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Biological membranes mainly consist of lipids and proteins. While the proteins have many functions as single molecules, the membrane as a whole displays physical properties that cannot be explained on the single molecule level. For example,…

Biological Physics · Physics 2009-06-09 Thomas Heimburg

Gaining access to the cell interior is fundamental for many applications, such as electrical recording, drug and biomolecular delivery. A very promising technique consists of culturing cells on nano/micro pillars. The tight adhesion and…

The adhesion bonds connecting a lipid bilayer to an underlying surface may undergo a condensation transition resulting from an interplay between a short range attractive potential between them, and a long range fluctuation-induced potential…

Soft Condensed Matter · Physics 2016-02-25 Nadiv Dharan , Oded Farago

We numerically investigate the effects of fiber aspect ratio, roughness, flexibility, and flow inertia on the rheology of concentrated suspensions. We perform direct numerical simulations modeling the fibers, suspended in an incompressible…

Fluid Dynamics · Physics 2025-01-23 Monsurul Khan , Rishabh V. More , Arash Alizad Banaei , Luca Brandt , Arezoo M. Ardekani

Spatial organisation is a hallmark of all living cells, and recreating it in model systems is a necessary step in the creation of synthetic cells. It is therefore of both fundamental and practical interest to better understand the basic…

Biological Physics · Physics 2017-12-19 Jaime Agudo-Canalejo , Ramin Golestanian

We extend the Saffman theory of membrane hydrodynamics to account for the correlated motion of membrane proteins, along with the effect of protein concentration on that correlation and on the response of the membrane to stresses.…

Soft Condensed Matter · Physics 2015-05-13 Naomi Oppenheimer , Haim Diamant

Rigidity transitions in simple models of confluent cells have been a powerful organizing principle in understanding the dynamics and mechanics of dense biological tissue. In this work we explore the interplay between geometry and rigidity…

Soft Condensed Matter · Physics 2020-07-08 Daniel M. Sussman

Elucidating the physics of a concentrated suspension of ring polymers, or of an ensemble of ring polymers in a complex environment, is an important outstanding question in polymer physics. Many of the characteristic features of these…

Soft Condensed Matter · Physics 2017-08-09 Davide Michieletto , Enzo Orlandini , Davide Marenduzzo , Matthew S. Turner

Bin/Amphiphysin/Rvs superfamily proteins and other curvature-inducing proteins have anisotropic shapes and anisotropically bend biomembrane. Here, we report how the anisotropic proteins bind the membrane tube and are orientationally ordered…

Soft Condensed Matter · Physics 2022-05-09 Hiroshi Noguchi , Caterina Tozzi , Marino Arroyo

The entropic effects of anchored polymers on biomembranes are studied using simulations of a meshless membrane model combined with anchored linear polymer chains. The bending rigidity and spontaneous curvature are investigated for anchored…

Soft Condensed Matter · Physics 2015-02-18 Hao Wu , Hayato Shiba , Hiroshi Noguchi

Within a general framework we study the effective, deformation-induced interaction between two colloids trapped at a fluid interface. As an application, we consider the interface deformation owing to the electrostatic field of charged…

Soft Condensed Matter · Physics 2007-05-23 Alvaro Dominguez , Martin Oettel , Siegfried Dietrich

The adhesion of biological membranes is controlled by various types of receptor and ligand molecules. In this letter, we present a statistical-mechanical model for membranes that interact via receptor/ligand bonds of two different lengths.…

Soft Condensed Matter · Physics 2009-11-11 Mesfin Asfaw , Bartosz Rozycki , Reinhard Lipowsky , Thomas R. Weikl

Symmetry is closely intertwined with the function, genetics, and chemical properties of multiprotein complexes. Here, we explore the relation between structural symmetry and the ability of membrane proteins to sense and induce membrane…

Biological Physics · Physics 2018-10-19 Federico Elías-Wolff , Alexander Lyubartsev , Erik G. Brandt , Martin Lindén

In a system of colloidal inclusions suspended in a thermalized bath of smaller particles, the bath engenders an attractive force between the inclusions, arising mainly from entropic origins, known as the depletion force. In the case of…

Soft Condensed Matter · Physics 2020-10-01 Mahdi Zarif , Ali Naji

Adsorption of proteins onto membranes can alter the local membrane curvature. This phenomenon has been observed in biological processes such as endocytosis, tubulation and vesiculation. However, it is not clear how the local surface…

Cell Behavior · Quantitative Biology 2016-04-28 Padmini Rangamani , Kranthi Kiran Mandadapu , George Oster

We use scaling arguments and coarse grained Monte Carlo simulations to study the fluctuation mediated interactions between a pair of adhesion sites of a bilayer membrane and a supporting surface. We find that the potential of mean force is…

Soft Condensed Matter · Physics 2015-05-18 Oded Farago

Conical inclusions in a lipid bilayer generate an overall spontaneous curvature of the membrane that depends on concentration and geometry of the inclusions. Examples are integral and attached membrane proteins, viruses, and lipid domains.…

Soft Condensed Matter · Physics 2009-10-19 Thorsten Auth , Gerhard Gompper

Hydrophobic interactions provide driving forces for protein folding, membrane formation, and oil-water separation. Motivated by information theory, the poorly understood nonpolar solute interactions in water are investigated. A simple…

chem-ph · Physics 2008-02-03 G. Hummer , S. Garde , A. E. Garcia , A. Pohorille , L. R. Pratt

We consider a dilute solution of infinitely rigid rods near a curved, perfectly repulsive surface and study the contribution of the rod depletion layer to the bending elastic constants of membranes. We find that a spontaneous curvature…

Materials Science · Physics 2009-10-28 K. Yaman , P. Pincus , C. M. Marques

A cell membrane can be simply regarded as composite material consisting of lipid bilayer, membrane cytoskeleton beneath lipid bilayer, and proteins embedded in lipid bilayer and linked with membrane cytoskeleton if one only concerns its…

Other Quantitative Biology · Quantitative Biology 2007-06-26 Z. C. Tu , R. An , Z. C. Ou-Yang
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