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We study biological evolution in a high-dimensional genotype space in the regime of rare mutations and strong selection. The population performs an uphill walk which terminates at local fitness maxima. Assigning fitness randomly to…

Populations and Evolution · Quantitative Biology 2015-05-28 Johannes Neidhart , Joachim Krug

Rare evolutionary events, such as the rise to prominence of deleterious mutations, can have drastic impacts on the evolution of growing populations. Heterogeneous environments may reduce the influence of selection on evolutionary outcomes…

Populations and Evolution · Quantitative Biology 2024-10-10 Jimmy Gonzalez Nuñez , Daniel A. Beller

We investigate the evolution of quiescence within the framework of Adaptive Dynamics for an SIQS (Susceptible - Infected - Quiescent) model with constant environment. In the first part of the paper, the competition of two strains which have…

Populations and Evolution · Quantitative Biology 2025-07-14 Leonard Braun , Noah Risse , Aurélien Tellier , Johannes Müller

This paper develops mathematical models describing the evolutionary dynamics of both asexually and sexually reproducing populations of diploid unicellular organisms. We consider two forms of genome organization. In one case, we assume that…

Populations and Evolution · Quantitative Biology 2009-07-17 Maya Kleiman , Emmanuel Tannenbaum

Large sets of genotypes give rise to the same phenotype because phenotypic expression is highly redundant. Accordingly, a population can accept mutations without altering its phenotype, as long as thegenotype mutates into another one on the…

Populations and Evolution · Quantitative Biology 2015-02-18 Susanna Manrubia , José A. Cuesta

We model the robustness against random failure or intentional attack of networks with arbitrary large-scale structure. We construct a block-based model which incorporates --- in a general fashion --- both connectivity and interdependence…

Physics and Society · Physics 2012-09-25 Tiago P. Peixoto , Stefan Bornholdt

Phenotypic evolution implies sequential fixations of new genomic sequences. The speed at which these mutations fixate depends, in part, on the relative fitness (selection coefficient) of the mutant vs. the ancestor. Using a simple…

Populations and Evolution · Quantitative Biology 2014-02-04 Sorin Tanase-Nicola , Ilya Nemenman

Spatial environmental variation can either amplify or suppress the fixation of beneficial mutants in structured populations, yet the interplay of ecological factors and spatial structure in determining which outcome occurs remains…

Populations and Evolution · Quantitative Biology 2026-05-07 Hossein Nemati , Kamran Kaveh , Jakub Svoboda , Mohammad Reza Ejtehadi , Krishnendu Chatterjee

A quasispecies evolving on a fitness landscape with a single peak of fluctuating height is studied. In the approximation that back mutations can be ignored, the rate equations can be solved analytically. It is shown that the error threshold…

Biological Physics · Physics 2007-05-23 Martin Nilsson , Nigel Snoad

Consider an advantageous allele that arises in a haploid population of size $N$ evolving in continuous time according to a skewed reproduction mechanism, which generates under neutrality genealogies lying in the domain of attraction of a…

Probability · Mathematics 2024-09-02 Matthias Birkner , Florin Boenkost , Iulia Dahmer , Cornelia Pokalyuk

Evolution on neutral networks of genotypes has been found in models to concentrate on genotypes with high mutational robustness, to a degree determined by the topology of the network. Here analysis is generalized beyond neutral networks to…

Populations and Evolution · Quantitative Biology 2015-09-01 Lee Altenberg

Weak selection, which means a phenotype is slightly advantageous over another, is an important limiting case in evolutionary biology. Recently it has been introduced into evolutionary game theory. In evolutionary game dynamics, the…

Populations and Evolution · Quantitative Biology 2010-10-15 Bin Wu , Philipp M. Altrock , Long Wang , Arne Traulsen

Exploiting the mathematical curiosity of intransitive dice, we present a simple theoretical model for co-evolution that captures scales ranging from the genome of the individual to the system-wide emergence of species diversity. We study a…

Populations and Evolution · Quantitative Biology 2022-12-02 Julius B. Kirkegaard , Kim Sneppen

We model evolution of plants in a world, made up of different locations, with multiple environments (mutually exclusive and collectively exhaustive subsets of locations). Each environment (landmass) has temperature, rainfall, and other…

Populations and Evolution · Quantitative Biology 2019-05-27 Alexander , Khazatsky , Albert Yu , Zihao Zhao , Gabe Zuckerman

Characterization of the differences between biological and random networks can reveal the design principles that enable the robust realization of crucial biological functions including the establishment of different cell types. Previous…

Molecular Networks · Quantitative Biology 2020-08-26 Shubham Tripathi , David A. Kessler , Herbert Levine

Many life-history traits, like the age at maturity or adult longevity, are important determinants of the generation time. For instance, semelparous species whose adults reproduce once and die have shorter generation times than iteroparous…

Populations and Evolution · Quantitative Biology 2016-04-22 Mélissa Verin , Salomé Bourg , Frédéric Menu , Etienne Rajon

Evolution occurs in populations of reproducing individuals. The structure of a biological population affects which traits evolve. Understanding evolutionary game dynamics in structured populations is difficult. Precise results have been…

Populations and Evolution · Quantitative Biology 2017-08-16 Benjamin Allen , Gabor Lippner , Yu-Ting Chen , Babak Fotouhi , Naghmeh Momeni , Martin A. Nowak , Shing-Tung Yau

In biology and ecology, individuals or communities of individuals living in unpredictable environments often alternate between different evolutionary strategies to spread and reduce risks. Such behavior is commonly referred to as…

Populations and Evolution · Quantitative Biology 2015-03-11 Jorge Hidalgo , Simone Pigolotti , Miguel A. Munoz

We study in detail a recently proposed simple discrete model for evolution on smooth landscapes. An asymptotic solution of this model for long times is constructed. We find that the dynamics of the population are governed by correlation…

Condensed Matter · Physics 2009-10-28 David A. Kessler , Herbert Levine , Douglas Ridgway , Lev Tsimring

Here we provide a detailed analysis, along with some extensions and additonal investigations, of a recently proposed self-organised model for the evolution of complex networks. Vertices of the network are characterised by a fitness variable…

Physics and Society · Physics 2008-08-29 Guido Caldarelli , Andrea Capocci , Diego Garlaschelli