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We study membrane-protein interactions and membrane-mediated protein-protein interactions by Monte Carlo simulations of a generic coarse-grained model for lipid bilayers with cylindrical hydrophobic inclusions. The strength of the…

Biological Physics · Physics 2009-11-13 Beate West , Frank L. H. Brown , Friederike Schmid

The excimer formation dynamics of pyrene-labeled molecules in lipid bilayers depends on molecular motion over distances of the order of 1-2 nm. From the concentration dependence of the excimer photoemission curve, it is possible to derive a…

Soft Condensed Matter · Physics 2022-04-12 Pierre Ayoub , Fabrice Thalmann

This study focuses on comparing the individual polymer chain dynamics in an entangled polymeric liquid under different shear and extension rates. Polymer chains under various shear rates and extension rates were simulated using a…

Chemical Physics · Physics 2021-01-15 Behrouz Behdani , Tong Mou , Cody Spratt , Slava Butcovich , Ryan Gettler , Joontaek Park

Biological membranes are elastic media in which the presence of a transmembrane protein leads to local bilayer deformation. The energetics of deformation allow two membrane proteins in close proximity to influence each other's equilibrium…

Subcellular Processes · Quantitative Biology 2015-06-26 Tristan Ursell , Kerwyn Huang , Eric Peterson , Rob Phillips

The supramolecular assembly of lipids into bilayer membranes is essential for cellular structure and function. However, the impact of lipid structural variations such as acyl chain length, degree of unsaturation, and headgroup type on…

Soft Condensed Matter · Physics 2024-12-13 Sonam Phuntsho

Temperature controlled Polarization Modulation Near-Field Scanning Optical Microscopy (PM-NSOM) measurements of a single supported $L_{\beta^{\prime}}$ 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) lipid bilayer are presented. The…

Soft Condensed Matter · Physics 2020-04-01 Merrell A. Johnson , Ricardo S. Decca

Biomembranes, which are mainly composed of neutral and charged lipids, exhibit a large variety of functional structures and dynamics. Here, we report a coarse-grained molecular dynamics (MD) simulation of the phase separation and…

Soft Condensed Matter · Physics 2016-11-07 Hiroaki Ito , Yuji Higuchi , Naofumi Shimokawa

Hydrophobic thickness mismatch between integral membrane proteins and the surrounding lipid bilayer can produce lipid bilayer thickness deformations. Experiment and theory have shown that protein-induced lipid bilayer thickness deformations…

Biomolecules · Quantitative Biology 2016-11-04 Osman Kahraman , Peter D. Koch , William S. Klug , Christoph A. Haselwandter

Equilibration dynamics of hot oxygen atoms following O2 dissociation on Pd(100) and Pd(111) surfaces are investigated by molecular dynamics simulations based on a scalable neural network potential enabling first-principles description of O2…

Materials Science · Physics 2023-04-24 Qidong Lin , Bin Jiang

Water-phospholipid interactions at the lipid bilayer/water interfaces are of essential importance for the dynamics, stability and function of biological membrane, and are also strongly associated with numerous biological processes at the…

Soft Condensed Matter · Physics 2018-01-04 Jianjun Jiang , Weixin Li , Liang Zhao , Yuanyan Wu , Peng Xiu , Guoning Tang , Yusong Tu

Creating crystal bilayers twisted with respect to each other would lead to large periodic supercell structures, which can support a wide range of novel electron correlated phenomena, where the full understanding is still under debate. Here,…

Quantum Gases · Physics 2024-08-01 Rui Tian , Yue Zhang , Tianhao Wu , Min Liu , Yong-Chang Zhang , Shuai Li , Bo Liu

We report a high energy-resolution neutron backscattering study to investigate slow motions on nanosecond time scales in highly oriented solid supported phospholipid bilayers of the model system DMPC -d54 (deuterated…

Soft Condensed Matter · Physics 2007-05-23 Maikel C. Rheinstädter , Tilo Seydel , Franz Demmel , Tim Salditt

A mesoscopic coarse-grain model for computationally-efficient simulations of biomembranes is presented. It combines molecular dynamics simulations for the lipids, modeled as elastic chains of beads, with multiparticle collision dynamics for…

Soft Condensed Matter · Physics 2015-06-04 Mu-Jie Huang , Raymond Kapral , Alexander S. Mikhailov , Hsuan-Yi Chen

We investigate the mechanical properties of bilayers of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine in the gel phase by using peak force tapping with quantitative nanomechanical mapping. We study both dry and aqueous bilayers and liposomes…

Soft Condensed Matter · Physics 2021-02-04 Luca Quaroni , Kingshuk Bandopadhyay , Marzena Mach , Paweł Wydro , Szczepan Zapotoczny

The outstanding lubrication of articular cartilage in the major synovial joints such as hips and knees, essential for the joint well-being, has been attributed to boundary layers of lipids at the outer cartilage surfaces, which have very…

Soft Condensed Matter · Physics 2024-04-10 Di Jin , Jacob Klein

Coulomb interactions are present in a wide variety of all-atom force fields. Spherical truncations of these interactions permit fast simulations but are problematic due to their incorrect thermodynamics. Herein we demonstrate that simple…

Statistical Mechanics · Physics 2015-05-14 Jocelyn M. Rodgers , John D. Weeks

The study of interactions between biomimetic membranes and micron-sized particles is crucial for understanding various biological processes. Here, we control microparticle spontaneous engulfment by giant lipid vesicles by tuning particle…

Soft Condensed Matter · Physics 2025-01-22 Clément Marque , Gaetano D'Avino , Domenico Larobina , Aude Michel , Ali Abou-Hassan , Antonio Stocco

Lipid bilayers often form high-curvature configurations due to self-assembly conditions or certain biological processes. However, particle-based simulations of lipid membranes are predominantly of flat lipid membranes because planar…

Soft Condensed Matter · Physics 2025-01-31 James Tallman , Antonia Statt

We report on atomistic simulations of DPPC lipid monolayers using the CHARMM36 lipid force field and four-point OPC water model. The entire two-phase region where domains of the `liquid-condensed' (LC) phase coexist with domains of the…

Soft Condensed Matter · Physics 2019-03-18 S. Panzuela , D. P. Tieleman , L. Mederos , E. Velasco

Dielectrically confined Coulomb systems are widely employed in molecular dynamics (MD) simulations. Despite extensive efforts in developing efficient and accurate algorithms for these systems, rigorous and accurate error estimates, which…

Numerical Analysis · Mathematics 2025-03-25 Xuanzhao Gao , Qi Zhou , Zecheng Gan , Jiuyang Liang