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Upon the addition of multivalent cations, a giant DNA chain exhibits a large discrete transition from an elongated coil into a folded compact state. We performed single-chain observation of long DNAs in the presence of a tetravalent cation…

Soft Condensed Matter · Physics 2009-11-10 Takuya Saito , Takafumi Iwaki , Kenichi Yoshikawa

Phase separation in biomolecular mixtures can result from multiple physical interactions, which may act either complementarily or antagonistically. In the case of protein-nucleic acid mixtures, charge plays a key role but can have…

Soft Condensed Matter · Physics 2026-05-13 Gabrielle R. Abraham , Tianhao Li , Anna Nguyen , William M. Jacobs , Omar A. Saleh

The phase diagram of a water solution of DNA and oppositely charged spherical macroions is studied. DNA winds around spheres to form beads-on-a-string complexes resembling the chromatin 10 nm fiber. At small enough concentration of spheres…

Soft Condensed Matter · Physics 2009-11-07 Toan T. Nguyen , Boris I. Shklovskii

DNA is now firmly established as a versatile and robust platform for achieving synthetic nanostructures. While the folding of single molecules into complex structures is routinely achieved through engineering basepair sequences, much less…

Soft Condensed Matter · Physics 2025-05-15 Soumen De Karmakar , Thomas Speck

A theory of condensation and resolubilization of a dilute DNA solution with growing concentration of multivalent cations, N is suggested. It is based on a new theory of screening of a macroion by multivalent cations, which shows that due to…

Soft Condensed Matter · Physics 2009-10-31 T. T. Nguyen , I. Rouzina , B. I. Shklovskii

The high linear charge density of 20-base-pair oligomers of DNA is shown to lead to a striking non-monotonic dependence of the long-time self-diffusion on the concentration of the DNA in low-salt conditions. This generic non-monotonic…

Soft Condensed Matter · Physics 2009-11-13 M. G. McPhie , G. Naegele

We report the formation of colloidal complexes resulting from the electrostatic co-assembly between anionic surfactants and cationic polyelectrolytes or block copolymers. Combining light and x-ray scattering experiments with cryogenic…

Soft Condensed Matter · Physics 2009-04-01 J. -F. Berret

We present a model for the joint self-assembly of amphiphilic polymers and small amphiphilic molecules (surfactants) in a dilute aqueous solution. The polymer is assumed to consist of a hydrophilic backbone and a large number of hydrophobic…

Soft Condensed Matter · Physics 2007-05-23 H. Diamant , D. Andelman

The electrodynamic response of DNA in the millimeter wave range is investigated. By performing measurements under a wide range of humidity conditions and comparing the response of single strand DNA and double strand DNA, we show that the…

Disordered Systems and Neural Networks · Physics 2015-06-24 M. Briman , N. P. Armitage , E. Helgren , G. Gruner

Synchrotron-X-ray and surface tension studies of a strong polyelectrolyte (PE) in the semi-dilute regime (~ 0.1M monomer-charges) with varying surfactant concentrations show that minute surfactant concentrations induce the formation of a…

Soft Condensed Matter · Physics 2009-11-10 D. Vaknin , S. Dahlke , A. Travesset , G. Nizri , S. Magdassi

Recent experiments have shown that trivalent ion, spermidine$^{3+}$, can provoke lateral microphase segregation in DNA brushes. Using molecular simulations and simple theoretical arguments, we explore the effects of trivalent counterions on…

Soft Condensed Matter · Physics 2017-03-03 Lei Liu , Philip A. Pincus , Changbong Hyeon

In solution, DNA is a highly charged macromolecule which bears a unit of negative charge on each phosphate of its sugar-phosphate backbone. Although partially compensated by counterions adsorbed at or condensed near it, DNA still produces a…

Soft Condensed Matter · Physics 2024-03-11 Jonathan G. Hedley , Kush Coshic , Aleksei Aksimentiev , Alexei A. Kornyshev

We consider the complexation of highly charged semiflexible polyelectrolytes with oppositely charged macroions. On the basis of scaling arguments we discuss how the resulting complexes depend on the persistence length of the…

Soft Condensed Matter · Physics 2009-11-07 H. Schiessel , R. F. Bruinsma , W. M. Gelbart

We study the salt-dependent conformations of dilute flexible polyelectrolytes in solution via computer simulations. Low concentrations of multivalent salt induce the known conformational collapse of individual polyelectrolyte chains, but as…

Soft Condensed Matter · Physics 2009-11-11 Pai-Yi Hsiao , Erik Luijten

Soft matter materials, such as polymers, membranes, proteins, are often electrically charged. This makes them water soluble, which is of great importance in technological application and a prerequisite for biological function. We discuss a…

Soft Condensed Matter · Physics 2007-05-23 H. Boroudjerdi , Y. -W. Kim , A. Naji , R. R. Netz , X. Schlagberger , A. Serr

By using single-DNA observation with fluorescence microscopy, we observed the effects of divalent and trivalent cations on the higher-order structure of giant DNA (T4 DNA with 166 kbp). It was found that divalent cations, such as Mg(2+) and…

Biological Physics · Physics 2016-01-08 C. Tongu , T. Kenmotsu , Y. Yoshikawa , A. A. Zinchenko , N. Chen , K. Yoshikawa

Using the complex Langevin sampling strategy, field theoretic simulations are performed to study the equilibrium phase behavior and structure of symmetric polycation-polyanion mixtures without salt in good solvents. Static structure factors…

Soft Condensed Matter · Physics 2008-06-14 Jonghoon Lee , Yuri O. Popov , Glenn H. Fredrickson

We report measurements of turbulent drag reduction of two different polyelectrolyte solutions: DNA and hydrolyzed Polyacrylamide. Changing the salt concentration in the solutions allows us to change the flexibility of the polymer chains.…

Fluid Dynamics · Physics 2007-05-23 Christian Wagner , Yassine Amarouchene , Patrick Doyle , Daniel Bonn

We have studied a bulk electrolyte, and polyelectrolyte solutions with surfactants or multivalent salt with the explicit presence of counterions and solvent molecules by means of the mesoscopic dissipative particle dynamics (DPD) method in…

Soft Condensed Matter · Physics 2010-01-20 F. Alarcon Oseguera , E. Perez , A. Gama Goicochea

The problem of DNA-DNA interaction mediated by divalent counterions is studied using computer simulation. Although divalent counterions cannot condense free DNA molecules in solution, we show that if DNA configurational entropy is…

Biomolecules · Quantitative Biology 2011-03-29 SeIl Lee , Tung T Le , Toan T Nguyen