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Hydrophobic thickness mismatch between integral membrane proteins and the surrounding lipid bilayer can produce lipid bilayer thickness deformations. Experiment and theory have shown that protein-induced lipid bilayer thickness deformations…

Biomolecules · Quantitative Biology 2016-11-04 Osman Kahraman , Peter D. Koch , William S. Klug , Christoph A. Haselwandter

The low sliding friction of articular cartilage in the major joints , which is crucial for its homeostasis and for joint health, has been attributed to lipid bilayers forming lubricious boundary layers at its surface. The robustness of such…

Soft Condensed Matter · Physics 2023-09-06 Salome Mielke , Raya Sorkin , Jacob Klein

The study of the structural behaviour of pure and multi-component lipids at various temperatures and the interaction of these multi-component lipids with pharmaceutically important drugs carry huge importance. Here, we investigated the…

Soft Condensed Matter · Physics 2021-03-26 Prantar Dutta , Debabrata Pramanik , Jayant K. Singh

We present a simple and computationally efficient coarse-grained and solvent-free model for simulating lipid bilayer membranes. In order to be used in concert with particle-based reaction-diffusion simulations, the model is purely based on…

Biological Physics · Physics 2018-01-31 Mohsen Sadeghi , Thomas R. Weikl , Frank Noé

We propose a robust platform for simulating chiral quantum magnetism using linear arrays of trapped asymmetric top molecules, specifically 1,2-propanediol ($\mathrm{C_{3}H_{8}O_{2}}$). By mapping the Stark-dressed rotational states onto an…

Quantum Physics · Physics 2026-02-11 Muhammad Arsalan Ali Akbar , Bretislav Friedrich , Sabre Kais

The biological function of membranes is closely related to their softness, which is often studied through the membranes' thermally-driven fluctuations. The analysis commonly assumes that the relaxation rate of a pure bending deformation is…

Soft Condensed Matter · Physics 2024-07-09 Hammad A. Faizi , Rony Granek , Petia M. Vlahovska

Highly oriented solid-supported lipid membranes in stacks of controlled number $N \simeq 16$ (oligo-membranes) have been prepared by spin-coating using the uncharged lipid model system 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC). The…

Soft Condensed Matter · Physics 2015-04-10 Ulrike Mennicke , Doru Constantin , Tim Salditt

The activation kinetics of the ion channels formed by colicin Ia incorporated into a planar bilayer lipid membrane (BLM) was investigated by the voltage clamp technique using different step voltage stimuli. The temporal behaviour of ion…

Biological Physics · Physics 2007-05-23 R. Cassia-Moura , A. Popescu

The interpretation electrical phenomena in biomembranes is usually based on the assumption that the experimentally found discrete ion conduction events are due to a particular class of proteins called ion channels while the lipid membrane…

Biological Physics · Physics 2010-06-17 Thomas Heimburg

A swollen phase, in which the mean repeat distance of lipid bilayers is larger than the other phases, is found between the liquid-crystalline phase and the interdigitated gel phase in DPPC aqueous solution. Temperature, pressure and ethanol…

Soft Condensed Matter · Physics 2009-03-13 H. Seto , M. Hishida , H. Nobutou , N. L. Yamada , M. Nagao , T. Takeda

Membrane phase-separation is a mechanism that biological membranes often use to locally concentrate specific lipid species in order to organize diverse membrane processes. Phase separation has also been explored as a tool for the design of…

Computational Physics · Physics 2020-06-26 Alexander Zhiliakov , Yifei Wang , Annalisa Quaini , Maxim Olshanskii , Sheereen Majd

A variety of models for the membrane-mediated interaction of particles in lipid membranes, mostly well-established in theoretical physics, is reviewed from a mathematical perspective. We provide mathematically consistent formulations in a…

Analysis of PDEs · Mathematics 2016-06-29 Charles M. Elliott , Carsten Gräser , Graham Hobbs , Ralf Kornhuber , Maren-Wanda Wolf

The rapid emergence of multidrug-resistant (MDR) bacteria demands development of novel and effective antimicrobial agents. Structurally Nanoengineered Antimicrobial Peptide Polymers (SNAPPs), characterized by their unique star-shaped…

Biological Physics · Physics 2025-05-13 Amal Jayawardena , Andrew Hung , Greg Qiao , Elnaz Hajizadeh

The phase behaviour and dynamics of molecular ionic liquids are studied using primitive models and extensive computer simulations. The models account for size disparity between cation and anion, charge location on the cation, and…

Soft Condensed Matter · Physics 2012-02-23 G. C. Ganzenmüller , P. J. Camp

Active matter describes materials whose constituents are driven out of equilibrium by continuous energy consumption, for instance from ATP. Due to the orientable character of the constituents, active suspensions can attain liquid…

Soft Condensed Matter · Physics 2020-11-03 L. N. Carenza , G. Gonnella , G. Negro

Polyacrylonitrile (PAN) is an important commercial polymer, bearing atactic stereochemistry resulting from nonselective radical polymerization. As such, an accurate, fundamental understanding of governing interactions among PAN molecular…

We implement the replica exchange molecular dynamics algorithm to study the interactions of a model peptide (WALP-16) with an explicitly represented DPPC membrane bilayer. We observe the spontaneous, unbiased insertion of WALP-16 into the…

Biomolecules · Quantitative Biology 2007-05-23 Hugh Nymeyer , Thomas B. Woolf , Angel E. Garcia

A great variety of biologically relevant monolayers present phase coexistence characterized by domains formed by lipids in an ordered phase state dispersed in a continuous, disordered phase. The difference in surface densities between these…

Biological Physics · Physics 2018-02-19 Elena Rufeil Fiori , Natalia Wilke , Adolfo J. Banchio

We propose a very simple but realistic enough model which allows to include a large number of molecules in molecular dynamics MD simulations of these bilayers, but nevertheless taking into account molecular charge distributions, flexible…

Soft Condensed Matter · Physics 2009-11-13 Z. Gamba

We present a model for the efficient simulation of generic bilayer membranes. Individual lipids are represented by one head- and two tail-beads. By means of simple pair potentials these robustly self-assemble to a fluid bilayer state over a…

Soft Condensed Matter · Physics 2009-11-11 Ira R. Cooke , Kurt Kremer , Markus Deserno