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Place cells in the hippocampus are active when an animal visits a certain location (referred to as a place field) within an environment. Grid cells in the medial entorhinal cortex (MEC) respond at multiple locations, with firing fields that…

Neurons and Cognition · Quantitative Biology 2018-05-17 David M. Schwartz , O. Ozan Koyluoglu

It is widely accepted that the hippocampal place cells' spiking activity produces a cognitive map of space. However, many details of this representation's physiological mechanism remain unknown. For example, it is believed that the place…

Neurons and Cognition · Quantitative Biology 2015-09-08 A. Babichev , D. Ji , F. Memoli , Y. Dabaghian

High-dimensional neural activity often reside in a low-dimensional subspace, referred to as neural manifolds. Grid cells in the medial entorhinal cortex provide a periodic spatial code that are organized near a toroidal manifold,…

Neurons and Cognition · Quantitative Biology 2025-10-22 Yuxing Jared Yao , Iris H. R. Yoon

Many real-world complex systems including human interactions can be represented by temporal (or evolving) networks, where links activate or deactivate over time. Characterizing temporal networks is crucial to compare such systems and to…

Physics and Society · Physics 2022-08-30 Alberto Ceria , Shlomo Havlin , Alan Hanjalic , Huijuan Wang

Functional connectivity is a fundamental property of neural networks that quantifies the segregation and integration of information between cortical areas. Due to mathematical complexity, a theory that could explain how the parameters of…

Neurons and Cognition · Quantitative Biology 2016-05-27 Diego Fasoli , Anna Cattani , Stefano Panzeri

Existing studies have demonstrated significant sex differences in the neural mechanisms of daily life and neuropsychiatric disorders. The hierarchical organization of the functional brain network is a critical feature for assessing these…

Neurons and Cognition · Quantitative Biology 2024-09-25 Wenyu Chen , Ling Zhan , Tao Jia

Modeling the behavior of coupled networks is challenging due to their intricate dynamics. For example in neuroscience, it is of critical importance to understand the relationship between the functional neural processes and anatomical…

Machine Learning · Computer Science 2021-04-20 Hongyuan You , Sikun Lin , Ambuj K. Singh

The human brain possesses the extraordinary capability to contextualize the information it receives from our environment. The entorhinal-hippocampal plays a critical role in this function, as it is deeply engaged in memory processing and…

Artificial Intelligence · Computer Science 2023-07-06 Paul Stoewer , Achim Schilling , Andreas Maier , Patrick Krauss

Computational models are an essential tool for understanding the origin and functions of the topographic organisation of the primate visual system. Yet, vision is most commonly modelled by convolutional neural networks that ignore…

Neurons and Cognition · Quantitative Biology 2023-08-21 Zejin Lu , Adrien Doerig , Victoria Bosch , Bas Krahmer , Daniel Kaiser , Radoslaw M Cichy , Tim C Kietzmann

Biological systems, from a cell to the human brain, are inherently complex. A powerful representation of such systems, described by an intricate web of relationships across multiple scales, is provided by complex networks. Recently, several…

Quantitative Methods · Quantitative Biology 2018-02-06 M. De Domenico

One of the biggest challenges in biology is to understand how activity at the cellular level of neurons, as a result of their mutual interactions, leads to the observed behavior of an organism responding to a variety of environmental…

Neurons and Cognition · Quantitative Biology 2010-03-09 Raj Kumar Pan , Nivedita Chatterjee , Sitabhra Sinha

Neurons in the brain are organized such that nearby cells tend to share similar functions. AI models lack this organization, and past efforts to introduce topography have often led to trade-offs between topography and task performance. In…

Machine Learning · Computer Science 2025-01-29 Mayukh Deb , Mainak Deb , N. Apurva Ratan Murty

Temporal networks are widely used models for describing the architecture of complex systems. Network memory -- that is the dependence of a temporal network's structure on its past -- has been shown to play a prominent role in diffusion,…

Physics and Society · Physics 2020-04-28 Oliver E. Williams , Lucas Lacasa , Ana P. Millán , Vito Latora

In recent years, there has been increasing interest in developing models and tools to address the complex patterns of connectivity found in brain tissue. Specifically, this is due to a need to understand how emergent properties emerge from…

Neurons and Cognition · Quantitative Biology 2022-04-15 Sean Knight , Navjot Gadda

Anatomical connectivity imposes strong constraints on brain function, but there is no general agreement about principles that govern its organization. Based on extensive quantitative data we tested the power of three models to predict…

Neurons and Cognition · Quantitative Biology 2016-05-31 Sarah F. Beul , Helen Barbas , Claus C. Hilgetag

Biological neural networks exist in physical space where distance influences communication delays: a fundamental coupling between space and time absent in most artificial neural networks. While recent work has separately explored spatial…

Neural and Evolutionary Computing · Computer Science 2026-01-27 Balázs Mészáros , James C. Knight , Danyal Akarca , Thomas Nowotny

The brain is a paradigmatic example of a complex system as its functionality emerges as a global property of local mesoscopic and microscopic interactions. Complex network theory allows to elicit the functional architecture of the brain in…

Neurons and Cognition · Quantitative Biology 2017-01-18 Rossana Mastrandrea , Andrea Gabrielli , Fabrizio Piras , Gianfranco Spalletta , Guido Caldarelli , Tommaso Gili

The study of dynamical systems defined on complex networks provides a natural framework with which to investigate myriad features of neural dynamics, and has been widely undertaken. Typically, however, networks employed in theoretical…

Neurons and Cognition · Quantitative Biology 2013-02-22 Reuben O'Dea , Jonathan J. Crofts , Marcus Kaiser

Complex networks encountered in biology are often characterized by significant structural diversity. Whether it be differences in the three-dimensional structure of allosteric proteins, or the variation among the micro-scale structures of…

Physics and Society · Physics 2020-08-19 Jason W. Rocks , Andrea J. Liu , Eleni Katifori

Trophic coherence, a measure of the extent to which the nodes of a directed network are organised in levels, has recently been shown to be closely related to many structural and dynamical aspects of complex systems, including graph…

Physics and Society · Physics 2016-07-22 Janis Klaise , Samuel Johnson