for defining the physical limits on neuron-like engineering. Earlier work looks at individual properties or performance criteria and…

Neurons and Cognition · Quantitative Biology 2017-12-21 William B Levy , Toby Berger , Mustafa Sungkar

Within a fully microscopic setting, we derive a variational principle for the non-equilibrium steady states of chemical reaction networks, valid for time-scales over which chemical potentials can be taken to be slowly varying: at…

Molecular Networks · Quantitative Biology 2015-06-05 Andrea De Martino , Daniele De Martino , Roberto Mulet , Guido Uguzzoni

We introduce a reaction-path statistical mechanics formalism based on the principle of large deviations to quantify the kinetics of single-molecule enzymatic reaction processes under the Michaelis-Menten mechanism, which exemplifies an…

Statistical Mechanics · Physics 2022-04-11 Hyuntae Lim , YounJoon Jung

In its general definition, the law of mass action posits that, in systems where multiple elements move randomly, the rate by which they physically interact is proportional to the product of their densities. This law predicts the rate of…

Chemical Physics · Physics 2021-01-08 Jerome J. Lacroix

Extinction of an epidemic or a species is a rare event that occurs due to a large, rare stochastic fluctuation. Although the extinction process is dynamically unstable, it follows an optimal path that maximizes the probability of…

Biological Physics · Physics 2010-03-25 Eric Forgoston , Simone Bianco , Leah B. Shaw , Ira B. Schwartz

Inferring the causal direction and causal effect between two discrete random variables X and Y from a finite sample is often a crucial problem and a challenging task. However, if we have access to observational and interventional data, it…

Machine Learning · Statistics 2020-10-16 Peter Gmeiner

Maximization of the entropy rate is an important issue to design diffusion processes aiming at a well-mixed state. We demonstrate that it is possible to construct maximal-entropy random walks with only local information on the graph…

Statistical Mechanics · Physics 2011-03-14 Roberta Sinatra , Jesús Gómez-Gardeñes , Renaud Lambiotte , Vincenzo Nicosia , Vito Latora

Despite the wide usage of information as a concept in science, we have yet to develop a clear & concise scientific definition. This paper is aimed at laying the foundations for a new theory concerning the mechanics of information alongside…

General Physics · Physics 2017-07-13 Kiyam Lin , SongLing Lin

This is a general description of a probabilistic formalism of mechanics, i.e., an extension of the Newtonian mechanics principles to the systems undergoing random motion. From an analysis of the induction procedure from experimental data to…

Statistical Mechanics · Physics 2010-03-29 Qiuping A. Wang